The percentages over just two decades are HUGE.
A Population-Level Decline in Serum Testosterone Levels in American Men
Thomas G. Travison, Andre B. Araujo, Amy B. O'Donnell, Varant Kupelian and John B. McKinlay New England Research Institutes, Watertown, Massachusetts 02472
Address all correspondence and requests for reprints to: Thomas G. Travison, Ph.D., New England Research Institutes, 9 Galen Street, Watertown, Massachusetts 02472. E-mail: ttravison@neriscience.com.
Context: Age-specific estimates of mean testosterone (T) concentrations appear to vary by year of observation and by birth cohort, and estimates of longitudinal declines in T typically outstrip cross-sectional decreases. These observations motivate a hypothesis of a population-level decrease in T over calendar time, independent of chronological aging.
Objective: The goal of this study was to establish the magnitude of population-level changes in serum T concentrations and the degree to which they are explained by secular changes in relative weight and other factors.
Design: We describe a prospective cohort study of health and endocrine functioning in randomly selected men of age 45–79 yr. We provide three data collection waves: baseline (T1: 1987–1999) and two follow-ups (T2: 1995–1997, T3: 2002–2004).
Setting: This was an observational study of randomly selected men residing in greater Boston, Massachusetts.
Participants: Data obtained from 1374, 906, and 489 men at T1, T2, and T3, respectively, totaling 2769 observations taken on 1532 men.
Main Outcome Measures: The main outcome measures were serum total T and calculated bioavailable T.
Results: We observe a substantial age-independent decline in T that does not appear to be attributable to observed changes in explanatory factors, including health and lifestyle characteristics such as smoking and obesity. The estimated population-level declines are greater in magnitude than the cross-sectional declines in T typically associated with age.
Conclusions: These results indicate that recent years have seen a substantial, and as yet unrecognized, age-independent population-level decrease in T in American men, potentially attributable to birth cohort differences or to health or environmental effects not captured in observed data.
From http://www.ourstolen...avisonetal.html
In one of the largest study of its kind, Travison et al. report a population-wide decline in Massachusetts's men’s testosterone levels during the last 20 years that is not related to normal aging or to health and lifestyle factors known to influence testosterone levels.
They found that testosterone concentrations dropped about 1.2% per year, or about 17% overall, from 1987 to 2004. The downward trend was seen in both the population and in individuals over time.
The decline is consistent with other long-term trends in male reproductive health, including decreases in sperm quality and increases in testicular cancer, hypospadias and cryptorchidism.
The strongest association was observed in same-aged men from different sampling years. For example, a 65-year-old in 2002 had lower testosterone levels than a 65-year-old in 1987.
Lower concentrations of testosterone can increase a man’s risk for age-related diseases, depression and infertility.
Also, the younger and older men in the study experienced similar hormone declines that dropped faster than would be predicted by normal aging.
Context: In men, the hormone testosterone guides behavior and reproduction. It controls growth and development of sex organs and other typically male characteristics, such as facial hair and a deep voice.
Normally, levels fluctuate from conception through puberty then level out during adulthood before declining as men age. Some chronic health problems typically seen in older adults, such as diabetes, depression and obesity, are associated with lower testosterone levels.
Recent studies have that found environmental impacts on testosterone levels. For example, testosterone levels were lower in US Air Force veterans exposed to dioxins while spraying Agent Orange during the Vietnam War, as well as in men exposed to phthalates at work.
What did they do?
Travison et al. used blood hormone data and personal information collected from men living in Boston, MA, as part of the Massachusetts Male Aging Study (MMAS). The MMAS examined men’s health and endocrine function. Data were gathered during three home visits from 1987-89 (T1), 1995-97 (T2), and 2002-04 (T3). Total testosterone (TT) and serum sex hormone-binding globulin were measured in the blood and available testosterone (BT) was calculated. The men self-reported such things as basic demographics, health status, and smoking and alcohol use.
