Yep, I might. Although I thought the data on chondroitin wasn't so promising?
I'm pretty sure chondroitin has been proven to do nothing on its own. However, it may be synergistic with glucosamine/MSM. I don't know.
And which form of glucosamine is considered best? I'm a little hesitant with glucosamine, due to potential insulin or glucose issues, but I think that occurred only in the ratty studies.
No, it's not as clear cut as you might think. I've checked the literature once after reading Andre's concerns in his regimen thread and I've found both positive and negative results.
At least anecdotally I can say that glucosamine
may have some influence on glucose metabolism. I've been using glucosamine for years and had 2 fasting glucose readings at 100mg/dl in a row, I dropped the glucosamine this winter (but started taking ~1200IU vitamin D at the same time while unfortunately the two other readings were done in winter and spring) then took another test which came in at 86mg/dl. Now i'm somewhat perplexed, as I've always tried to improve my fasting glucose and I'm not sure what did the trick (I'm pretty sure the labs use the same reference ranges, but I'll check that again tomorrow). How big is inter-, intra-lab and intra-person variation when it comes to fasting glucose testing? (maybe they're completely worthless?)
My understanding of glucose metabolism is not good enough to arrive at a conclusion in any case, but you can take a look at some studies (haven't read more than their abstracts):
It does1500mg, n = 38, 6 weeks; HOMA-IR and small artery elasticity worsened in those with
underlying poorer insulin resistance.
Am J Med Sci. 2007 Jun;333(6):333-9. Oral glucosamine in doses used to treat osteoarthritis worsens insulin resistance. Pham T, Cornea A, Blick KE, Jenkins A, Scofield RH. Endocrinology Division, Department of Medicine, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma, USA.
n=10
"Infusion of GlcN did not affect readily releasable insulin levels, glucose-stimulated insulin secretion (GSIS), or the time constant of secretion, but it increased both the glucose threshold of GSIS ... and plasma fasting glucose levels"Diabetes. 2000 Jun;49(6):926-35.
Effects of glucosamine infusion on insulin secretion and insulin action in humans.
Monauni T, Zenti MG, Cretti A, Daniels MC, Targher G, Caruso B, Caputo M, McClain D, Del Prato S, Giaccari A, Muggeo M, Bonora E, Bonadonna RC.
http://diabetes.diab...eprint/49/6/926It doesn't1,500 mg/day for 6 weeks, n=40
Diabetes. 2006 Nov;55(11):3142-50.
Oral glucosamine for 6 weeks at standard doses does not cause or worsen insulin resistance or endothelial dysfunction in lean or obese subjects.
Osteoarthritis Cartilage. 2004 Jun;12(6):506-11.
Effect of glucosamine supplementation on fasting and non-fasting plasma glucose and serum insulin concentrations in healthy individuals.
J Clin Endocrinol Metab. 2001 May;86(5):2099-103.
Short-term glucosamine infusion does not affect insulin sensitivity in humans.
Pouwels MJ, Jacobs JR, Span PN, Lutterman JA, Smits P, Tack CJ.
Edited by kismet, 06 April 2009 - 11:17 PM.