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Entheogens-New Category for Nootropic Substances?


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#1 yowza

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Posted 11 June 2009 - 06:44 AM


I've searched around and noticed that nobody has really delved into some of the entheogenic substances found out there. I'm wondering how many people have heard of some of these?

It seems many entheogenic substances are either useless (your traditional herbal supplement that doesn't have a very noticeable psychoactive effect) or appeal to recreational drug users (please leave the hallucinatory substances or entactogens like ecstasy off this thread please since those aren't nootropics since you wouldn't want to take these on a regular basis; especially ecstasy, which would fry your brain if taken more than a couple times a year at lower amounts or 1 time at a high amount). However, there are a number of entheogenic substances that seem to have a pretty big nootropic value.

Feel free to add any additional suggestions or insight entheogens that can heighten affect, attention, or other cognitive processes this would qualify it as a nootropic as long as it's not excessively damaging or something you couldn't take daily. I'll name a few below.

Interesting Entheogens:
Mesembrine (http://www.sceletium.com/):
Some popular entheogenic substances include Mesembrine (khanna; sceletium tortuosum seems to be another name for khanna?; either way this is where mesembrine is extracted from), which is a PDE4 inhibitor known for improving memory. Some also claim it has SRRI type qualities behind it. This is the only herbal psychoactive substance that I have really looked into so far... Has anyone had any experience with this?

Lobeline (this is actually undergoing clinical trials for addictive disorders and adhd thru http://www.yauponthe...m/products.html):
Another Entheogenic substance that sounds interesting is Lobeline (a nicotinic agonist at ganglion receptors and sensory nerve receptors). It seems to bind to the VMA2 (transporter ligand within a nerve cell for dopamine) as well as be antagonistic towards certain nicotine receptors a4b2. This is unfortunate since this area besides nicotinic receptor 7 are areas of the nicotine receptor commonly known for cognition enhancing; however, buproprion is also antagonistic towards a4b2 but still stimulating since it works thru dopamine reuptake inhibition (which is why buproprion as well as lobeline are both used for smoking cessation). However, I for one think nicotine induced stimulation feels alot less rough than direct dopamine stimulation so I'm kind of iffy on the nootropic value of lobeline. Any experiences with this are welcome.

Here's one site that lists some more entheogens:
http://psychoactiveh...c4a3603e82f1257
http://www.ktbotanic...ade-p-6930.html

Edited by yowza, 11 June 2009 - 07:08 AM.

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#2 Guacamolium

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Posted 15 June 2009 - 09:08 PM

Honestly, I think Pfizer - being the largest pharmaceutical giant, should be trying to get an efficacious, safe, pharmaceutical entheogen out there for psychiatry sessions. That would create a new market and possibly help the field of psychotherapy. A new drug class of oxitocinergics could be formed.

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#3 yowza

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Posted 16 June 2009 - 12:56 AM

Honestly, I think Pfizer - being the largest pharmaceutical giant, should be trying to get an efficacious, safe, pharmaceutical entheogen out there for psychiatry sessions. That would create a new market and possibly help the field of psychotherapy. A new drug class of oxitocinergics could be formed.


Interesting idea. I'm thinking there are some Indian medicine doctors that may practice something similar. The problem is that the type of insight (not to mention range of products that they know about) could be rather limited. What's "oxitocinergics" mean?

In terms of pharmaceutical variations of entheogens, that's a great idea too. Pharmaceutical giants like Pfizer are mainly motivated by profit/greed and casting misconceptions so that's why these corporate entities haven't churned out very useful products over the last 60 some years.

Next Entheogen:
Galantamine-extract from the bulbs and flowers of the Caucasian snowdrop (Voronov's snowdrop), Galanthus woronowii (Amaryllidaceae) and related genera like Narcissus (daffodil), Leucojum (snowflake) and Lycoris including Lycoris radiata (Red Spider Lily). This was something even anceint greeks used to improve memory (much later Galantamine was discovered to be the chemical responsible for this effect); now it's a known ACH inhibitor and nicotinergic agonist.

Over the past 10 years Galantamine (a known entheogen) has finally had a pharmaceutical variation released. This is known as reminyl or razadyne depending on the country you buy it from (note for anyone reading this unfamiliar with Galantamine razadyne is the american pharmaceutical name that has nothing to do with rasagline, which is a totally different drug). Galantamine can be bought in less potent supplement based forms as well (these are the forms you'll see at various nootropic sites that don't sell pharmaceuticals).

