22 replies to this topic

[GregLong]

Hello everyone.

I have been following a regimen of, basically, LEF multi ingredient tablets, plus 250 mg Resveratrol and 2000mg Sodzyme (Glisodin) as a free radical scavenger. I have not seen much about Glisodin on this forum, and am wondering if I am wasting my money. Any thoughts on this product?

[pycnogenol]

I take the Now Foods GliSODin product. I wish I could afford the LEF Sodzyme.

[mitkat]

I take the Now Foods GliSODin product. I wish I could afford the LEF Sodzyme.

Same here on both accounts. I'm not sure if as many members are taking it as once were but I take one of the Now! product everyday, far away from workouts. As for it's true efficacy, I'm not certain. I'm a bit on the fence about continuing to take it as I've been cutting back quite a bit recently on supp spending.

[rwac]

I take the Now Foods GliSODin product. I wish I could afford the LEF Sodzyme.

Same here on both accounts. I'm not sure if as many members are taking it as once were but I take one of the Now! product everyday, far away from workouts. As for it's true efficacy, I'm not certain. I'm a bit on the fence about continuing to take it as I've been cutting back quite a bit recently on supp spending.

Anybody noticed any improvement due to gliSODin ?
Do you take it for a specific purpose, or just as an Anti-Oxidant ?

[pycnogenol]

I take the Now Foods GliSODin product. I wish I could afford the LEF Sodzyme.

Same here on both accounts. I'm not sure if as many members are taking it as once were but I take one of the Now! product everyday, far away from workouts. As for it's true efficacy, I'm not certain. I'm a bit on the fence about continuing to take it as I've been cutting back quite a bit recently on supp spending.

Anybody noticed any improvement due to gliSODin ?
Do you take it for a specific purpose, or just as an Anti-Oxidant ?

I take it to look absolutely ravishing Other than that, I take it for its antioxidant qualities.

Oh, my eyesight seems slightly improved when taking GliSODin but then again I take Bilberry
(Jarrow Formulas brand) so who the heck knows?

[tunt01]

just putting in my 2 cents:

- personal health history/pathology puts me at high risk for ischemia (hypertension/stroke, etc.). i have been checked for celiac by a GI and am negative for the condition.
- i just got the LEF SODzyme yesterday. i'm on my 2nd day of taking the product. I've done the standard 100 mg of glisodin / 3 pills of SODZyme. today I took 2 in the AM upon waking, and 1 in the mid afternoon.
- i have had an ENORMOUS improvement in energy. this product is very good. i may buy the endothelial defense also for AM use and SODZyme for PM use.


i actually was looking around to see if anyone has NOT had a material/major improvement in energy, because it might better indicate to me how screwed up my cardio system is vs. others ( lol ).

did anyone notice ZERO/almost zero benefit from sodzyme/glisodin ?

thx

-pro

Edited by prophets, 14 April 2009 - 09:58 PM.

[Shepard]

I didn't notice anything back when I took it (only went through 2-3 bottles, though).

[Lufega]

I have a copper deficiency which leads to low levels of SOD. It's postulated that all my collagen related problems are actually due to low SOD activity leading to rampant free-radical damage all over my body. I'm waiting for my order of LEF SODzyme with glisodin and I have high hopes this will halt or even reverse many of my health problems. One of these, is an alpha-1-antitrypsin deficiency. The increase in energy you're talking about will certainly be a plus.

[tunt01]

thx for feedback shepard. let me know how it goes for you lufega.

i'm on day 3 of SODzyme. yesterday i had the hardest/longest run i've had in 4-5 years to the point where i woke up with a severely sore left ankle today. my body was performing at such a high level, at some points i was barely breathing harder than i am sitting in a chair in front of my PC. normally, i sweat and breathe very hard just to get a full mile run in. i barely broke a sweat in the first 0.5-0.75 mile of a three mile run.

it has made a remarkable change, though i hope it is not short lived. i'm only doing 100 mg of glisodin and am currently contemplating moving up to 400 mg through endothelial defense.

Edited by prophets, 15 April 2009 - 01:45 PM.

[balance]

SODzyme is the old one, supposedly much less effective than GliSODin. That said, lef's endothelial defense is 50 bucks...

I tried both products several times and noticed nothing, I feel it's a waste of money. You're probably better off boosting the production through other means, like for example curcumin boosting sod levels and so on.

[tunt01]

SODzyme is the old one, supposedly much less effective than GliSODin. That said, lef's endothelial defense is 50 bucks...

