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Oxiracetam Mega-dose experience (12 grams)


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#1 Steve_86

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Posted 12 June 2009 - 03:19 PM


First of all I just want to say that I am aware that taking 12 grams of Oxiracetam is potentially dangerous.

This semester there were circumstances that led me to fall behind significantly in my university studies. I managed to keep up for the most part except for one unit where I was literally 6 weeks behind with two nights left before the exam.

The night before the exam I took about 12 grams of Oxiracetam plus some caffeine and 10mg of dexamphetamine to help stay awake. The oxiracetam was taken in 3.2 gram doses spaced 1-2 hours apart. While studying I felt little to no effect from the Oxiracetam. The next day after just 2 hours of sleep I sat my exam. My memory was the best it has ever been. I remembered many paragraphs of text almost word for word and my memory of diagrams/images was extremely detailed as well. Considering how content I covered in one night I was quite amazed with my recall.

I have tried Piracetam and Anaracetam, but neither came close the the memory boosting effects of Oxiracetam. I wouldn't plan on doing this often at all, but when it comes to cramming for an exam caffeine+oxi seems unbeatable. Is there any actual evidence to suggest that this could be significantly dangerous?

Has anyone else tried such high dosages?

Edited by Steve_86, 12 June 2009 - 03:26 PM.


#2 Imagination

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Posted 12 June 2009 - 10:38 PM

Expensive to do! Not actually tried any other racetam than piracetam, going to be experimenting with ani and oxi soon though. I have heard oxi is great for a quick hit and really boosting your brain power but is quickly followed by a crash afterwards. But people say that they have amazing recall from the 2-3 hour period after taking the oxi. Going to go with ani first I think, give that a go. Never really got too much out of piracetam to be honest, don't think i will bother with it again. Did you notice the ani being better than the piracetam?

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#3 Guacamolium

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Posted 13 June 2009 - 08:37 AM

"First of all I just want to say that I am aware that taking 12 grams of Oxiracetam is potentially dangerous."

Not really. You'll just go way over the "sweet spot" that oxiracetam would have given you otherwise if you would have had the sense to dose accordingly. We're not talking about Deprenyl here...
Now if you do that over and over again - then the potentially dangerous part comes in to play. Dose-response/bell curve - that plays a good role in that.

Edited by somethingtoxic, 13 June 2009 - 08:38 AM.


#4 Steve_86

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Posted 13 June 2009 - 09:06 AM

"First of all I just want to say that I am aware that taking 12 grams of Oxiracetam is potentially dangerous."

Not really. You'll just go way over the "sweet spot" that oxiracetam would have given you otherwise if you would have had the sense to dose accordingly. We're not talking about Deprenyl here...
Now if you do that over and over again - then the potentially dangerous part comes in to play. Dose-response/bell curve - that plays a good role in that.


For all I know 12grams is the sweet spot for me. My memory was immaculate and side effects were non-existent. I'll have to do more experimentation thou.

#5 Guacamolium

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Posted 15 June 2009 - 06:47 AM

"First of all I just want to say that I am aware that taking 12 grams of Oxiracetam is potentially dangerous."

Not really. You'll just go way over the "sweet spot" that oxiracetam would have given you otherwise if you would have had the sense to dose accordingly. We're not talking about Deprenyl here...
Now if you do that over and over again - then the potentially dangerous part comes in to play. Dose-response/bell curve - that plays a good role in that.


For all I know 12grams is the sweet spot for me. My memory was immaculate and side effects were non-existent. I'll have to do more experimentation thou.


I took 4 grams on accident. (long story) and yes, it did have about a 30 minute period where I was on the ball like never before, but soon the over-focus kicked in and I was stupefied like nothing else. If 12 grams is your sweet spot, then that kinda sucks price-wise, but glad you found it. I'm skeptical though. I think you're overdosing your racetam - hopefully you've a cholinergic that can keep up with that kind of dose.

#6 Steve_86

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Posted 15 June 2009 - 03:30 PM

"First of all I just want to say that I am aware that taking 12 grams of Oxiracetam is potentially dangerous."

