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Resveratrol prevents the expression of glaucoma markers

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#1 maxwatt

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Posted 11 June 2009 - 02:17 AM

This seems to be an in vitro study, but it seems to be very promising: another potential treatment. Not having the full article, I cannot say what concentration of resveratrol was used in the study. It also reduced the expression of lipofuscin.

Food Chem Toxicol. 2009 Jan;47(1):198-204. Epub 2008 Nov 6.
Resveratrol prevents the expression of glaucoma markers induced by chronic oxidative stress in trabecular meshwork cells.

Luna C, Li G, Liton PB, Qiu J, Epstein DL, Challa P, Gonzalez P.
Duke Eye Center, Duke University Medical Center, Box 3802, Durham, NC 27710, USA.

Elevated intraocular pressure (IOP) constitutes the best characterized risk for primary open-angle glaucoma (POAG). Elevated IOP is believed to result from an increase in aqueous humor outflow resistance at the level of the trabecular meshwork ™/Schlemm's canal. Malfunction of the TM in POAG is associated with the expression of markers for inflammation, cellular senescence, oxidative damage, and decreased cellularity. Current POAG treatments rely on lowering IOP, but there is no therapeutic approach available to delay the loss of function of the TM in POAG patients. We evaluated the effects of chronic administration of the dietary supplement resveratrol on the expression of markers for inflammation, oxidative damage, and cellular senescence in primary TM cells subjected to chronic oxidative stress (40% O2). Resveratrol treatment effectively prevented increased production of intracellular reactive oxygen species (iROS) and inflammatory markers (IL1alpha, IL6, IL8, and ELAM-1), and reduced expression of the senescence markers sa-beta-gal, lipofuscin, and accumulation of carbonylated proteins. Furthermore, resveratrol exerted antiapoptotic effects that were not associated with a decrease in cell proliferation. These results suggest that resveratrol could potentially have a role in preventing the TM tissue abnormalities observed in POAG.
PMID: 19027816

#2 albedo

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Posted 20 December 2015 - 04:08 PM

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I wonder if the following review by Dr Sinclair et al. (not read) has something to say in vivo for glaucoma:


Therapeutic potential of resveratrol: the in vivo evidence.


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