one of the things that gives away pretty much what diet humans have evolved/adapted to is when you examine hypothalamic appetite regulation (the brain's appetite control centers receive information from afferents and hormones in response to food from the mouth to the small intestine). protein and fat (chains >12) have a high satiety index with protein having the longest satiety effect. on the other hand, fructose does the opposite in the brain because it causes an ATP drop (during conversion to glucose) which is perceived as a shortage of food. unsuprisingly fruit has a low satiety index. also, unlike glucose which can be directly absorbed in muscle, fructose has to be converted in the liver to glucose before it can be used. in addition to the metabolism destabilizing effects of glucose, it has also been shown to be addictive.
from an appetite regulation perspective, the paleo/duke diet is most in line with how the brain has evolved to sense nutrients
I disagree. A fructose low-satiety response makes perfect sense if you consider that, when an early human came upon a tree bearing ripe fruit, he could either gorge himself or lose out to the monkeys, birds, and rot. In this context, gorging was a good thing.