Centrophenoxine may be effective at reducing lipofuscin volumes in cells. This means it's a substance that could have huge anti-aging benefits. Alpha GPC does not have these properties. Centrophenoxine also enhances neuronal glucose and oxygen uptake, while increasing carbon dioxide production, all signs of increased brain ATP production. Centrophenoxine also increases neuronal RNA and protein production.
It also seems to be highly effective as an ACh booster in animal studies:
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: Neuropharmacology. 1982 Apr;21(4):349-54.
Increases in choline levels in rat brain elicited by meclofenoxate (centrophenoxine).
Wood PL, Peloquin A.
Meclofenoxate, the p-cholorophenoxyacetic acid ester of deanol, was found to dramatically elevate choline (Ch) levels in the rat CNS. In the hippocampus, this elevation in choline was accompanied by a new elevated steady state level in acetylcholine (ACh). No such coupling was observed in the striatum or parietal cortex. Deanol also elevated choline levels in the CNS but was about half as potent as meclofenoxate; p-chlorophenoxyacetic acid was inactive in this respect. Lesions of striatal neurons with kainic acid and of hippocampal cholinergic nerve endings with surgical section of the fimbria indicated that the changes in choline levels were mainly extraneuronal. In spite of the changes in choline and ACh levels, no consistant alterations in ACh turnover were measured. In summary, meclofenoxate induced dramatic alterations in CNS choline metabolism and may, therefore, be a useful therapeutic tool for potentiating depressed cholinergic neurons.
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Acta Physiol Pharmacol Bulg. 1979;5(3):59-66. Related Articles, Links
Effect of centrophenoxine on acetylcholine release in perfused cerebral ventricles of cats under dynamic electrophysiological control.
Georgiev V, Chavdarov D, Petkov V, Kirilov B.
The effects of centrophenoxine on the release of acetylcholine and on the changes in the bioelectrical activity are determined in experiments on non-anaesthesized cats subjected to perfusion of the anterior horn of the lateral cerebral ventricle and simultaneous recording of the bioelectrical activity of cortical and subcortical structures. Centrophenoxine is tested in doses of 25, 50 and 100 mg/kg intravenously. Most characteristic changes are found to occur after the dose of 50 mg/kg, when centrophenoxine markedly increases the amount of the released acetylcholine and changes the bioelectrical activity (synchronous changes in the cortex and hypothalamus). The parallelism between the increase release of acetylcholine and the bioelectrical changes continued until the time of the peak effect of centrophenoxine (45 min), followed by dissociation between them (the level of the released acetylcholine gradually approached the initial level, while the changed bioelectrical activity persisted for a longer time.
Edited by hamishm00, 24 September 2009 - 12:31 PM.
