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rosetta@home update


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9 replies to this topic

#1 ihatesnow

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Posted 12 August 2009 - 11:40 AM


http://boinc.bakerla...p?id=1177#62409

#2 ihatesnow

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Posted 17 August 2009 - 10:54 AM

http://www.medicalne...cles/130827.php

#3 Ghostrider

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Posted 18 October 2009 - 04:12 AM

http://www.medicalne...cles/130827.php


Yeah, that's why I still run Rosetta@Home over Folding. I feel the impact factor is currently higher with Rosetta (by impact factor I mean results / computational effort). I feel that FAH has perhaps a more general goal and they have done impressive things with GPUs (which is actually part of the reason why I don't fold on FAH -- one PS3 can do more work in one hour than my Core2 laptop can accomplish in at least 12 hours. So I'll leave the PS3 works for the more efficient PS3s and GPUs). Rosetta does not have that option so my work units go further there. Also, I wish FAH talked more about the significance of their work on a weekly or monthly basis. A good example of what I would like to see from them would be this:

We just learned that a model we had generated using the "fold and dock" method on your computers allowed the solution of the phase problem for structural biologists who had grown crystals of the (dimeric) protein but not been able to solve its structure--this result led to a huge flurry of email today as the approach could be very useful for a broad class of problems.

As I mentioned earlier, the paper on the "fold and dock" protocol (which you can recognize by the symmetric dancing of molecules on your screensaver) was enthusiastically accepted for publication in the proceedings of the national academy of sciences and will be free on line soon. Here is one of the anonymous reviews of the manuscript:

"The authors introduce a simultaneous "fold and dock" routine for the prediction of symmetric systems with impressive results. The method combines the Rosetta folding algorithm and the lab's more recent symmetric docking protocol. Here, both the backbone moves and relative positioning of the components are accomplished in the same Monte Carlo routine. Undoubtedly, this feature is necessary for most of the systems, particularly those which are intertwined. The authors both benchmark their results and even include a few predictions (using structures that came out after simulations). In addition they test the utility of the method for ab initio phasing and structure prediction incorporating some NMR-based constraints. This is an extremely nice piece of work which addresses an outstanding challenge in structural biology and protein structure prediction."

http://boinc.bakerla...ead.php?id=1177


Wow! Sounds like progress!

Both projects are great and I hope they succeed. Overall, I feel FAH has contributed more to distributed computing / GPGPU development. It sounds like they have a more general goal as well and have published more papers. But they are also using more resources to do so.

#4 ihatesnow

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Posted 08 March 2010 - 01:10 PM

http://boinc.bakerla...ead.php?id=1177

#5 ihatesnow

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Posted 21 April 2010 - 03:09 PM

http://boinc.bakerla...h...4408&sort=5

#6 ihatesnow

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Posted 17 May 2010 - 11:11 PM

http://boinc.bakerla...ead.php?id=4477

#7 Ghostrider

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Posted 18 May 2010 - 08:03 AM

http://boinc.bakerla...ead.php?id=4477


Humm...I was going to shut off my computer tonight, but now I think I'll leave it running.

#8 ihatesnow

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Posted 18 May 2010 - 09:16 AM

http://boinc.bakerla...ead.php?id=4477


Humm...I was going to shut off my computer tonight, but now I think I'll leave it running.



together we are like one big supercomputer

#9 ihatesnow

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Posted 04 August 2010 - 11:38 PM

http://news.cnet.com...012675-247.html



#10 ihatesnow

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Posted 21 October 2012 - 07:07 AM

new from rosetta@home October 2012


http://boinc.bakerla...ead.php?id=1177




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