Would Piracetam and Glutamine be considered synergistic with one another?
We focus on Choline supplementation, but don't take Glutamine into much consideration at all. Why is that?
Edited by Viscid, 13 January 2010 - 02:04 AM.
Posted 13 January 2010 - 01:18 AM
Edited by Viscid, 13 January 2010 - 02:04 AM.
Posted 17 January 2010 - 03:25 PM
Edited by medicineman, 17 January 2010 - 03:26 PM.
Posted 16 March 2010 - 10:03 PM
Posted 31 March 2010 - 06:55 PM
Posted 31 March 2010 - 08:05 PM
I can verify that for the first time in 2 years, my brain feels normal again. I bombarded my brain with piracetam without glutamine supplementation, and now with glutamine supplementation alone, well, try for yourself
I do however still take a stack of nootropics, but without my L-Glutamine levels being replenished, it was incomplete. For two years I suffered from pointless anxiety and lethargy, not to mention depression and brain fog. This whole fear of glutamate damage had me irrational. I have been taking theanine, huperzine a, magnesium taurate, piracetam, Bacopa, ashwagandha, adderall, you name it, I have tried it. The arsenal was simply incomplete. I have been meditating for years with no benefits. I sat down for the first time last night (only 3 hours of taking 7,000mg of L-Glutamine) and it was effortless pranayama.
Posted 14 June 2010 - 06:51 PM
Edited by stablemind, 14 June 2010 - 07:00 PM.
Posted 15 June 2010 - 01:30 AM
Is there any other nutrient that piracetam depletes besides glutamine and acetylcholine? Would anyone know if glutamine supplementation would pose any risk of excitotoxicity?
Posted 15 June 2010 - 03:35 AM
Is there any other nutrient that piracetam depletes besides glutamine and acetylcholine? Would anyone know if glutamine supplementation would pose any risk of excitotoxicity?
Piracetam is a modulator and not an agonist, so in theory it doesn't deplete anything. It does however open Ca++ channels, so there is an argument for excitotoxicity. It also improves receptor tone, which could be interpreted as an argument against excitotoxicity. Chronic administration results, in addition to neural reregulation, in neural growth (which could be just as significant). I don't think the research results are in yet, so a lot of these reservations seem to be based upon extrapolation. Apart from excitotoxicity, I have seen reservations about stimulant tolerance and even seizure thresholds.
Posted 15 June 2010 - 05:55 AM
I can verify that for the first time in 2 years, my brain feels normal again. I bombarded my brain with piracetam without glutamine supplementation, and now with glutamine supplementation alone, well, try for yourself
I do however still take a stack of nootropics, but without my L-Glutamine levels being replenished, it was incomplete. For two years I suffered from pointless anxiety and lethargy, not to mention depression and brain fog. This whole fear of glutamate damage had me irrational. I have been taking theanine, huperzine a, magnesium taurate, piracetam, Bacopa, ashwagandha, adderall, you name it, I have tried it. The arsenal was simply incomplete. I have been meditating for years with no benefits. I sat down for the first time last night (only 3 hours of taking 7,000mg of L-Glutamine) and it was effortless pranayama.
Same from my side. Glutamine was the missing key in my stack that changed everything.
Posted 15 June 2010 - 01:11 PM
Posted 18 November 2010 - 02:25 AM
Posted 02 February 2011 - 01:48 PM
Posted 06 February 2011 - 01:08 AM
Posted 06 February 2011 - 02:04 PM
Since Piracetam has a positive effect on NMDA receptors, would long-term users of Piracetam have increased benefit from glutamine supplementation?
Would Piracetam and Glutamine be considered synergistic with one another?
We focus on Choline supplementation, but don't take Glutamine into much consideration at all. Why is that?
because glutamine supplementation might be harmful..............................
normally, excess glutamate is just pumped out of the brain via glial cells (i think) but if glutamate does happen to increase due to malfunction or drug induced, there is a chance for damage.
Neurotoxicity is mediated by glutamate at the NMDA receptors. these receptors are double edged..... especially if they are primed and ready for action.....