Not really. You'll just go way over the "sweet spot" that oxiracetam would have given you otherwise if you would have had the sense to dose accordingly. We're not talking about Deprenyl here...
Now if you do that over and over again - then the potentially dangerous part comes in to play. Dose-response/bell curve - that plays a good role in that.


For all I know 12grams is the sweet spot for me. My memory was immaculate and side effects were non-existent. I'll have to do more experimentation thou.


I took 4 grams on accident. (long story) and yes, it did have about a 30 minute period where I was on the ball like never before, but soon the over-focus kicked in and I was stupefied like nothing else. If 12 grams is your sweet spot, then that kinda sucks price-wise, but glad you found it. I'm skeptical though. I think you're overdosing your racetam - hopefully you've a cholinergic that can keep up with that kind of dose.


I had 1 gram of 50% Alpha GPC with it and felt no negative effects what so ever. I think my choline levels are naturally high thou, I have always been fine using racetams without it. More than 1 gram of 50% Alpha GPC makes me feel tense.

#7 Guacamolium

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Posted 15 June 2009 - 08:02 PM

"First of all I just want to say that I am aware that taking 12 grams of Oxiracetam is potentially dangerous."

Not really. You'll just go way over the "sweet spot" that oxiracetam would have given you otherwise if you would have had the sense to dose accordingly. We're not talking about Deprenyl here...
Now if you do that over and over again - then the potentially dangerous part comes in to play. Dose-response/bell curve - that plays a good role in that.


For all I know 12grams is the sweet spot for me. My memory was immaculate and side effects were non-existent. I'll have to do more experimentation thou.


I took 4 grams on accident. (long story) and yes, it did have about a 30 minute period where I was on the ball like never before, but soon the over-focus kicked in and I was stupefied like nothing else. If 12 grams is your sweet spot, then that kinda sucks price-wise, but glad you found it. I'm skeptical though. I think you're overdosing your racetam - hopefully you've a cholinergic that can keep up with that kind of dose.


I had 1 gram of 50% Alpha GPC with it and felt no negative effects what so ever. I think my choline levels are naturally high though, I have always been fine using racetams without it. More than 1 gram of 50% Alpha GPC makes me feel tense.


1fast400 brand i assume... I take Source Naturals Alpha-GPC and price per mg is better - and you have 100% A-GPC. It rocks! Easily in my top 5 with Oxiracetam. It could be high levels of acetylcholine that you have as your set-limit for one of the most efficacious racetams which doesn't deplete enough to cause memory problems. If you start to have memory retrieval problems, then up the cholinergic - whatever you choose it to be.

I once took a combo of piracetam and DMAE, and the DMAE ran out but I continued taking the piracetam - about a week or so later, I went into full-blown amnesia - forgetting complete conversations with people. Once I added a cholinergic back into the stack, it went away. DMAE causes tenseness in me BTW, but all other straight cholinergics do not. YMMV as we've already seen, but I still insist on you keeping cholinergics on hand, perhaps choline citrate - a cheap one - just in case. CDP-choline might not give you the tense feelings that APGC does. I have noticed that a small minority of people regard CDP-choline as better than AGPC as their premium cholinergic. The others use Acetylcholinesterase inhibitors like memantine or hup-A to get the job done.

12 grams!!!!??? I actually may try that sometime just to experiment, but the bell curve tells me otherwise. I once took 6 to 7 grams of piracetam, and that was WAY too much. Bad times...

#8 mcollard

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Posted 04 July 2009 - 01:44 PM

Do you mean 12 grams of a racetam, or 12 grams of a suspension?

The reason I ask is that I believe the use a cellulose filler and 12 grams of suspension is fewer grams of actual product.

#9 Guest_Isochroma_*

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Posted 10 August 2009 - 12:40 AM

After extensive searching I cannot even find a mention anywhere of Oxiracetam toxicity. Not in all of Google anyway. I did find a study where it was fed to beagles, yes those cute weiner-dog doggies :p

Too bad the abstract isn't available: 52 week oral toxicity study of oxiracetam in beagle dogs with a recovery period of 8 weeks

So it seems the only danger of large doses of Oxiracetam - like so many other racetams - is to your wallet.

