If you've read some of the excellant works of Dr. Dilman, he clearly explains that increasing hypothalamic neurotransmitters to youthful levels can remove some effects of ageing. AD drugs and many psychedelics have an endocrinal impact. TCAs can increase melatonin synthesis (pineal grafts can even reverse menopause) Serotonin antagonists (Mianserin(Bolvidon), Mirtazapine(Remeron), aglometerine) have already shown to extend lives in worms. Chronic AD's reduce cortisol and this may increase lipespans. Lithium (and valproate and many anti-epileptics) and SSRI's and serotonin1A agonists (2A/2C antagonists) have robust neuroprotective and neurogenic effects, Lithium in particular inspite of a mood darkening "stabilising" effect; some people even take a low-dose Lithium. Of course Selegiline has undoubtable pro-longevity effects Phenytoin and Tianeptine(Stablon) reverse stress injury to the brain. There is no systematic study of AD's in life-extension, yet agents that increase lifespans are often antidepressive. So nature may want us to live "happy" ever after. I've wondered for long that we are overlooking AD's for LE. If you are optimistic do name some antidepressants that you think would lifespans, cite studies and being pragmatic name only AD's used or in trials to be used. Somewhat over-prescribed in cancer too, millions today have been taking ADs (antidepressants) for over a decade now!
Do Antidepressants increase / alter lifespan? Which?
#1
Posted 21 July 2009 - 05:13 PM
If you've read some of the excellant works of Dr. Dilman, he clearly explains that increasing hypothalamic neurotransmitters to youthful levels can remove some effects of ageing. AD drugs and many psychedelics have an endocrinal impact. TCAs can increase melatonin synthesis (pineal grafts can even reverse menopause) Serotonin antagonists (Mianserin(Bolvidon), Mirtazapine(Remeron), aglometerine) have already shown to extend lives in worms. Chronic AD's reduce cortisol and this may increase lipespans. Lithium (and valproate and many anti-epileptics) and SSRI's and serotonin1A agonists (2A/2C antagonists) have robust neuroprotective and neurogenic effects, Lithium in particular inspite of a mood darkening "stabilising" effect; some people even take a low-dose Lithium. Of course Selegiline has undoubtable pro-longevity effects Phenytoin and Tianeptine(Stablon) reverse stress injury to the brain. There is no systematic study of AD's in life-extension, yet agents that increase lifespans are often antidepressive. So nature may want us to live "happy" ever after. I've wondered for long that we are overlooking AD's for LE. If you are optimistic do name some antidepressants that you think would lifespans, cite studies and being pragmatic name only AD's used or in trials to be used. Somewhat over-prescribed in cancer too, millions today have been taking ADs (antidepressants) for over a decade now!
#2
Posted 22 July 2009 - 12:01 PM
If you've read some of the excellant works of Dr. Dilman, he clearly explains that increasing hypothalamic neurotransmitters to youthful levels can remove some effects of ageing. AD drugs and many psychedelics have an endocrinal impact. TCAs can increase melatonin synthesis (pineal grafts can even reverse menopause) Serotonin antagonists (Mianserin(Bolvidon), Mirtazapine(Remeron), aglometerine) have already shown to extend lives in worms. Chronic AD's reduce cortisol and this may increase lipespans. Lithium (and valproate and many anti-epileptics) and SSRI's and serotonin1A agonists (2A/2C antagonists) have robust neuroprotective and neurogenic effects, Lithium in particular inspite of a mood darkening "stabilising" effect; some people even take a low-dose Lithium. Of course Selegiline has undoubtable pro-longevity effects Phenytoin and Tianeptine(Stablon) reverse stress injury to the brain. There is no systematic study of AD's in life-extension, yet agents that increase lifespans are often antidepressive. So nature may want us to live "happy" ever after. I've wondered for long that we are overlooking AD's for LE. If you are optimistic do name some antidepressants that you think would lifespans, cite studies and being pragmatic name only AD's used or in trials to be used. Somewhat over-prescribed in cancer too, millions today have been taking ADs (antidepressants) for over a decade now!
#3
Posted 22 July 2009 - 04:05 PM
#4
Posted 22 July 2009 - 05:57 PM
http://brainhealthha...your-life-span/
where they say that SSRI's are bad, serotonin antagonists fair better but it's equivocal. A lot of sites have come up this way, this one is not especially good though it's unfair to say I hate negatives just because I'm flesh and blood. However, wiki and a nature publication(+ve for Mianserin(31%) , Lithium(46%), Selegiline(25-40%) which no doubt increases catecholamines(Dr. Knoll's work) is rather trustworthy. Lithium low doses seem to be prophylactic in neurodegenerative diseases like Alzheimer's. Let's keep it going.
#5
Posted 24 July 2009 - 05:26 PM
another one favoing serotonin antagonists is this one http://www.plosone.o...al.pone.0004062
#6
Posted 24 July 2009 - 11:19 PM
#7
Posted 25 July 2009 - 08:36 AM
#8
Posted 25 July 2009 - 03:37 PM
Edited by Psych, 25 July 2009 - 03:38 PM.
#9
Posted 25 July 2009 - 04:24 PM
And secondly, what??? You're all over the place. To start a poll, just click the underlined sentence saying "Click here to manage this topic's poll options" when starting a thread. Only a navigator can do that to an already-started thread, AFAIK.
#10
Posted 25 July 2009 - 05:04 PM
What do we know about St. John's Wort, specifically hyperforin?
#11
Posted 25 July 2009 - 05:38 PM
#12
Posted 25 July 2009 - 06:58 PM
#13
Posted 25 July 2009 - 08:43 PM
Try to formulate a point in your mind, state it, then substantiate it with technical details. I think there's some intelligence buried in your posts, but it looks more like coprolaila from a kid who was taught ligands instead of swear words. I'm not trying to be mean, it just makes you impossible to understand.
#14
Posted 26 July 2009 - 09:24 AM
#15
Posted 26 July 2009 - 06:24 PM
You talk a lot about countering the aging hormonal changes; but i'm not sure this usually extends lifespan. Typically, if the effects of hormonal replacement therapies were clearly extending women's lifespans we would know it well. Same with human growth hormon.
You seem to talk about "pro-longevity" effects of some drugs; namely lithium and those:
are you referring to rodent studies? human studies? ThanksMetformin supposedly increases the sensitivity, we already know it's pro-long life. (...) Mirtazapine(Remeron) and the appetizer Cyproheptadine (Periactin) are strong 5HT-2C antagonists, suggesting a cause why they extend life in studies.
#16
Posted 06 August 2009 - 09:28 AM
http://brainhealthha...your-life-span/
http://www.plosone.o...al.pone.0004062
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