18 replies to this topic

[sUper GeNius]

I did some searching, and it seems that Benfotiamine might not be as useful for preventing AGE's in the brain. It was said that the allithiamines, sulbutiamine and fursultiamine, would be better in that regard. I'm a little leery of using sulbutiamine or fursultiamine. Would plain old thiamine be a decent substitute, say 50mg daily?

[rwac]

I did some searching, and it seems that Benfotiamine might not be as useful for preventing AGE's in the brain. It was said that the allithiamines, sulbutiamine and fursultiamine, would be better in that regard. I'm a little leery of using sulbutiamine or fursultiamine. Would plain old thiamine be a decent substitute, say 50mg daily?

I would say thiamine is not absorbed as easily, TTFD (aka fursultiamine aka allithiamine) is much more active.

Sulbutiamine is the nootropic which causes negative side effects.
TTFD actually works pretty well.

You'll need larger doses of thiamine if you want the same effect.
Plus, I believe thiamine doesn't work if you have a transketolase deficiency.

[Lufega]

You wont absorb thiamin is you have a magnesium deficiency, which is very prevalent.

[VampIyer]

Sulbutiamine is the nootropic which causes negative side effects.

Is that based on anecdotal or clinical evidence?

What types of side-effects are you talking about?

[rwac]

Completely anecdotal. Plus it doesn't work for some people.

http://www.imminst.o...showtopic=20040

http://www.imminst.o...showtopic=24656

Edited by rwac, 19 May 2009 - 03:45 AM.

[rwac]

You wont absorb thiamin is you have a magnesium deficiency, which is very prevalent.

Lufega, do you know if TTFD works for Anti-Glycation as well as Thiamine ?

[4eva]

I read somewhere that if you take anymore than 100 mg of thiamine the excess over 100 mg won't be absorbed. I don't know if that is true. But there may be a limitation to how much total thiamine gets absorbed. That's why benfotiamine is a good adjunct.

[rwac]

I read somewhere that if you take anymore than 100 mg of thiamine the excess over 100 mg won't be absorbed. I don't know if that is true. But there may be a limitation to how much total thiamine gets absorbed. That's why benfotiamine is a good adjunct.

These guys talk about thiamine reversing early stage kidney disease with 300 mg Thiamine.
http://www2.warwick....tamin_b1_could/

[Lufega]

You wont absorb thiamin is you have a magnesium deficiency, which is very prevalent.

Lufega, do you know if TTFD works for Anti-Glycation as well as Thiamine ?

I haven't read any studies showing or suggesting it. But if thiamin and benfo. can.....why not?

[sUper GeNius]

I have a question about dosages. If I my aim is to take at least 75 mg of Befotiamine and 75 mg thiamine, plus 50 mg pyridoxamine daily, what sort of balancing act (dosage) should I perform between these and the other B vitamins, like B2 and B5?

[kismet]

I have a question about dosages. If I my aim is to take at least 75 mg of Befotiamine and 75 mg thiamine, plus 50 mg pyridoxamine daily, what sort of balancing act (dosage) should I perform between these and the other B vitamins, like B2 and B5?

None. The B vitamins are completely unrelated (ok, they're all water soluble - but that's all). I just don't know if such low doses will do anything. Any studies?

[sUper GeNius]

I have a question about dosages. If I my aim is to take at least 75 mg of Befotiamine and 75 mg thiamine, plus 50 mg pyridoxamine daily, what sort of balancing act (dosage) should I perform between these and the other B vitamins, like B2 and B5?

None. The B vitamins are completely unrelated (ok, they're all water soluble - but that's all). I just don't know if such low doses will do anything. Any studies?

Why do I always hear that B vitamins need to be taken is some proportion? As far as the dosages, my goal is to be conservative with most of these supplements. What would be considered a conservative dose for these that would have some efficacy in preventing AGE formation?

[kismet]

Why do I always hear that B vitamins need to be taken is some proportion?

It's the internet after all. I have not seen any evidence suggesting this may be true yet.

I'm wondering about dose myself. Typical benfo doses are 200-400mg I think. (the studies in Diabetics generally use 300-600mg) If we assume that higher doses lead to "diminishing returns" 150mg may be of some value..

[sUper GeNius]

Why do I always hear that B vitamins need to be taken is some proportion?

It's the internet after all. I have not seen any evidence suggesting this may be true yet.

I'm wondering about dose myself. Typical benfo doses are 200-400mg I think. (the studies in Diabetics generally use 300-600mg) If we assume that higher doses lead to "diminishing returns" 150mg may be of some value..

Does anyone have a link to Michael Rae's regimen? I think that his would be a good baseline for a conservative regimen, since he's counting on CR and has a "do no harm" philosophy.

[tunt01]

Does anyone have a link to Michael Rae's regimen? I think that his would be a good baseline for a conservative regimen, since he's counting on CR and has a "do no harm" philosophy.

i was searching for this myself the other day, but could not locate it. i'd also appreciate someone else linking this..

[kismet]

Not that it is of any value considering how outdated it is. I suppose Arginine has fallen from grace, from his recent posts I'd say MR probably dropped benfo and added 2000IU vitamin D. But it's always interesting to see how you can get burnt no matter how conservative and minimalistic your regimen is. 

[sUper GeNius]

Not that it is of any value considering how outdated it is. I suppose Arginine has fallen from grace, from his recent posts I'd say MR probably dropped benfo and added 2000IU vitamin D. But it's always interesting to see how you can get burnt no matter how conservative and minimalistic your regimen is. 

That's a quite a feat, dropping in the Ortho Eyes and brushing one's teeth at the same time. Anyway, it doesn't seem that he takes additional B vitamins simply because of his benfotiamine.

I do now recall that he stopped taking it now though, cancer fear right? Anyone know how he handles the AGE issue now? Anyone share his feelings about benfotiamine?

[normalizing]

"Thiamine derivatives with improved pharmacokinetics may prove effective in alleviating the symptoms of thiamine deficiency and other thiamine-related conditions such as impaired glucose metabolism in diabetes. These compounds include allithiamine, prosultiamine, fursultiamine, benfotiamine, and sulbutiamine, among others"

 

some help here, i cannot find any other form except the basic cheap thiamine and the benfotiamine format, how the hell does anyone get the other better studied and made in Japan types which from what i have seen have many years of safe use!

[ironfistx]

why leery of sulbutiamine?