Deprenyl [Selegiline HCl] is a irreversible selective MAO-B inhibitor (as I'm sure you all know ) so it is pretty safe to mix with other drug. Obviously not all - in fact, some can have really, really bad reactions - but quite a few prescription medications are okay to take with it. Do you research, though, regarding dosage.
N.B. Irreversible does not mean that that the MAO-B inhibitory effects are permanent; rather that they may persist for up to 1-2 weeks following the last administration. It also means that Selegiline has a cumulative effect: whereas 5mg a day will still only "essentially" have selective MAO-B inhibitory effects, if taken daily for an extended period of time it will create a cumulative effect where the inhibition remains and so you are actually 'topping up' your dose, eventually leading to normal MAOI issues. Hence why, if you are taking Deprenyl as a Nootropic for motivation/concentration etc, as an anti-aging compound or as a supplement, it is recommended that you either take it EOD (Every Other Day) or 2-3 time a week, or taper your dose DOWN as you progress...
At low-doses, MAO-B inhibition has no (little?) serontonergic effects, which means that - in doses of about 5-10mg - is does no interfere with SSRI's or SNRI's. There may be a small amount of potentiation but nothing too big of a problem so long as you are careful (subjective report). Bear in mind that other drugs and supplements act as mild SSRI's, SNRI's (Tramadol is a fast-acting, short-lived SNRI - not something you'd expect), DARI's, NRI's, NDRI'S and MAOI's so make sure you do a quick browse before you go mixing - even with the herbal supplements. Off the top of my head I can think of some herbals that have these properties:
Cats Claw - lots of alkaloids that possess non-selective MAO-B inhibition
Kava Kava - a few MAO-B inhibiting alkaloids
Ayahuasca - MAOI
Kanna - SSRI properties
St. Johns Wort - strong MAOI
Liquorice Root - ^^ same as above
Yohimbe - weak MAOI
Passion Flower - small amounts of MAOI and SSRI alkaloids in some cases
Rhodiola Rosea - not direct an MAO-x if I remember correctly, but has something to do with 'balancing' MAO-x's. Would advise being looking this one up.
*** I may well be wrong about the above; I haven't cross-checked, I'm just remembering things I've seen written before. However, my point is that you need to be careful, BUT - due to Selegiline's specificity - if you are careful with how much, when and with what you take it with then you shouldn't run into any major problems. I've read of people taking 250mg Tramadol with 10mg Deprenyl; I've read of people taking 5mg Ritalin and 2.5mg Deprenyl; I've read of people taking small doses of PEA and Selegiline on a daily basis and, whilst probably not that good for you if done repeatedly, they were fine. I believe there is even a member on this forum whose takes 100-200mg Tramadol + 10mg Deprenyl + DLPA and even sometimes 5mg Adderall daily. You'd have to have quite a tolerance to deal with that, but it is an example that it's possible. It's only that though: an example, not a green light to push the boundaries. Probably the most dangerous issue with Selegiline and other drugs is hypertensive crisis. Hypertensive crisis IS a major issue, and you'll want to get yourself to a hospital immediately if you do something stupid and notice skin flushing and migraine-esque headaches, but no one here is that stupid...right? Numerous SSRI's plus high-doses of Selegiline also bear the risk of Serotonin Syndrome, but it's a lot harder to get than Wikipedia implies... ***
/completely unrelated information on Selegiline
________________________________________________________________________________
__________________
Annnyyywwwaaayy, more to the point:
I was just wondering at what point Selegiline becomes goes from a selective MAO-B inhibitor to a non-selective MAO-A inhibitor in these cases:
1) Dosage alone. 5-10mg is considered to only have MAO-B inhibitory effects, whereas...30mg (for example) would cause MAO-A inhibition. But where is the line? Assuming it is one's first time taking Selegiline, what dose would trigger its MAO-B effects, and what dose would trigger its MAO-A [more dangerous]?
2) How long does it take for the cumulative use of daily Selegiline to cross over into MAO-A territory? Using this example: 5mg a day, with food, everyday --> how long until you are getting MAO-A inhibitory effect?
I ask this because, in a previous thread, I got lots of helpful feedback from users (thanks again to those who gave me input ) basically saying how my Nootropic stack was fine with Deprenyl, but I would need to watch out when it came to taking dopamine precursors or pro-drugs, such as L-Tyrosine, NALT, L-DOPA, DL-Phenylalanine and PEA alongside it, as this could seriously overload my CNS with Dopamine, have massive toxic effect and possibly kill me. Sound advice That being said, L-Tyrosine/NALT can be supplemented with Deprenyl in small doses quite effectively, but ONLY once I've got to know how I personally interact with Selegiline.
I've also seen logs for PEA + Selegiline having outstanding results on productivity and mental coherence, but - again - this is only for the experienced and becomes more a more recreational "high" on which one can do lots of work rather than a neuroprotecting-neuroenhancing stack.
Hmm, okay, this turned out more as a rambling statement than a question, but the bit in bold labeled (1) and (2) is what I am interested in. I have just started to factor in Deprenyl to my stack (at a dose of 2.5mg) and I want to make sure I'm being as safe as possible, whilst getting the most out of it.
I know a lot of people here think it's a load of crap and there are other, way more effective Nootropics out there, but I've tried quite a lot and this is one that I'm yet to try and (if it works) sounds right up my alley. So please, no replies like, "Deprenyl is shit. Here's what I take - xxxx - you should do the same." because that's not what I'm after (although if you have any constructive advice/criticisms then that is most welcome
I also have several other thread concerning Selegiline which all kind of tie in with this. I've just created one to do with chewing coca leaf (not cocaine) and Deprenyl, and a few others...
Thanks in advance