Hmm,
The new compound, mitaplatin, combines cisplatin with another compound, dichloroacetate (DCA), which can alter the properties of mitochondria selectively in cancer cells. Cancer cells switch their mitochondrial properties to change the way they metabolize glucose compared to normal cells, and DCA specifically targets the altered mitochondria, leaving normal cells intact.
DCA + Cisplatin - Science Daily
Individually both of them have shown ability to cross the BBB, not sure if the combination can. DCA is being used somewhat in Canada, cisplatin is pretty standard for some cancers in the USA. As a monotherapy I don't really think DCA is that successful (many of the semi successful results included significant dietary changes, etc.) but used as an adjuvtant maybe it could be helpful. There is a brain tumor trial going on somewhere for temodar + DCA, wondering how that pans out.
fahd.