There are some manufacturers that seem to combine various herbal extracts that may be used to brew a sort of tea. The effect acheived from this could be considerably weak or somewhat noticeable (I'm not sure). One such company may be http://www.tea-corpo...bal-extract.htm (various chemicals including galantamine are listed here).

I'm unsure on whether Galantamine can have a psycho-active effect thru means other than ingesting (some type of herbal tobacco used by certain cultures that may have trace amounts in it for example).

One thing I'd like to add to my previous entry regarding lobeline:
"Lobeline is a natural alkaloid found in "Indian tobacco" (Lobelia inflata), "Devil's tobacco" (Lobelia tupa), "cardinal flower" (Lobelia cardinalis), "great lobelia" (Lobelia siphilitica), and Hippobroma longiflora. In its pure form it is a white amorphous powder which is freely soluble in water." http://en.wikipedia.org/wiki/Lobeline

Smokable forms:
Indian Tobocco (lobelia inflata): http://www.purplesag...diantobacco.htm
http://www.ct-botani...obeliainfl.html
http://www.herbalsmo...oking-herbs.php (herbal tobacco spelled out as
"lobelia inflate" instead of "lobelia inflata" for some reason); not sure if there's an actual
noticeable effect from this

Devils Tobacco (lobelia tupa): http://www.rareplant...t.asp?P_ID=8347 (sold in euros)

Sublingual forms:
This is the form of lobeline undergoing clinical trials. http://clinicaltrial...how/NCT00664703 (note that the company doing this is the same company I linked to in my previous post that's trying to test it for amphetamine as well as nicotine addiction besides their adhd trials)

Edited by yowza, 16 June 2009 - 01:33 AM.


#4 spaceistheplace

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Posted 16 June 2009 - 02:29 AM

I take 100mg of sceletium tortuosum every day. It's said to be 10x more potent than St. John's wort but i'm not so sure. It increases my mood very slightly, and the effect is definitely not nootropic.

#5 yowza

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Posted 16 June 2009 - 03:53 AM

I take 100mg of sceletium tortuosum every day. It's said to be 10x more potent than St. John's wort but i'm not so sure. It increases my mood very slightly, and the effect is definitely not nootropic.


Rapid fire questions (meaning more info. please?): Is there a doctor that prescribes this to you or do you order it online? Do you smoke it? Could you describe the potency of mesembrine in the Sceletium Tortuosum that you use? Including as much info. about this as is relevant in a single post would really help alot.

The main reason I put this as a nootropic is due to it's main mechanism being PDE4 inhibition. PDE4 inhibition is one of the main mechanisms that's being looked into for increasing intracellular cAMP levels.

#6 Guacamolium

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Posted 16 June 2009 - 04:15 AM

Damn, I mistook entheogen for entactogen when I made that statement.

Oxytocinergic was just a word I made up to refer to a class of drugs that dealt with oxytocin agonists, inverse-agonists, or antagonists; which I don't believe explicitly exists yet as a class. I just made it up in the fashion that scientists refer to serotonergic/glutamatergic/dopaminergic/GABA-ergic/cholinergic, etc.

Well damn, I just looked up the word and it actually exists - I didn't make it up after all..... :(

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#7 yowza

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Posted 16 June 2009 - 09:35 AM

Damn, I mistook entheogen for entactogen when I made that statement.

Oxytocinergic was just a word I made up to refer to a class of drugs that dealt with oxytocin agonists, inverse-agonists, or antagonists; which I don't believe explicitly exists yet as a class. I just made it up in the fashion that scientists refer to serotonergic/glutamatergic/dopaminergic/GABA-ergic/cholinergic, etc.

Well damn, I just looked up the word and it actually exists - I didn't make it up after all..... :(


That sounds pretty interesting. While I'm not sure that all those oxcitonergics are entheogenic based, it would be interesting to hear about them somehow...

The whole entactogen and entheogen thing can be kind of confusing so I'll try and clear this up for anyone whose interested.

Entactogen vs. Entheogens:
I'm aware that "entheogen" seems to be a term discussed pre-dominantly in the recreational drug community as opposed to the nootropics community. These 2 areas definitely overlap in many areas but the philosophy+goal behind each is different. Hence the reason why most discussions on a research chem. forums or entheogen forum usually turn to recreational drug use (getting high, wasted, experiencing an occasional altered state, ect.) unfortunately.

