6 replies to this topic

[brain]

so i've been on the liquid selegiline for about a week now. for the first couple of days (despite knowing that this was a drug which can take weeks to kick in) i did feel and increase in calmness, but not in focus. more just that i felt content in whatever activity i chose to do. i took 10 mg sublingually the first day, and 5 mg for 4 days afterwards. i'm now taking 3. considering the high dosage that i'm taking and also considering sublingual vs. oral metabolism (supposedly sublingual is over 5x more bioavailable than oral), this might actually be more than enough to have already triggered nearly full drug activity/mao-b inhibition. i'm also not positive about this by any means, as many people have noted that the drug does not begin to work for several weeks.

the first day i combined selegiline with 750 mg dl-phenylalaine and a 10 mg nicotine patch and about two cups of coffee and my normal dose of 4,000 mg piracetam + alpha-GPC and became much too overstimulated and burnt out pretty badly later in the day. not as bad as an amphetamine crash, but close.

i've lowered my nicotine patch dosage to 7 mg (i recently quit, btw, so this isn't very high for me) cut the caffeine and am now considering dropping everything other than the deprenyl to consider it's effects in isolation. i've noticed today that i felt more hyperactive than usual, contrary to the initial sense of calm. this may have been because about half of my daily calories today have come from miniature halloween chocolates which aside from sugar have plenty of PEA in them.

mostly, i'm wondering if i might expect any changes in how this drug feels, which so far is very mild other than seeming to potentiate other substances with effect DA, and i'm also curious what other adhd user's effects with deprenyl are, what dose you used, whether it was liquid or tablet form, how long you used it, etc. i will also keep updating on my experience with the deprenyl liquid.

[OneScrewLoose]

I took it for ADHD for a while and it helped, but not enough for me to keep taking it.

[Johann]

I took it for ADHD for a while and it helped, but not enough for me to keep taking it.

I am always talking about buying some selegiline but I can't get much feedback here. I want to know if it is worth the money and the time. I also would like to know how it might interact with low dose naltrexone. I don't take either yet but would like to try them. I read somewhere on here that the LDN affect the dopamine as well so could that be a good thing? Or too much of a good thing?
I wish there were more funkodysesy and Irish MD posters on here. They seem to know what they are talking about.

[Johann]

Let me add this: While on wellbutrin I was on a safe roll. I was driving along listening to the tunes and hearing
every musical instrument. I wasn't the slightest bit pissed at the people that would normally aggravate me while they jaywalk in front of my car... everything was great and I was focused! Except that I knew my nicotinic receptors were getting raped and that eventually my recall would be worthless.

So here is my overly simplistic reasoning: I take the selegiline and get the wellbeing and the focus and the drop in transient fibro pains YET I don't get the nasty abuse of the nicotinic receptors.. eh? eh? Whatcha think of that hypothesis?

[FunkOdyssey]

Let me add this: While on wellbutrin I was on a safe roll. I was driving along listening to the tunes and hearing
every musical instrument. I wasn't the slightest bit pissed at the people that would normally aggravate me while they jaywalk in front of my car... everything was great and I was focused! Except that I knew my nicotinic receptors were getting raped and that eventually my recall would be worthless.

So here is my overly simplistic reasoning: I take the selegiline and get the wellbeing and the focus and the drop in transient fibro pains YET I don't get the nasty abuse of the nicotinic receptors.. eh? eh? Whatcha think of that hypothesis?

I don't think this will work out, since the pharmacology of wellbutrin is drastically different from selegiline. Selegiline may either be helpful or detrimental for well-being depending on the dose and your neurochemistry, may help focus somewhat, but will likely do nothing for fibro pains.

If you are curious about deprenyl just try it, its not expensive and individual responses are so varied its hard to predict whether it will help you. Although one thing I find sort of telling is that very few people that have tried it have remained on it indefinitely.

[Pike]

i've recently just finished the second month of a consistent Memantine + Selegiline combo and can say that the combination has been very effective. I never got to the 3 month marker w/selegiline before - the point where it's supposed to reach max efficacy, but 1 more month and I will be able to report in!

I will say, however, that when you first start taking selegiline it's going to knock you on your ass, much in the same way dopamine agonists do.

[mk-ultra]

so i've been on the liquid selegiline for about a week now. for the first couple of days (despite knowing that this was a drug which can take weeks to kick in) i did feel and increase in calmness, but not in focus. more just that i felt content in whatever activity i chose to do. i took 10 mg sublingually the first day, and 5 mg for 4 days afterwards. i'm now taking 3. considering the high dosage that i'm taking and also considering sublingual vs. oral metabolism (supposedly sublingual is over 5x more bioavailable than oral), this might actually be more than enough to have already triggered nearly full drug activity/mao-b inhibition. i'm also not positive about this by any means, as many people have noted that the drug does not begin to work for several weeks.

the first day i combined selegiline with 750 mg dl-phenylalaine and a 10 mg nicotine patch and about two cups of coffee and my normal dose of 4,000 mg piracetam + alpha-GPC and became much too overstimulated and burnt out pretty badly later in the day. not as bad as an amphetamine crash, but close.

i've lowered my nicotine patch dosage to 7 mg (i recently quit, btw, so this isn't very high for me) cut the caffeine and am now considering dropping everything other than the deprenyl to consider it's effects in isolation. i've noticed today that i felt more hyperactive than usual, contrary to the initial sense of calm. this may have been because about half of my daily calories today have come from miniature halloween chocolates which aside from sugar have plenty of PEA in them.

mostly, i'm wondering if i might expect any changes in how this drug feels, which so far is very mild other than seeming to potentiate other substances with effect DA, and i'm also curious what other adhd user's effects with deprenyl are, what dose you used, whether it was liquid or tablet form, how long you used it, etc. i will also keep updating on my experience with the deprenyl liquid.

Be careful with combos while on selegiline. You could end up delusional like that guy on bluelight who claims he can read minds while on maoi-b + pea, or worse. There are plenty of tales of ppl who innocently mixed maois with other substances that landed them in ER.
Selegiline potentiates stimulants.. Thread carefully.