I've got another Q for anyone who might have the information, and I assume the answer is yes but, the liquid can be absorbed through the stomach just as well as the mouth right? I mean, the tablet obviously goes through the digestive./ GI tract/ liver, so if we swallowed liquid dep would it be equally as bioavailible? Any links referencing some research on the answer? Also curious Pike if you've got any research to back your answers 'cause I'm interested for sure.
check into the research that was done for "
ZYDIS" selegiline, which, iirc, is the sublingual brand currently on the market. imho, sublingual would be a nice idea if your intent on using selegiline was as an antidepressant. from an anti-aging stantpoint, however, i think oral has more to offer. plus, like i said before, i really don't like that dropper. oh yeah, and liquid selegiline tastes like rotten ass.
if the liquid citrate form does actually carry the purported 99.whatever% bioavailability that it claims to have, then i don't know why they bother telling you to administer it sublingually because oral would be just as effective. i mean, aside from the spike-crash effect you'd get in blood levels from about ANY sublingual administration, wouldn't that like... chop the half-life into little bits?
however, in terms of
citrate form... good luck finding any research. there is
none.Johann ==> i couldn't really say for sure what's causing your problems. i suppose the sure-fire thing you could do is stop both for now, because i think it's safe to assume that your klutzy side-effect is probably from ONE of those two. from what i've been reading, it looks like selegiline puts a lot of other people to sleep when they first try it (same problems with exhaustion). i'd never actually heard of the klutz effect you're talking about. i mean, it could be the LDN, but i have no idea. quick google check yields that
both list nausea/dizziness under side effects, so, maybe you just didn't luck out and they're both making you a bit klutzy???
protoject - actually i've been taking memantine&selegiline both for their individual effects, and their complementary effects.
SELEGILINE - I started taking selegiline after i found
THIS study showing selegiline had a CAE effect (which, afaik, is the only CAE on the consumer market) and
THIS study that tested what is arguably one of the most contraindicated combination of drugs ever, but remarkably, selegiline significantly reduced the amphetamine-based cardio side effects. I think i was sold after that. now, granted that BPAP and PPAP (the research CAEs), which i guess were based off of selegiline's CAE mech, are supposed to be
1000 times stronger to the point where they actually have amphetamine-like stimulant qualities (wiki), i'm still very satisfied from the minute CAE effect that i get. looking into the mechanism of action for CAEs, i'd like to think that THOSE are the true stimulants of the future.
i tried to write a quick joe-schmo explanation of CAEs, but the wiki on BPAP does it better:
BPAP.
MEMANTINE - i started taking memantine after i found out "low affinity" was a cooky way to say that it doesn't interfere with normal glutamate signalling. after that, i wasn't too worried about trying. before, i was pretty damn interested, but i thought the nmda-antagonism would block LTP formation; shows what i know. also, even though olney's lesions have never been discovered in humans (i guess it's a species specific thing), i haven't found any info on memantine even inducing them in animals when used in the low concentrations that humans use. nmda-antags enhance dopaminergic compounds, so it would sure as hell compliment my selegiline, prevent a large portion of the tolerance you get from them, and according to
this (+ a couple other studies) memantine will give you a nice neurogenesis slap to the face! it seems to do the same for bdnf (or maybe the bdnf is the neurogenesis effect? haven't read enough about bdnf) as well.
another reason i got into memantine was suggested in that article someone posted up. in theory, perhaps the blocking of low-level glutamate excitotoxicity over a very long period of time could offer some major anti-aging benefits in the cognition dept.
edit: it just occurred to me that my sele+mem combo might be edging a bit too much on the anticholinergic side.
Edited by Pike, 13 November 2009 - 05:58 PM.