I tried both products several times and noticed nothing, I feel it's a waste of money. You're probably better off boosting the production through other means, like for example curcumin boosting sod levels and so on.

thx for your feedback.

i take a curcumin pill in the PM, 500 mg. has been good, but not nearly as effective for me as the SODzyme so far. the SODZyme difference was day and night.

[krillin]

I've noticed no effects from 250 mg/day GliSODin. I take it to prevent mitochondrial free radical damaged cells from exporting misery via superoxide -> oxidized LDL. GliSODin prevents atherosclerosis in humans, so it should do the job.

Eur Ann Allergy Clin Immunol. 2007 Feb;39(2):45-50.
GliSODin, a vegetal sod with gliadin, as preventative agent vs. atherosclerosis, as confirmed with carotid ultrasound-B imaging.
Cloarec M, Caillard P, Provost JC, Dever JM, Elbeze Y, Zamaria N.
Association Nationale de Prevention Médicale, 14, rue de l'Abbé Grégoire, F-75005 Paris.

Prevention of cardiovascular disease should target high-risk subjects based on genetic/familial factors, blood chemistry, blood pressure, body mass index (BMI), and a history of/or current cigarette smoking. We selected active adults (n=76) aged 30-60 and investigated these risk factors, in order to recommend preventive measures. Another interesting variable is the preclinical status or atheroma of the arterial (carotid) wall or lumen. We also investigated the presence of oxidative stress in, and the anti-oxidant status of these subjects. We studied the anti-oxidative efficacy of superoxide dismutase (SOD) and variations of malondialdehyde (MDA). Supplementation with GliSODin, a vegetal SOD associated with gliadin, was effective in controlling the thickness of the carotid artery intima and media layers as measured by ultrasonography-B. We could demonstrate the preventive efficacy of GliSODin at a preclinical stage in subjects with risk factors of cardiovascular disease.

PMID: 17441415

[krillin]

thx for feedback shepard. let me know how it goes for you lufega.

i'm on day 3 of SODzyme. yesterday i had the hardest/longest run i've had in 4-5 years to the point where i woke up with a severely sore left ankle today. my body was performing at such a high level, at some points i was barely breathing harder than i am sitting in a chair in front of my PC. normally, i sweat and breathe very hard just to get a full mile run in. i barely broke a sweat in the first 0.5-0.75 mile of a three mile run.

it has made a remarkable change, though i hope it is not short lived. i'm only doing 100 mg of glisodin and am currently contemplating moving up to 400 mg through endothelial defense.

Have you ever tried coenzyme Q10? Maybe the GliSODin is sparing it, so more is available for the mitochondria. Pomegranate is also good for preventing LDL oxidation. And limit alpha tocopherol, since high doses deplete CoQ10. I get 150 IU/day through diet and contaminated supplements. (50 IU from gamma E, 50 IU from astaxanthin, 30 IU from selenium.) Seems reasonable based on all the references here, but I wouldn't argue against a lower dose.

Clin Nutr. 2004 Jun;23(3):423-33.
Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotid intima-media thickness, blood pressure and LDL oxidation.
Aviram M, Rosenblat M, Gaitini D, Nitecki S, Hoffman A, Dornfeld L, Volkova N, Presser D, Attias J, Liker H, Hayek T.
The Lipid Research Laboratory, Rappaport Family Institute for Research in the Medical Sciences, Rambam Medical Center, Haifa 31096, Israel. aviram@tx.technion.ac.il

Dietary supplementation with polyphenolic antioxidants to animals was shown to be associated with inhibition of LDL oxidation and macrophage foam cell formation, and attenuation of atherosclerosis development. We investigated the effects of pomegranate juice (PJ, which contains potent tannins and anthocyanins) consumption by atherosclerotic patients with carotid artery stenosis (CAS) on the progression of carotid lesions and changes in oxidative stress and blood pressure. Ten patients were supplemented with PJ for 1 year and five of them continued for up to 3 years. Blood samples were collected before treatment and during PJ consumption. In the control group that did not consume PJ, common carotid intima-media thickness (IMT) increased by 9% during 1 year, whereas, PJ consumption resulted in a significant IMT reduction, by up to 30%, after 1 year. The patients' serum paraoxonase 1 (PON 1) activity was increased by 83%, whereas serum LDL basal oxidative state and LDL susceptibility to copper ion-induced oxidation were both significantly reduced, by 90% and 59%, respectively, after 12 months of PJ consumption, compared to values obtained before PJ consumption. Furthermore, serum levels of antibodies against oxidized LDL were decreased by 19%, and in parallel serum total antioxidant status (TAS) was increased by 130% after 1 year of PJ consumption. Systolic blood pressure was reduced after 1 year of PJ consumption by 12% [corrected] and was not further reduced along 3 years of PJ consumption. For all studied parameters, the maximal effects were observed after 1 year of PJ consumption. Further consumption of PJ, for up to 3 years, had no additional beneficial effects on IMT and serum PON1 activity, whereas serum lipid peroxidation was further reduced by up to 16% after 3 years of PJ consumption. The results of the present study thus suggest that PJ consumption by patients with CAS decreases carotid IMT and systolic blood pressure and these effects could be related to the potent antioxidant characteristics of PJ polyphenols.

