18 replies to this topic

[rashlan]

Hi i'd like to apologise for for the poor spelling and grammar in advance. About ten years ago my mother started having short term memory problems. At the time i didnt really think much of it but was deluded enough to think that it was so sort of immune response to her 18 amalgam fillings. I suggested that maybe she should have them replaced and over the next five years she did. About five years ago her memory was still in decline and she had a new symptom of occasionally slurring her words, she started taking some fish oil capsules and booked a doctors appointment. She was referred to a neurologist who asked her a few questions to test her memory and ordered an MRI. Her memory test (if it can be called that when it consisted asking her to remember three words) didn't go very well as she couldn't remember a single word but was advised by the doctor that it wasn't really a problem as shes probably just stressed. When the MRI came back it showed high activity in the left hippocampus. She was told that this wasn't a problem, that she was fine and on hearing this she stopped talking about her memory problems and insisted that there wasnt anything wrong with her. Two years ago her memory was still deteriorating but at what seemed a slower pace yet her speech problem was much worse with her slurring in nearly every sentence. I tried to get her to book another appointment with a doctor but she has refused to insisting she is fine. after a few months i gave in and just asked if she could possibly start taking citicoline, she agreed and over about two months there was a dramatic improvement in her memory and she completely stopped slurring. I was over the moon at this yet had a nagging feeling that i was just covering up her symptoms of an underlying disease. About twelve months ago she started slurring her words again, then out of the blue three months ago it changed to her not being able to speak fluently and would get stuck on words in every sentence like her brain couldn't cope with the pace needed for speech.
I dont know what to do at this point and cant Imagen living in a word without her to the point i feel suicidal. I realise that there isnt that much i can really do but any advice would be greatly appreciated.

[Elus]

Please take a look at the following. It may help your mother.


http://en.wikipedia..../Methylene_blue


TauRx Therapeutics has reported that methylene blue (methylthioninium chloride), under the tradename rember, may provide a way of halting or slowing the progression of Alzheimer's dementia.[28] However, the formulation used was different from that commonly available as a medicine and caution has been expressed about use of methylene blue as a treatment for Alzheimer's.[29] TauRx Therapeutics has suggested that the mechanism by which methylene blue might delay or reverse neurodegeneration in Alzheimer's disease is as an inhibitor of Tau protein aggregation. While methylene blue arguably has an effect on Tau aggregation, it also has an effect on mitochondrial function which is likely to play an important role. In vitro studies suggest that methylene blue might be an effective remedy for both Alzheimer's and Parkinson's disease by enhancing key mitochondrial biochemical pathways. It can disinhibit and increase complex IV, whose inhibition correlates with Alzheimer's disease.

Methylene blue might also delay senescence as one study has shown that it extended the lifespan of IMR90 fibroblasts by more than 20 population doublings.[30]

These findings are highly controversial, and a clear dosage response curve has not been found.

[rashlan]

Please take a look at the following. It may help your mother.


http://en.wikipedia..../Methylene_blue


TauRx Therapeutics has reported that methylene blue (methylthioninium chloride), under the tradename rember, may provide a way of halting or slowing the progression of Alzheimer's dementia.[28] However, the formulation used was different from that commonly available as a medicine and caution has been expressed about use of methylene blue as a treatment for Alzheimer's.[29] TauRx Therapeutics has suggested that the mechanism by which methylene blue might delay or reverse neurodegeneration in Alzheimer's disease is as an inhibitor of Tau protein aggregation. While methylene blue arguably has an effect on Tau aggregation, it also has an effect on mitochondrial function which is likely to play an important role. In vitro studies suggest that methylene blue might be an effective remedy for both Alzheimer's and Parkinson's disease by enhancing key mitochondrial biochemical pathways. It can disinhibit and increase complex IV, whose inhibition correlates with Alzheimer's disease.

Methylene blue might also delay senescence as one study has shown that it extended the lifespan of IMR90 fibroblasts by more than 20 population doublings.[30]

These findings are highly controversial, and a clear dosage response curve has not been found.

Thanks i just dont know how i could get her on a trial for something like that when she now refuses to acknowledge that there is a problem.

Edited by rashlan, 11 December 2009 - 12:02 AM.

[garlicknots]

Hmm,

I don't understand, is she willing to take any pills? There is a UCLA researched curcumin product marketed by Longvida that has pretty good penetration into the brain. They used it in a clinical trial for Alzheimers. I don't the results have been released yet, but here is some information on it:

Optimized Curcumin Chart

and

More info, and some links.

It's 1:30 am here, but will get back to you later. PPP might be able to chime in the meantime.

[ppp]

Hmm,

I don't understand, is she willing to take any pills? There is a UCLA researched curcumin product marketed by Longvida that has pretty good penetration into the brain. They used it in a clinical trial for Alzheimers. I don't the results have been released yet, but here is some information on it:

Optimized Curcumin Chart

and

More info, and some links.

It's 1:30 am here, but will get back to you later. PPP might be able to chime in the meantime.

LongVida is being used in a number of trials and as you've mentioned shows pretty good bioavailability. The person to really ask though is Dr Sally Frautschy at the UCLA Alzheimer's Research Laboratory. There's some good information here: http://alzheimer.neu...u/Curcumin.html

[Jay]

Ketones from MCT oil, coconut oil or derived from full-on ketosis (very low-carb diet) may be very helpful.