I can verify that for the first time in 2 years, my brain feels normal again. I bombarded my brain with piracetam without glutamine supplementation, and now with glutamine supplementation alone, well, try for yourself
I do however still take a stack of nootropics, but without my L-Glutamine levels being replenished, it was incomplete. For two years I suffered from pointless anxiety and lethargy, not to mention depression and brain fog. This whole fear of glutamate damage had me irrational. I have been taking theanine, huperzine a, magnesium taurate, piracetam, Bacopa, ashwagandha, adderall, you name it, I have tried it. The arsenal was simply incomplete. I have been meditating for years with no benefits. I sat down for the first time last night (only 3 hours of taking 7,000mg of L-Glutamine) and it was effortless pranayama.
Posted 06 February 2011 - 03:05 PM
Posted 06 February 2011 - 04:31 PM
Posted 07 February 2011 - 07:09 AM
is everybody talking about the same thing? glutamine or glutamate?
Posted 07 February 2011 - 11:08 PM
Posted 08 February 2011 - 10:23 AM
Posted 08 February 2011 - 03:41 PM
Posted 08 February 2011 - 10:28 PM
Posted 08 February 2011 - 11:19 PM
This sounds a bit crazy to be honest. It doesn't sound healthy although I expect it would be a lot of fun if it is as good as what people describe. But so is taking heroin I suppose! It doesn't mean it's a good thing, BUT I am curious. I used to enjoy Piracetam immensely, maybe this could re-ignite my love for the drug. I haven't taken Piracetam for a good 5 months as the last few times I took it I turned into an aggressive, impatient asshole each time!!
Edited by jlspartz, 08 February 2011 - 11:24 PM.
Posted 09 February 2011 - 06:22 AM
Posted 09 February 2011 - 07:32 AM
This sounds a bit crazy to be honest. It doesn't sound healthy although I expect it would be a lot of fun if it is as good as what people describe. But so is taking heroin I suppose! It doesn't mean it's a good thing, BUT I am curious. I used to enjoy Piracetam immensely, maybe this could re-ignite my love for the drug. I haven't taken Piracetam for a good 5 months as the last few times I took it I turned into an aggressive, impatient asshole each time!!
You might want to try a different racetam then. Piracetam and Oxiracetam put me in a good mood, although Aniracetam does the opposite for me (similar to what you describe). Each one affects each person differently. It could also be the choline supplement if you used one. I can't take choline bitartrate or cdp choline - alpha-gpc or natural sources like eggs are the way I must go.
Posted 09 February 2011 - 09:13 PM
Does anyone know if supplementing with L-Glutamine long term is actually safe?
Posted 10 February 2011 - 12:51 AM
Posted 10 February 2011 - 05:09 PM
The magic is back....It was like my first Piracetam experience/OD. But seriously, I took about 5 gms of glutamine this morning with my tired (not very noticeable) Piracetam stack (Piracetam and choline with some lipton iced tea) and indeed I had one of my most "I'm much more lucid/verbal/creative" mornings in a while. So seems like a good inexpensive addition to a stack. In general I find that Piracetam opens up my right brain but it often needs a little push of some type of stimulant (caffeine, DMAE, Sulbutiamine) in order for it to produce a more salient state than my baseline. I'd argue that this is less likely to produce excess glutamate than most other stimulants.
Posted 10 February 2011 - 06:21 PM
Posted 11 February 2011 - 12:39 AM
so there's more chance piracetam will work cus of glutamine? Piracetam alone doesen't work for me.
Posted 11 February 2011 - 01:18 AM
So things that stimulate the brain will tend to enhance Piracetam's effect. So caffeine, ritalin, adderall, modafanil, hydergine, deprenyl will enhance the effect, but also less stimulating cognitive enhancers: DMAE, ALCAR, B-vitamins, choline, sulbutiamine, etc. Glutamine is probably similar. It can certainly also be the case that Piracetam, through its numerous mechanisms of actions, is enhancing or broadening the effect of these other substances.
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