PMID: 15158307

[tunt01]

thanks for your input krillin.

- I have been taking ubiquinone / CoQ10 for a while now. I tend to take 100 mg, 2-3x per day sublingually before I go run or throughout the day inbetween meals. It tends to be slightly helpful and my body is sensitive enough that I can typically feel a mild effect.

- i don't directly supplement Vitamin E and don't really know my exact in take. i eat a very healthy diet of vegetables, nuts, etc. so i figure i probably get enough.

- i have looked at astaxanthin and thought about supplementing with it. it was on my list of things to try, i just have not gotten to it yet.

- i do drink pomegranate juice now and then. im thinking of just using the endothelial defense for that reason.

the effect sodzyme (glisodin) has for me has still been distinctly remarkable and very significant. im going to wait til i've used this stuff for a few weeks before coming to any final conclusions. but the immediate impact is on the magnitude of 'life changing' - sort of like the feeling between being afflicted with fibromyalgia to feeling normal in the span of a day or two. and i say this as a person who is typically very reserved, pessimistic, and careful in their thought.

- i actually wish there was a time release version of glisodin.
- i think i need to start supplementing with zinc/copper and maybe manganese to prevent any rate limiting on Cu/ZnSOD or MnSOD.
- i wish there were more studies on overdose risk and the LT effects of supplementing with something so powerful.

Edited by prophets, 16 April 2009 - 12:51 PM.

[tunt01]

before i do more research:

does anyone know if there are serious LT health primary issues related to excess SOD/glisodin?

I'm thinking like cancer or some kind of build-up of a bi-product which SOD is breaking down?

how does one think about the positive effects of superoxide in preventing other deleterious health conditions in the body? ie. what if a person has a lot of free radicals as a result of a virus, does SOD supplementation through glisodin then become another type of risk?

thx

Edited by prophets, 16 April 2009 - 02:54 PM.

[krillin]

- I have been taking ubiquinone / CoQ10 for a while now. I tend to take 100 mg, 2-3x per day sublingually before I go run or throughout the day inbetween meals. It tends to be slightly helpful and my body is sensitive enough that I can typically feel a mild effect.

the effect sodzyme (glisodin) has for me has still been distinctly remarkable and very significant. im going to wait til i've used this stuff for a few weeks before coming to any final conclusions. but the immediate impact is on the magnitude of 'life changing' - sort of like the feeling between being afflicted with fibromyalgia to feeling normal in the span of a day or two. and i say this as a person who is typically very reserved, pessimistic, and careful in their thought.

That's an unusual CoQ10 protocol. I thought it was best to take with fat in divided doses. (To avoid diminishing returns, not to smooth out peaks and valleys. Its half-life is large.) Is sublingual that much better?

Since GliSODin works so much better for you than CoQ10, I think I'll go with Martin Pall's theory (p. 62) that superoxide and peroxynitrite (combination of superoxide and NO) deactivate things in the mitochondria.

[tunt01]

That's an unusual CoQ10 protocol. I thought it was best to take with fat in divided doses. (To avoid diminishing returns, not to smooth out peaks and valleys. Its half-life is large.) Is sublingual that much better?

Since GliSODin works so much better for you than CoQ10, I think I'll go with Martin Pall's theory (p. 62) that superoxide and peroxynitrite (combination of superoxide and NO) deactivate things in the mitochondria.

sorry, i mis-wrote that. outside of the period where i get ready to run, i take the coq10 with nuts, dark chocolate, or yogurt

thx the link. i think it has to do w/ having impaired anti-oxidant levels. i think it is superoxide.

the thing about glisodin is that i feel like i have to surrender my CNS/Immune response to the product when I take it. it is like being sedated almost. i may try other ways of upping my endogenous SOD w/o taking the glisodin.

Edited by prophets, 17 April 2009 - 01:34 PM.

[nameless]

And limit alpha tocopherol, since high doses deplete CoQ10. I get 150 IU/day through diet and contaminated supplements. (50 IU from gamma E, 50 IU from astaxanthin, 30 IU from selenium.) Seems reasonable based on all the references here, but I wouldn't argue against a lower dose.

At what dosage would alpha tocopherol begin seriously depleting CoQ10, or even gamma tocopherol?