[rashlan]

Hmm,

I don't understand, is she willing to take any pills? There is a UCLA researched curcumin product marketed by Longvida that has pretty good penetration into the brain. They used it in a clinical trial for Alzheimers. I don't the results have been released yet, but here is some information on it:

Optimized Curcumin Chart

and

More info, and some links.

It's 1:30 am here, but will get back to you later. PPP might be able to chime in the meantime.

Hi, yeah she will take tablets but not more than four. Is it available yet as i can't seem to find anywhere selling it?

[rashlan]

Ketones from MCT oil, coconut oil or derived from full-on ketosis (very low-carb diet) may be very helpful.

Thanks but unfortunately i'd never be able to talk her into anything like that.

[rwac]

Thanks i just dont know how i could get her on a trial for something like that when she now refuses to acknowledge that there is a problem.

You can get some Methylene Blue, dilute it yourself and give it to her in some water.
Is that something you're willing to do ?

Edited by rwac, 12 December 2009 - 03:47 PM.

[rashlan]

Thanks i just dont know how i could get her on a trial for something like that when she now refuses to acknowledge that there is a problem.

You can get some Methylene Blue, dilute it yourself and give it to her in some water.
Is that something you're willing to do ?

I thought that it had to be injected to increase plasma levels? She'd probably think i was trying kill her off with some antifreeze !

Edited by rashlan, 12 December 2009 - 05:59 PM.

[rwac]

I thought that it had to be injected to increase plasma levels? She'd probably think i was trying kill her off with some antifreeze !

You don't have to inject it. It's absorbed fine orally upto 60mg or so.
I'd say it's definitely worth a shot.

You can also get coconut oil gelcaps, if eating it is out of the question.

[nameless]

Hi, yeah she will take tablets but not more than four. Is it available yet as i can't seem to find anywhere selling it?

http://www.longvida.com/

You can buy it directly by emailing them.

[niner]

she will take tablets but not more than four.

Rashlan, from your description of your mum's condition, it sounds like she is pretty obviously affected. Is she unaware, or possibly depressed or in denial? It might be worth talking with her doctor yourself, and trying to get her more on board with treatment. I think there are probably a lot of things that could help her, but not if she isn't willing to take them.

[Sillewater]

My Grandpa's faculties have slowly been degrading and I want to give him some supplements that would be effective, this is what I have come up with:

Morning
LEF Super BIO-Curcumin (400mg)
Niacinamide (500mg)
Methylcobalamin (5mg)
ALCAR (500mg)
MCT
Methylene Blue (Kordon brand, 60mcg)
CDP-Choline

Evening
ALA (150mg)
Lithium Orotate (5mg)
Methylene Blue (Kordon brand, 60mcg)
Melatonin (3mg)
Piracetam

Are there any more suggestions? He's 80 years old but still in fairly good health and like the OP I can't not do nothing. How are the dosages?

Edited by Sillewater, 21 December 2009 - 11:32 AM.

[rwac]

What's his diet like ?

I'd suggest adding some Niacin and D3+K2 for arterial health. (Hope he's not on anti-clotting agents)
Also, some Magnesium for general inflammation.

Perhaps even some retinol.

As for MB, there may be different effects at around 60mcg and a few mg. (TauRX used 60mg!)
Not sure which one would be more beneficial for him. Play around with the dose ...

[Sillewater]

What's his diet like ?

I'd suggest adding some Niacin and D3+K2 for arterial health. (Hope he's not on anti-clotting agents)
Also, some Magnesium for general inflammation.

Perhaps even some retinol.

As for MB, there may be different effects at around 60mcg and a few mg. (TauRX used 60mg!)
Not sure which one would be more beneficial for him. Play around with the dose ...

He just came back from China so I'll have to help him with his diet too. I plan on removing wheat, sugar, and vegetable oils.

I will definitely have the basics covered for him such as niacin and D3/K2. Thanks for the help.

I thought TauRX use 60mcg?

[AgeVivo]

I'm not a medical doctor but:
- yes you can find curcumin in many supermarkets in the spices section. add a little of pepper and mix with oild. use it in salad or anywhere. it should not be dangerous at all. might not do anything neither
- you can find methylene blue in pharmacies or for fish (good quality grade). if dilluted like the blue bootles pictures here: http://www.imminst.o...o...3947&st=140 it should not be dangerous at all but a lot should be drank before it could perhaps do something
- of course, since her symptoms are unexpected make sure she isn't lacking something: that she takes fruits and veggetables, sardine and rape oil. And see if a doctor can find what she has.
good luck

[rwac]

I thought TauRX use 60mcg?

There was some doubt about that, but I remember looking at the trials, and it said 60mg, so I am inclined to believe that.
Unfortunately, I can't find the link right now.

MB has different effects at larger doses. It's an anti-malarial, and it's also used against urinary infections...

[AgeVivo]

I thought TauRX use 60mcg?

indeed, here is a precise thread about it, with long posts by Michael: http://www.mfoundati...read.php?p=4119
at such high doses methylene blue gives diarrhoea so they encapsulate it. the product is called rember