1) Here's the definition of entheogens (http://en.wikipedia.org/wiki/Entheogen):

An entheogen ("creates god within," en- "in, within," theo- "god, divine," -gen "creates, generates"),[1] in the strictest sense, is a psychoactive substance used in a religious or shamanic context. Historically, entheogens are derived primarily from plant sources and have been used in a variety of traditional religious contexts.

From what I've been able to read about Entactogens, the one's listed aren't entheogens but various synthesized chemicals.


With the advent of organic chemistry, there now exist many synthetic substances with similar properties.


Strictly speaking, I'd probably not consider this last portion to be entheogenic unless it was derived from a natural substance or synthetically created to mimic a natural substance. However, some people may see things differently and go by a more broadened definition (maybe fitting just the first sentence of the definition above). I'm not sure, but erowid (a database listing many entheogenic compounds) could go with this more generalised interpreation in some parts.

Overlapping definition of "entheogen" with definition of "nootropic":
With this thread, I'm not strictly going by the definition of entheogen however. Instead, I'm looking at an "entheogen" and seeing what "entheogens" can overlap into the "nootropics" area (http://en.wikipedia.org/wiki/Nootropic). This is kind of subjective based so I suppose we'll have to make our own interpretations (assuming anyone is interested in this thread of course).

2) Entactogen/Empathogen:

The term "empathogen" was coined in 1983 by Ralph Metzner to denote chemical agents inducing feelings of empathy. "Entactogen" was coined by David E. Nichols as an alternative to "empathogen", attempting to avoid the potential for improper association of the latter with negative connotations related to the Greek root "pathos" (suffering); Nichols also thought the word was limiting, and did not cover other therapeutic uses for the drugs that go beyond instilling feelings of empathy. The word "entactogen" is derived from the roots "en" (Greek: within), "tactus" (Latin: touch) and "gen" (Greek: produce) (Nichols 1986: 308). Neither term is dominant in usage, and, despite their difference in connotation, are essentially interchangeable, as they refer to precisely the same chemicals.


A somewhat more limited view of the term "entactogen":

The terms empathogen and entactogen are used to describe a class of psychoactive drugs that produce distinctive emotional and social effects similar to those of MDMA ("Ecstasy"). Putative members of this class include MDMA, MDA, MDEA, MBDB, and AET, among others. The chemical structure of most entactogens contains a substituted amphetamine core, and most belong to the phenethylamine class of psychoactive drugs. When referring to MDMA and its counterparts, the term 'MDxx' is often used with the exception of MDPV. Entactogens are often incorrectly referred to as major hallucinogens or stimulants, although their effects are often somewhat characteristic of such.


Trying to overlap entactogen with entheogen with nootropic definition?:
As you can see, some of these analogues (more are listed at the wiki link of http://en.wikipedia....wiki/Entactogen) aren't entheogens. However, some of these are entheogens (LSD is an ergoline; besides being plant derived, it also fits the general definition for entheogen posted above too) so some can overlap under the category of "entheogen".

However, none of the drugs commonly listed as entactogens would fall under the category of nootropic in my opinion since they couldn't be used daily use, can be damaging, along with several other reasons. However, this isn't to say that someone couldn't take the generalized meaning of "entactogen" and find a nootropic that one could see as empathogen like.

Unfortunately, this just doesn't seem to be how this term is commonly used (instead it seems to have a very specific meaning outlined above). For ex., for oxytocine I'd personally consider this a nootropic that overlaps into the entactogen realm. The only problem is that the term "entactogen" just doesn't seem to commonly be used in the general sense (as noted above). Also, with oxytocine being a peptide compound synthesized by the body, I wouldn't say this compound could fall under the entheogen catagory either (however, it could possibly fit within a more generalized definition of entheogen since in a way you could say that increasing your empathy/affective level definitely could be seen as creating "the god within"). Therefore, if one were to go with a more generalized definition of entactogen and really stretch the definition of entheogen, I suppose it could be possible to consider oxytocine under both categories. I'd also consider "oxytocine" a nootropic without really stretching or broadening the definition at all (hence, making up a term such as oxcitonergic actually does go in line with the whole method by which nootropics tend to be classified such as dopamergic, serotonergic, ect.).

I don't mean to change the course of this thread, just pointing some things out to clear up my own confusion and hopefully any others too. :|w

Edited by yowza, 16 June 2009 - 09:41 AM.

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