7 replies to this topic

[OneScrewLoose]

Bad to take long-term, right?

[dupez]

thats the general consensus that I'm aware of. I use it on an as-need basis (when a test date is approaching). I usually do piracetam+alpha gpc in the AM and hup a around dinner time. don't take them at the same time.

[pycnogenol]

For what its worth, LEF has this to say about Hup-A:

"While it is safe to boost acetylcholine levels by inhibiting acetylcholinesterase periodically, chronic use of Huperzine A could cause over-suppression of acetylcholinesterase and subsequent acetylcholine overload with unknown consequences. Remember, you can take huge amounts of acetylcholine precursors such as choline without fear of acetylcholine overload because you have acetylcholinesterase to degrade excess acetylcholine. If you block the body’s natural regulator of acetylcholine (that regulator being acetylcholinesterease), you may have a problem. We do not recommend that people take Huperzine A more than twice a week, much less promote it for daily use like other companies do."

[Imagination]

I didn't notice much from it, alot of people say cycle it, but it doesn't say that on the bottle usually so I assume it's ok.

[Declmem]

Not sure how much benefit you'd get from 2 times a week. It consistently takes me a few days of daily use to start getting benefits from it.

I haven't heard that it is too bad, just not as well researched as galantamine. That said, I prefer CDP Choline.

[medicineman]

it also blocks NMDA receptors, making long term memory consolidation more difficult in theory. It produces acute results, basically memory on a lease from my personal experience......

I take it once or twice a week not for its cholinesterase blocking effects, but for its effects via brain trophic factors.

[Declmem]

it also blocks NMDA receptors, making long term memory consolidation more difficult in theory. It produces acute results, basically memory on a lease from my personal experience......

I take it once or twice a week not for its cholinesterase blocking effects, but for its effects via brain trophic factors.

Ah, that's interesting. Does galantamine suffer from the same problem?

Are there any NMDA enhancers?

[medicineman]

it also blocks NMDA receptors, making long term memory consolidation more difficult in theory. It produces acute results, basically memory on a lease from my personal experience......

I take it once or twice a week not for its cholinesterase blocking effects, but for its effects via brain trophic factors.

Ah, that's interesting. Does galantamine suffer from the same problem?

Are there any NMDA enhancers?

Piracetam primes NMDA receptors, making them more effective. You don't want to juice up NMDA too much, since neurotoxicity is also mediated by overworked NMDA and AMPA receptors....