10 replies to this topic

[kevin]

As we've seen in some fairly recent press releases, resveratrol has been shown to have the ability to stimulate gene expression in a similar manner to that of caloric restriction through the sirtuin pathway. One of the leading scientists and main publisher's of resveratrols effects, David Sinclair, is selling what he calls a 'biologically active' form of resveratrol in the product Longevinex. From what I've read about resveratrol it looks like its antiaging claims have some validity but it remains to be seen 'how' valid they are in humans and antiaging.

check out http://www.longevinex.com to see how nice a slick a package he has put together for marketing the product. (I've ordered two bottles.. heh.. )

[kevin]

I have just found this message on sci.life-extension.. from David Sinclair.. it seems he's not too happy about his name being used to promote the product. Here's a link to the Longevinex's promotion using his name..

http://www.longevinex.com/hlshl.htm
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and his response..
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Today's Topics:

1. Longevinex - Sinclair response (David Sinclair)

--__--__--

Message: 1
Date: Mon, 29 Dec 2003 14:54:43 -0500
From: David Sinclair
To:
Subject: [SAGEMAIL] Longevinex - Sinclair response
Reply-To: sagemail@aaas.org

> This message is in MIME format. Since your mail reader does not understand
this format, some or all of this message may not be legible.

--B_3155554484_10945005
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Happy Holidays Everyone,

A company selling a product called "Longevinex" has been using my name to
promote their product. As a result, my consulting agreement with this
company was terminated. I never received any money from this company and I
have taken steps to ensure that they do not use my name to promote products
in the future.

Best regards,

David Sinclair
(617)432 3931

[hughbristic]

Here is some more from sci.life-extension on this issue.

Hugh

Manfred Bartz writes:

> cracraft@cox.net (Stuart Cracraft) writes:
>
>> Anyone know any company making a LiCaps-style
>> (sealed capsule) with Resveratrol in suspension?
>> Resveratrol oxidizes quickly and so something
>> like this is needed.
>
> So they claim.

This discussion thread has drawn some attention at Longevinex
(www.longevinex.com), and I received the following reply from
Longevinex / Bill Sardi [email address removed]:

------------------------------------------------------------

I'm viewing your discussion on a sciencegroup.com regarding
resveratrol supplements.

I visited Dr. Sinclair's lab, wrote an article about his work (soon
to be published in Functional Foods & Nutraceuticals magazine) and
was urged to help develop a biologically active resveratrol pill
when Dr. Sinclair at Harvard Med School showed that none of the
current dietary supplements exhibit any significant biological
activity. Some don't even have any resveratrol at all. Dr. Leroy
Creasy of Corneal reported some time back that dietary supplements
do not provide a significant amount of resveratrol. If you search
long enough you will find research-grade resveratrol is available at
about $5.00 per milligram. The suppliers note their 100%
research-grade product is produced under nitrogen and sealed in
airtight packages. Wine from red grapes utilizes fermentation to
extract the resveratrol from the grape skin and then the airtight
bottle preserves it. There is not one study showing a resveratrol
pill is biologically active, but there are plenty of studies showing
bottled red wine exhibits unusual health benefits. The Longevinex
product was developed to duplicate the same process and environment
involved in making red wine. The airtight LICAPS capsule is
produced by Capsugel under exclusive license (confirmed in writing
from Capsugel attorneys) for Longevinex. You can view the Capsugel
website to learn about their patented process (worldwide patent).
Even softgel capsules cannot duplicate LICAPS since raw material is
exposed to oxygen and heat prior to encapsulation. Capsugel
processes their product solely in a nitrogen environment.
Furthermore, proprietary stabilizers are added to the Longevinex
formula (patent pending) to maintain stability within the capsule
itself. There is a nitrogen air bubble inside the Licaps pills.

The availability of the Longevinex capsule has been delayed. The
product has been produced and packaged in a foil seal pack, but
boxes are late in being printed. Longevinex should be available for
shipping within days. I recognize the skepticism in your emails,
but all I can say is that the Longevinex product is one-of-a-kind
and lives up to its claims. It provides the world's first
biologically stable resveratrol, preserved in an airtight capsule.
Unfortunately the other suppliers of resveratrol supplements have no
idea the raw material needs to be preserved in some manner. Under
HPLC the resveratrol molecule is there when they put it in the
gelatin caps of these other products. The manufacturers cannot
fathom that it disappears soon thereafter. This is all new to them.
There are other natural molecules that are similar. I've also
written a book all about resveratrol as an anti-aging pill, and it
has been sent to the printer and should be available soon. My
initial involvement with resveratrol was as a writer, but I've been
coaxed into heading up the company providing Longevinex, and I now
properly indicate this in my articles, that I have a commercial
interest in the product. I hope the Longevinex product will gain
your confidence.

------------------------------------------------------------

I have been extremely skeptical about the claims made by Longevinex
(www.longevinex.com). Without conclusive evidence for the efficacy
and/or necessity of the special packaging method I am still inclined
to adopt a wait and see approach. Publication of independent lab
analysis data which demonstrates the efficacy of the supplement at a
time when the consumer is likely to ingest it would change that.

--
Manfred Bartz

[Bruce Klein]

excellent info.

[Da55id]

I am very serious when I say that I would like to see vendors who make life extension claims/implications enter the Methuselah Mouse competition. There is no charge to enter, and the science board is world class.

I for one am tired of buying pills wherein I have no earthly idea if anything really works.

I also have to believe that a manufacturer that has the supreme confidence in their product that they evince on their websites would welcome the opportunity to win what is a growing and now significant prize fund. Thus, the competition would serve all as an "Underwriter's Lab".

All we need is for folks here to tell such MFGRs that they want the company to enter the competition. Imagine the marketing benefits that would accrue to a company that WON!

What do you think BJ?

[hughbristic]

Looks like longevinex is shipping now. They just tried to charge my account with my debit card and it was declined so they called to let me know they were shipping and to get a new card number.

[Bruce Klein]

What do you think BJ?

Sorry just saw this question. I concur with your assessment, Dave. I'll keep this in mind as it's mainly knowing who and how to ask. The more we can effectively network the better.. you know the drill.

[nosmadar]

I received this product last week and it does seem to be having some effect. This may be incidental but, I took a capsule before I went to sleep (I usually take metformin and melatonin) along with C-ester and E and a multiple B complex. Also about an hour or less earlier, I had eaten some cashews so my stomach was not empty. Early on into sleep I started experiencing huge surges of growth hormone release. I'm sure you are all aware that in order to have growth hormone release your glucose levels must be sufficiently low. I think there really is something to this product.

[kevin]

nosmadar:

How the heck could you tell that you were experiencing 'surges in growth hormone'?... or maybe I don't want to know.

[nosmadar]

Kevin: Signs that growth hormone is being released during sleep are, brief nasal congestion and increased heart rate.

[kevin]

thanks nosmadar.. I have some on order myself and I'm looking forward to seeing how it feels.. I'll be on the lookout for the above..