8 replies to this topic

[youandme]

Its a huge headline...and if true could turn the current treatments for MS on their heads!
The hypothesis is that MS is a vascular condition..not an Autoimmune condition..... that can be fixed by unblocking arteries.
Iron Deposits are indicated as the initial cause....read on !

As ever time will tell !!

http://www.theglobea...article1372414/




btw please can mods fix up the obvious speeling mistake in the title ..thx

Edited by youandme, 21 November 2009 - 10:08 AM.

[AgeVivo]

It does seem like great news! Are there publications on the subject?

Perhaps in the next years it will become natural to go to his doctor to check for blocked brain arteries, and have them unblocked with a catheter. The technique has been present for long, it is just a matter of discovering that it applies to a much wider range of diseases than we earlier thought. Alzheimer's disease is thought to have a vascular origin too, at least in some cases.

Of course it takes time in humans, to test, accept and recommand procedures. When I first heard of Aubrey de Grey and of the MPrize, I had vaguely understood that one project was to clean mice vascularly, to see if they would live longer. Is it something feasible??

[youandme]

If this pans out..perhaps other neurological diseases would have a vascular/BBB implication.

Edited by youandme, 21 November 2009 - 12:51 PM.

[Blue]

MS incidence peaks at age 18-35 so it is not an old age disease. Therefore less likely that the cause or treatment is relevant to neurological diseases associated with aging. Also makes it unlikely that cumulative damage from iron is the cause. There is also the strong association with increasing incidence with less sunlight by living away from the equator and what looks like a strong effect on the disease by vitamin d supplementation. Maybe lack of vitamin d, especially in children, causes vascular malformations?

Edited by Blue, 21 November 2009 - 02:23 PM.

[youandme]

A bit more information

http://www.scienceda...91023163358.htm some more information includes an email address for info about the upcoming studies in US/Canada


Video Documentary about the treatment..(I like pictures..especially moving ones !)

http://www.ctv.ca/se...91121?s_name=W5

[youandme]

It does seem like great news! Are there publications on the subject?

"Chronic cerebrospinal venous insufficiency in patients with multiple sclerosis"
http://jnnp.bmj.com/.../4/392.abstract

I believe a further study is about to be published

Edited by youandme, 22 November 2009 - 01:41 AM.

[Mind]

From the popular write-up, it is hard to tell what the scientific basis for the iron theory is. It seems what we can take away from this is that clearing clogged arteries can help with neurological problems. I wonder if the neurological problems associated with clog arteries to the brain (the cases described in the article) are being misclassified as MS, or that poor blood flow leads to MS-like symptoms.

In any case, if it is successful in relieving symptoms, that is what matters most to those who suffer.

[niner]

From the popular write-up, it is hard to tell what the scientific basis for the iron theory is. It seems what we can take away from this is that clearing clogged arteries can help with neurological problems. I wonder if the neurological problems associated with clog arteries to the brain (the cases described in the article) are being misclassified as MS, or that poor blood flow leads to MS-like symptoms.

In any case, if it is successful in relieving symptoms, that is what matters most to those who suffer.

Yeah, I didn't get the iron theory either. Zamboni ascribed it to venous strictures of unknown origin. Someone was channeling Bill Sardi? Well, it was brilliant work and it looks like a huge leap forward in MS.

Edit: OK, here's something from the sciencedaily link above:

Advanced magnetic resonance imaging scanning (MRI) of the MS study patients conducted at the BNAC also identified distinct areas of iron deposits in the brain, and showed that those deposits may be associated with the location of MS lesions and sites of impaired drainage. The scans also revealed increased brain atrophy and changes in the flow of cerebrospinal fluid in the MS patients.

I don't know if the venous insufficiency was caused by iron, or if it causes the iron to build up, and has an entirely different etiology. Sounds like there is a lot of work going on with this now, and we should soon have a good picture of it.

Edited by niner, 23 November 2009 - 08:29 PM.

[brokenportal]

When I read this in the current headlines section on the front page, at first I thought it said, "Some US symptoms may be caused by arterial blockage." and I thought, youve got to be kidding me, they think a ton more US people are getting the swine flu because they are fat?

Anyways, I like how the front page is going. I look through the new headlines every day now. Cyberbrain and Victor, make sure that you indicate if you were working with the front page for the month so we can mark your name with a star in the volunteer prize system.