original thread
my original suggestion was standard riboflavin... i was unable to find any data on the pharmacodynamics of supplemental riboflavin-5′-phosphate
Posted 05 November 2009 - 06:27 PM
Posted 05 November 2009 - 08:16 PM
original thread
my original suggestion was standard riboflavin... i was unable to find any data on the pharmacodynamics of supplemental riboflavin-5′-phosphate
Posted 08 November 2009 - 02:21 AM
Absorption, metabolism, and excretion of riboflavin-5-phosphate in man
William J. Jusko, Gerhard Levy
Biopharmaceutics Laboratory, Department of Pharmaceutics, School of Pharmacy, State University of New York at Buffalo 14214
Funded by:
Institute of General Medical Sciences, U. S. Public Health Service, Bethesda, Md.; Grant Number: R01-AM08753-03
Abstract
Evidence is presented which indicates that riboflavin-5-phosphate (FMN) is absorbed from the gastrointestinal tract of man by specialized transport rather than by passive diffusion. Oral administration of the vitamin after a meal results in more extensive absorption which appears to be primarily due to a decrease in intestinal transit rate resulting in longer retention of FMN at absorption sites in the small intestine. Both FMN and riboflavin are excreted in the urine primarily, if not solely, as free riboflavin. The urinary recovery of riboflavin is the same when equimolar amounts of either form of the vitamin are administered orally in solution. The time course of urinary excretion of riboflavin after administration of high doses of FMN, together with data available in the literature, suggest that the vitamin is subject to enterohepatic cycling.
Edited by ajnast4r, 08 November 2009 - 02:25 AM.
Posted 08 November 2009 - 04:14 AM
Sounds good.after a bit of research i think it may be best to use 1mg standard riboflavin & 1 mg riboflavin-5-phosphate... riboflavin occurs in food in both forms and it appears there are transport mechanisms for both forms as well.
digestion, absorption, transport & storage of riboflavin
http://www.ncbi.nlm..../pubmed/6030496Absorption, metabolism, and excretion of riboflavin-5-phosphate in man
William J. Jusko, Gerhard Levy
Biopharmaceutics Laboratory, Department of Pharmaceutics, School of Pharmacy, State University of New York at Buffalo 14214
Funded by:
Institute of General Medical Sciences, U. S. Public Health Service, Bethesda, Md.; Grant Number: R01-AM08753-03
Abstract
Evidence is presented which indicates that riboflavin-5-phosphate (FMN) is absorbed from the gastrointestinal tract of man by specialized transport rather than by passive diffusion. Oral administration of the vitamin after a meal results in more extensive absorption which appears to be primarily due to a decrease in intestinal transit rate resulting in longer retention of FMN at absorption sites in the small intestine. Both FMN and riboflavin are excreted in the urine primarily, if not solely, as free riboflavin. The urinary recovery of riboflavin is the same when equimolar amounts of either form of the vitamin are administered orally in solution. The time course of urinary excretion of riboflavin after administration of high doses of FMN, together with data available in the literature, suggest that the vitamin is subject to enterohepatic cycling.
Posted 08 November 2009 - 04:32 AM
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