Warning: excessive dosages of Oxiracetam may cause thinning, shrinkage or total disappearance of your wallet.

Edited by Isochroma, 10 August 2009 - 12:42 AM.


#10 Guest_Isochroma_*

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Posted 30 August 2009 - 01:19 AM

After more research I found out that Oxiracetam is not metabolised at all - just like Piracetam. Those cute little molecules come and go without ever being altered, thus Oxiracetam is as safe as Piracetam.

"In all species the systemically available radioactivity was nearly exclusively excreted in urine in the form of unmetabolized oxiracetam."

Absorption and disposition of 14C-labelled oxiracetam in rat, dog and man



#11 magellan

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Posted 07 January 2010 - 09:26 PM

works pretty good to hit sweet spot for some racetams
12 grams is pretty awesome risky and effective
I prefer attack dose piracetam as daily dose
combined with other brain building strategies works best

#12 HMan

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Posted 09 January 2010 - 03:42 PM

Steve 86, please let us know how you did on your exams, ;)

#13 RighteousReason

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Posted 09 January 2010 - 06:29 PM

First of all I just want to say that I am aware that taking 12 grams of Oxiracetam is potentially dangerous.

This semester there were circumstances that led me to fall behind significantly in my university studies. I managed to keep up for the most part except for one unit where I was literally 6 weeks behind with two nights left before the exam.

The night before the exam I took about 12 grams of Oxiracetam plus some caffeine and 10mg of dexamphetamine to help stay awake. The oxiracetam was taken in 3.2 gram doses spaced 1-2 hours apart. While studying I felt little to no effect from the Oxiracetam. The next day after just 2 hours of sleep I sat my exam. My memory was the best it has ever been. I remembered many paragraphs of text almost word for word and my memory of diagrams/images was extremely detailed as well. Considering how content I covered in one night I was quite amazed with my recall.

I have tried Piracetam and Anaracetam, but neither came close the the memory boosting effects of Oxiracetam. I wouldn't plan on doing this often at all, but when it comes to cramming for an exam caffeine+oxi seems unbeatable. Is there any actual evidence to suggest that this could be significantly dangerous?

Has anyone else tried such high dosages?

Dude, that's awesome.

#14 Steve_86

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Posted 17 January 2010 - 06:46 AM

Steve 86, please let us know how you did on your exams, :)


Hi, I'm sorry for the late response. I didn't notice your reply.

I got 78% in the exam for the unit that I was 6 weeks behind in. I think it's a phenomenal result considering how far behind I was. I honestly thought I was doomed. While studying I didn't feel any smarter, however the following day during my exam I noticed my memory was freakishly good.

Edited by Steve_86, 17 January 2010 - 06:47 AM.


#15 Shay

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Posted 17 January 2010 - 03:28 PM

Steve 86, please let us know how you did on your exams, :)


Hi, I'm sorry for the late response. I didn't notice your reply.

I got 78% in the exam for the unit that I was 6 weeks behind in. I think it's a phenomenal result considering how far behind I was. I honestly thought I was doomed. While studying I didn't feel any smarter, however the following day during my exam I noticed my memory was freakishly good.



I'd love to know how well you recall today all that info you crammed last year, and also compared to your typical recall at this late date.

#16 jtinktank

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Posted 18 January 2010 - 08:25 PM

I just posted a thread on high dose oxiracetam, which was inspired by this topic.

http://www.imminst.o...mp;#entry376928

What are the symptoms of an overdose of oxiracetam?

I had a really important exam today... FRIGHTENINGLY IMPORTANT. Naturally, I was ill prepared.

I stumbled upon this thread: Oxiracetam Mega-dose experience (12 grams), cramming for an exam
http://www.imminst.o...mp;#entry374726
I was convinced this would work for me.

I spent the whole of last night revising and still hadn't finished. Armed with caffeine (red bull), Alpha GPC and a large supply of Oxiracetam, I went to work.
I took somewhere between 10 and 14...make it 16g Oxiracetam. While i was revising everything was great. I was remembering things and learning things really quickly.

Then I went to bed for 4 hours. I woke up and the trouble began. I couldn't remember a damn thing! I couldn't remember mechanisms (Organic Chemistry exam), processes... NOTHING. I would look at starting reactions and could not complete them.

