2 replies to this topic

[Chaos Theory]

I have been using selegiline in low doses for nearly 9 months now. For around the first 7 months the selegiline always had the same effect on me. Mostly increased drive and mood, as well as enhanced concentration. For that same period of time I had always used a magnesium supplement containing bioperine, as well as 500mg of resveratrol every morning. Since I stopped using both of those I have noticed that the effects of the selegiline have changed. I still feel it, but the effects seem blunted somehow.

Both bioperine and resveratrol are reported to have an effect on liver enzymes. Bioperine more notably but I used it far less consistently than the resveratrol.

[pycnogenol]

No experience with selegiline but I used to take bioperine with resveratrol and it shot up my liver enzymes so
I dropped the bioperine but still take resveratrol. I've since had my liver enzymes rechecked and they are now
back in the normal range. Needless to say, I probably won't be taking bioperine anytime soon. Selegiline intrigues
me but I have yet to pull the trigger and try it out. Maybe one day.

Edited by pycnogenol, 02 January 2010 - 11:56 PM.

[Chaos Theory]

Now that I'm looking into this more I'm wondering if it was a synergy between the effects of resveratrol and selegiline. Resveratrol has MAOI action by itself. There's a thread over on Dr.Bob from a few years ago where the person implied that resveratrol alone could make someone manic.