Galantamine and Hyperzine A

#1

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Posted 17 April 2004 - 11:07 PM

These are both classified as acetylcholinesterase inhibitors, however Galantamine seems to have multiple functions in the brain. What I'd like to know is what differentiates the two supplements? Should I avoid stacking them together to prevent cholineristic(sp?) side effects?

#2 axiombiological

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Posted 18 April 2004 - 04:04 AM

The studies I have seen demonstrate that Huperzine A also is an NMDA antagonist, but I don't know if the concentrations used would be applicable to real world use. Galantamine, while an acetylcholinesterase inhibitor like Huperzine, has a much lower affinity than huperzine and a much higher cost. Galantamine is used in 20-30mg/day doses, whereas Huperzine is in the 50-200mcg range.

Taking both together probably would be risking cholinergic side effects, unless taken in lower doses. Galantamine seems to be eliminated slower than huperzine, also.

#3

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Posted 18 April 2004 - 05:11 AM

Alright then, I hadn't planned on using Galantamine in my nootropic stack, but seeing as how Hyperzine A is so potent (and cheap) I will stick to using it, as I had planned from the beginning.

One quick question while we're on the subject, why is Hyperzine A not used in place of Ritalin since both have the same main function in the body and Hyperzine A seems to have less side effects, wouldn't it be a better drug for ADHD sufferers?

#4 axiombiological

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Posted 18 April 2004 - 06:58 AM

cosmos: One quick question while we're on the subject, why is Hyperzine A not used in place of Ritalin since both have the same main function in the body and Hyperzine A seems to have less side effects, wouldn't it be a better drug for ADHD sufferers?

I don't think that Huperzine is being prescribed in the US for anything. It is being sold only as a supplement/herbal extract.

#5

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Posted 18 April 2004 - 07:30 AM

I might be wrong about Ritalin being an acetylcholinesterase inhibitor, but in general in Hyperzine A seems like a good alternative to other prescription acetylcholinesterase inhibitors.

Anyway thanks for filling me in on Galantamine. I may take Hyperzine A spread out two or 3 times during a day to maintain it's effects in my body.

#6 chomsky

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Posted 18 April 2004 - 03:34 PM

Ritalin is not an acetylcholine esterase inhibitor. It is a CNS stimulant analogous to the various forms of amphetamine, meaning it targets the catecholamines (dopamine, epinephrine, norepinephrine).

Also, the difference with Huperzine is that Galantamine modulates nicotinic acetylcholine receptors while dually acting as an acetylcholine esterase inhibitor.

#7

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Posted 18 April 2004 - 05:45 PM

I saw the mistake after the fact.

Galantamine seems interesting if it does indeed serve that dual purpose but Hyperzine A remains quite a bit cheaper. If "modulation of nicotinic acetylcholine receptors" is something I would want or is in some way advantagious to me then I will consider using Galantamine in the future. Until then I'll read up further and see what results from people have from using Galantamine and whether they are scientifically backed.

#8 axiombiological

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Posted 30 April 2004 - 06:46 PM

An interesting natural product is desoxypeganine, from the Peganum harmala plant. This compound is an anti-cholinesterase (reversible) and MAOI. It has been researched in Russia for use in Alzheimer's.

#9 LifeMirage

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Posted 02 May 2004 - 03:39 AM

Very interesting but very few studies I can find on it. I'll try it when I get a chance.

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