I had a hint of confidence towards the exam. I kept reminding myself that I took Oxiracetam and that things would be a lot better that i thought; I was somehow convinced that i would have this amazing 'photographic memory' because of the high dose. Then I read the questions. I gave up. I walked out 30mins after the exam started (the exam was 2 hours). That was the first time I have ever walked out of an exam and it will be my LAST!

My initial response to Oxi was positive. A slight buzz with memory and faster learning.

Did I overdose or did I fail because of sleep deprivation?

The problem is... I have an exam tomorrow of equal importance. Do I take Oxiracetam? Do I dare touch the stuff after last night? LOWER DOSE maybe?

I've got aniracetam... It makes me slightly drowsy. It doesn't feel as good as oxiracetam. I've also got pramiracetam but have never tried it. I need to take something (I have 1 exam tomorrow and another on Wednesday). What would you do?


Edited by jtinktank, 18 January 2010 - 08:27 PM.


#17 Steve_86

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Posted 19 January 2010 - 09:25 AM

I just posted a thread on high dose oxiracetam, which was inspired by this topic.

http://www.imminst.o...mp;#entry376928


I'm sorry that Oxiracetam did not help you. Do you really think the Oxi made you perform worse or fail, or were you going to fail regardless?

If you think it had a negative impact on your exam performance then you would be crazy to take it a second time.

#18 jtinktank

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Posted 20 January 2010 - 08:15 PM

If you think it had a negative impact on your exam performance then you would be crazy to take it a second time.


Crazy...maybe. Necessary... definitely. I took less that 3g on the subsequent days; of which, i felt less of an effect during the studying and I think during the exams. It's not so much the oxiracetam but the dose. I definitely over did it! It went over what Somethingtoxic would call the 'sweet spot'. I realise this, and learnt from it. I can't say that I won't do it again. I can say that I'll think more about what I'm putting into my body during times of panic.

I think that going to bed between revising and taking the exam had an effect. Making my mind rest was the mistake. I think after being overwhelmed, my brain tried to get to grips with what was going on while sleeping, unfortunately this was to my detriment... or was it?

Thanks for your thread. I'll keep you posted on any other scares!

#19 Steve_86

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Posted 29 January 2010 - 05:15 AM

If you think it had a negative impact on your exam performance then you would be crazy to take it a second time.


Crazy...maybe. Necessary... definitely. I took less that 3g on the subsequent days; of which, i felt less of an effect during the studying and I think during the exams. It's not so much the oxiracetam but the dose. I definitely over did it! It went over what Somethingtoxic would call the 'sweet spot'. I realise this, and learnt from it. I can't say that I won't do it again. I can say that I'll think more about what I'm putting into my body during times of panic.

I think that going to bed between revising and taking the exam had an effect. Making my mind rest was the mistake. I think after being overwhelmed, my brain tried to get to grips with what was going on while sleeping, unfortunately this was to my detriment... or was it?

Thanks for your thread. I'll keep you posted on any other scares!


Thats interesting because I felt that a few hours of sleep helped consolidate the memories. Before going to bed I felt like I had information overload but upon waking everything had settled in nicely. I don't know if it would have made any difference but I also took another dose of a few grams immediately upon waking. I wonder what my sweetspot is and why oxi works so much better than piracetam or aniracetam for me.

#20 victortsoi

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Posted 11 August 2012 - 11:52 PM

I'd like to re-animate this thread...I can believe taking that much oxi to cram...the "peak" effect runs out pretty quickly, but is great while its there. Almost like caffeine or adderall but for about 40-70 minutes worth for the "peak"

#21 ScienceGuy

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Posted 13 August 2012 - 09:04 AM

My two cents:

Firstly, choosing to carry out such experimentation the night before an important examination is nothing short of CRAZY... and some people think I'm a bit nuts... sheez! :laugh:

My advice to anyone even thinking of experimenting along the lines of such high doses of OXIRACETAM is to do a trial run first, using say a practice exam paper downloaded off of the Internet, or at the very least an IQ test, to see how you perform cognitively the morning after taking such a high dose the night before. ;)