I don't supplement with Es specifically, besides what's in my AOR multi (partial dose) but I do get extra alpha from my fish oil. I thought I read the data supported alpha up to around the 50IU or so mark, and higher values then began to show increased overall mortality. But I'm not certain if this was due to gamma depletion or some other thing going on there.

And any concern over the gliadin in Glisodin? Or is it only a tiny amount that is inconsequential?

http://www.imminst.o...o...&hl=sodzyme

[Lufega]

I've also taken coQ10 with no noticeable benefits. I've only had one dose of glisodin but I felt remarkable.

Prophets,

Check your mineral status carefully before you add copper/zinc/manganese. You can do harm with too much of any of these. I think I gave myself another hernia using copper, even though I'm deficient. Storage problem???

[tunt01]

Check your mineral status carefully before you add copper/zinc/manganese. You can do harm with too much of any of these. I think I gave myself another hernia using copper, even though I'm deficient. Storage problem???

I am going to look into this, I think it is a good point. I've seen your mineral evaluation links from the other thread and will evaluate it.

I have taken no Glisodin today, but did take a regular dosing of curcumin/lipoic acid/other antioxidants which upregulate SOD, etc. I wanted to see what a day off of the stuff would feel like; I have been pretty calm, but maybe a bit less focused/productive today. I may only end up taking Glisodin intermittently, when I am most stressed.

I'm going to poke around and look at endogenous SOD/GPx production a bit more. I'm not a triathlete, but it seems like their physiology is the ideal long-term. This one exerpt was interesting.

Oxidative stress in half and full Ironman triathletes.

INTRODUCTION: Ultraendurance athletes who maintain a very high volume of exercise may, as a result of greater production of reactive oxygen species (ROS), be particularly susceptible to oxidative damage. PURPOSE: This study sought to examine and compare pre- and postrace markers of oxidative stress in ultraendurance athletes training for, and competing in, either a half or a full Ironman triathlon. METHODS: Resting and postexercise blood was sampled from 16 half Ironman triathletes, 29 full Ironman triathletes, and age-matched, relatively inactive controls. Blood was analyzed for markers of oxidative stress (malondialdehyde (MDA) concentration) and antioxidant status (glutathione peroxidase (GPX), catalase (CAT), and superoxide dismutase (SOD) activities). RESULTS: Compared with controls, the half Ironman triathletes had significantly (P < 0.001) higher erythrocyte GPX activity at rest, whereas the Ironman triathletes had significantly (P < 0.05) lower resting plasma MDA and significantly (P < 0.05) greater resting activities of GPX and CAT compared with controls. As a result of the half Ironman triathlon, there was a significant (P < 0.05) increase in MDA and significant (P < 0.05) decreases in erythrocyte GPX, SOD, and CAT activities. These changes also occurred in response to the Ironman triathlon; MDA significantly (P < 0.05) increased, and there were significant (P < 0.001) decreases in GPX, CAT, and SOD activities. Users of antioxidant supplements in both the half and full Ironman races had significantly (P < 0.05) elevated MDA after races compared with nonsupplementers. CONCLUSION: The present investigation indicates that training for and competing in half and full Ironman triathlons has different effects on erythrocyte antioxidant enzyme activities and oxidative stress.

[RGK]

For technical specs re Sodzyme see http://en.wikipedia.com/SOD/CAT . Using SodZyme and LEF Resveratrol covers a lot of positive molecular signaling pathways. Maybe Lef with blend a product with those two ingredients. Of course, one can always just go on a calorie restricted diet for twenty or thirty years too.

-RGK

[Lufega]

I've been using Glisodin now for 3 months. One thing that is immediately apparent is increased muscle mass. Whatever it is I have, never allowed my body to develop a normal and healthy musculature, even when I would work out. Now, at 30, my body is finally taking toned form and I'm retaining that mass. Now I know that whatever it was, it involved high levels of oxidative stress.

Also, my CK levels were always high, signaling constant muscle breakdown. I need to recheck them.

Edited by Lufega, 06 August 2009 - 12:54 AM.

[biochemie]

I've been using Glisodin now for 3 months. One thing that is immediately apparent is increased muscle mass. Whatever it is I have, never allowed my body to develop a normal and healthy musculature, even when I would work out. Now, at 30, my body is finally taking toned form and I'm retaining that mass. Now I know that whatever it was, it involved high levels of oxidative stress.

Also, my CK levels were always high, signaling constant muscle breakdown. I need to recheck them.

I would probably guess overtraining. Aka, not allowing enough rest in between your workouts for optimal growth and recuperation. Hint: Check out the Mike Mentzer books.