In this study, Travison et al. analyzed data from 1,532 men (1,383, 955, and 568, respectively, from T1, T2 and T3) that met age and birth year requirements. Participants ranged from 45 to 79 years old and were born between 1916 and 1945. The researchers excluded high and low T levels, missing data, and unidentified prostate cancer treatment. Within the sample, they calculated and compared three separate but related associations among concentration, age, and time. They looked at changes in testosterone concentrations in the group of men at different years and ages associated with T1, T2, and T3; testosterone declines in individual men as they aged during the study; and testosterone concentrations of men of the same age but in different years (age-matched).
What did they find?
Travison et al. found strong evidence of a decline of more than 1% per year in men’s blood testosterone levels during the last two decades. The graph to the right shows average levels for each for men of different ages in each of the three measurement periods (T1-T3).
Dotted lines are 95% confidence bands. Adapted from Travison et al.
The crucial comparison to make is from one cohort to the next, comparing men of the same age. For example, 60 yr old men during the first measurement period (red line, 1987-1989) had total testosterone levels over 500 ng/dL. Men aged 60 yrs old in the third cohort (blue line, measured 2002-2004) had TT below 450 ng/dL. There is no overlap between the confidence bands of T1 vs T3: T3 (measured 2002-2004) is always lower than T1.
The trend holds regardless of the men’s age. Similar declines over the 17 years were seen in all ages of men in the study.
Travison et al. note that the decline within the cohorts related to age is less than the decrease observed across cohorts. For example, men aged 70 in T1 had TT only 6% less than men aged 45 in the same cohort. But 60 yr old men in T3 had TT concentration approximately 13% lower than men the same age in T1.
To illustrate this point another way, Travison et al. compared the average decline of testosterone levels in T1 vs T2 as a function of age, and then contrast that with differences in testosterone between men of the same age in T1 vs T2. Note that T1 and T2 were only separated by 9 years. The average declines in T1 and T2 per decade of life were 17 and 20 ng/mL, respectively. But 65 yr old men in T2 had total testosterone levels 50 ng/mL lower than those in T1, even though the samples were separated by less than a decade.
Travison et al. then estimated the decline over time, from the first cohort to the third, for men of the same age (what they called the age-matched decline). They found that testosterone declined by 1.2% per year (95% CI 1.0% to 1.4%).
Bioavailable testosterone (BT) also showed similar declines over time. The strongest associations again held for age-matched trends with declines of 1.3% per year (95% CI 1.7% - 1.1%).
None of the health and lifestyle factors examined were associated with either age-matched declines in either TT or BT: The age-matched declines remained essentially the same after controlling for chronic illness, general health, medications, smoking, body mass index, employment, marital status, and other indicators.
Finally, the trends held when analyzing the data in a number of different ways, including by interview date, study cohort, restricting to men of certain ages or birth cohorts, and considering incomplete versus complete data.
What does it mean?
Travison et al. find that testosterone levels declined in Massachusetts men by approximately 1.2% per year from the late 1980s through 2004, controlling for the age of the men and other possible confounding variables.
This study is important because of its large sample size and long duration. Few studies have looked directly at testosterone levels over time.
The results are surprisingly consistent with another set of long-term human epidemiology studies. Those studies also show a long-term decline in male reproductive functions, such as <a href="http://www.ourstolen....htm">decreased sperm health and increased infertility, which are highly associated with or controlled by testosterone and other androgen hormones. The rate of decline reported in this study is roughly comparable to the rate of decline of sperm count reported first by Carlson et al. in 1992 and then reanalyzed by Swan et al.in 2000.
In commentary accompanying Travison et al.'s study in the Journal of Clinical Endocrinology and Metabolism, Dr. Shalender Bhasin (Boston Medical Center) writes: The data in this study are "important because they provide independent support for the concerns raised earlier about the reproductive health of men." ... "it would be unwise to dismiss these reports as mere statistical aberrations because of the potential threat these trends-- if confirmed-- pose to the survival of the human race and other living residents of our planet."
Edit: fixed broken link
Edited by niner, 24 October 2009 - 04:40 AM.