The fact that the RACETAMS can greatly vary from person to person with regards to how one responds is even more reason not to take such an insane gamble at such a crucial time of your life. :|o

Furthermore, there seems to be considerable variance with regards to an individual's CHOLINE requirements when it comes to RACETAM usage, including OXIRACETAM, and as such one needs to ascertain exactly what is the right CHOLINE dosage for YOU; and since the dosage of CHOLINE required to 'fuel' the respective RACETAM will tend to increase with the dosage of RACETAM taken logic dictates that if you choose to take 12 grams of OXIRACETAM, this would need to be accompanied by whatever dosage of CHOLINE that YOU personally require to 'fuel' the 12 grams OXIRACETAM, which can be deduced from whatever dosage of CHOLINE is required to prevent the manifestation of CHOLINE DEFICIENCY SYMPTOMS (BRAIN FOG, MEMORY LOSS etc.) :)

Steve_86's anecdotal report seems to indicate that for Steve_86 taking 0.5g ALPHA-GPC was for him sufficient for the 12 grams OXIRACETAM dosage and he was able to tolerate that high a dosage without any problem. However, it seems abundently obvious that the same cannot be said of Jtinktank, wherein the subsequent stupifying the next morning could very well have been induced the CHOLINE supply being depleted and hence an ANTI-CHOLINERGIC reaction occurred, or there was some other issue wherein said symptoms occurred.

Hence, my advice for the crazy people out there wishing to try this out is firstly, to do a practice run first (i.e. don't attempt it for the first time the night before an important exam); and secondly, pay attention to vital factors such as CHOLINE requirements, wherein you might need to adjust your CHOLINE dosage in the instance of manifestation of CHOLINE DEFICIENCY SYMPTOMS, including BRAIN FOG, MEMORY LOSS etc. ;)
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#22 medievil

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Posted 13 August 2012 - 10:30 AM

^^ There's no evidence that racetams need a choline source, nor that they deplete choline, there is however evidence for synergie wich is differened from a "required add on", choline sources can have depressive side effects for many and racetams should be tried on their own first.
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#23 ScienceGuy

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Posted 13 August 2012 - 11:12 AM

^^ There's no evidence that racetams need a choline source, nor that they deplete choline, there is however evidence for synergie wich is differened from a "required add on", choline sources can have depressive side effects for many and racetams should be tried on their own first.


You are indeed correct with regards to there not being substantiated clinical studies along these lines, however I am sure that you will acknowledge the many, many anecdotal reports from users of RACETAMS to the extent that it is an accepted fact that CHOLINE is a necessary COFACTOR. :)

RE: "choline sources can have depressive side effects for many and racetams should be tried on their own first" - I wholehearted agree. Unfortunately, in my experience the 'sweet spot' with regards to CHOLINE dosage, firstly varies considerably from person to person, and secondly sits on a very narrow threshold between what is too little, wherein occurs the manifestation of CHOLINE defiiciency symptoms, and too much wherein occurs the manifestation of side effects associated with too high CHOLINE / ACH levels, such as DEPRESSION, MOOD SWINGS, HEADACHE, MUSCLE TENSION, INCREASED SWEATING etc... My advice would usually be to do as you say and try it without initially, and then add CHOLINE starting at a very low dosage of say 100mg CHOLINE and then increase gradually by say 100mg increments until said 'sweet spot' is deduced. ;)

However, please note that this thread is specifically talking about taking very high doses of OXIRACETAM; and hence in my opinion the requirement for at least some supplemental CHOLINE is almost a certaintly; as such my advice is that an appropriate dosage of CHOLINE be taken concurrently that is estimated by the particular individual from whatever is their usual amount of CHOLINE that they take concurrently with their usual dosage of OXIRACETAM. If you find that you can take 800mg TID of OXIRACETAM without needing any CHOLINE whatsoever then by all means try taking 12 grams OXIRACETAM without any CHOLINE, but you should be prepared to add some CHOLINE if you experience CHOLINE DEFICIENCY SYMPTOMS when doing so :)

Edited by ScienceGuy, 13 August 2012 - 11:15 AM.

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