browser,
you really should consider micronized powder with beta-lactoglobulin from say... a whey protein isolate shake. (Its cheaper, and no need to take with alcohol). 12 Capsules is a large amount for anyone, so you are an exceptional case... and not the normal resveratrol user.
1- If dipping non-micronized resveratrol works for you, stop taking the Nitro250.
2- 30mg in one liter... you do know how small 30mg really is?
3- Do the dip, forget the Nitro250 if it works for you.
4- You know, micronized resveratrol = higher absorption.
5- Do the dip, or the alcohol... I have an issue with gum unless it dissolves out right.
Cheers
A
Anthony, not only is the Nitro 250 a gut problem at 12 capsules. The MCT Q is a problem at 12 capsules. This is why I want to go with buccal. Don't need the Q that way.
I have non-micronized on order. I'm ordering enough to make gum, dip and dissolve in alcohol. I dissolved 100 mg. in a much smaller amount of alcohol and swished for a long time. Didn't pickle my mucosa the way the larger portion of rum did. I noticed that the RESV did precipitate out as saliva mixed in.
Be careful holding alcohol in your mouth for long periods. It is carcinogenic with such exposure. Mucosal surface area limitation is more than theory, but good luck. Consider Anthony's suggestion using whey protein as a dispersant.
I've D/Ced the alcohol because it damages the mucosa. So y'all are still promoting the once a day dosing of RESV instead of continuous buccal delivery. Which animal studies had the animals getting a once a day only dose of RESV?
Continuous NAMPT and/or SIRT1 activation by resveratrol would interfere with the CLOCK mediated feedback loops. Something like jet lag, which can be life-shortening. Bear in mind that mice are nocturnal, people are not.
Science. 2009 May 1;324(5927):651-4. Epub 2009 Mar 19.
Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis.
Ramsey KM, Yoshino J, Brace CS, Abrassart D, Kobayashi Y, Marcheva B, Hong HK, Chong JL, Buhr ED, Lee C, Takahashi JS, Imai S, Bass J.
Department of Medicine, Northwestern University Feinberg School of Medicine, 2200 Campus Drive, Evanston, IL 60208-3500, USA.
Comment in:
Science. 2009 May 1;324(5927):598-9.
The circadian clock is encoded by a transcription-translation feedback loop that synchronizes behavior and metabolism with the light-dark cycle. Here we report that both the rate-limiting enzyme in mammalian nicotinamide adenine dinucleotide (NAD+) biosynthesis, nicotinamide phosphoribosyltransferase (NAMPT), and levels of NAD+ display circadian oscillations that are regulated by the core clock machinery in mice. Inhibition of NAMPT promotes oscillation of the clock gene Per2 by releasing CLOCK:BMAL1 from suppression by SIRT1. In turn, the circadian transcription factor CLOCK binds to and up-regulates Nampt, thus completing a feedback loop involving NAMPT/NAD+ and SIRT1/CLOCK:BMAL1.
PMID: 19299583 [PubMed - indexed for MEDLINE]
Redox Rep. 2009;14(4):154-8.
Resveratrol opposite effects on rat tissue lipoperoxidation: pro-oxidant during day-time and antioxidant at night.
Gadacha W, Ben-Attia M, Bonnefont-Rousselot D, Aouani E, Ghanem-Boughanmi N, Touitou Y.
Laboratoire de Biochimie Médicale et Biologie Moléculaire, INSERM U 13, Faculté de Médecine Pierre et Marie Curie, Paris, France.
We investigated the dosing-time dependency of acute resveratrol administration on lipoperoxidation level found in the heart, liver and kidney of male rats synchronized with a 12-h dark-light cycle. Resveratrol was administered by the i.p. route at the middle of the dark (6 h after dark onset, HADO) or light span (18 HADO) and thiobarbituric acid reactive species (TBARS) measured 4 h later at 10 and 22 HADO, respectively. Basal TBARS levels in the three organs were higher during the night span when compared to day span. Resveratrol effect on tissues TBARS was also dosing-time dependent. When administered during the dark phase, resveratrol decreased TBARS levels whereas at the light span, the polyphenol increased TBARS in the three organs. Resveratrol behaved as an antioxidant during the dark span and as a pro-oxidant during the light span. These data suggested a day/night rhythm in basal lipoperoxidation and in resveratrol antioxidant effect.
PMID: 19695122
J Pineal Res. 2010 Jan;48(1):9-19.
Sirtuins, melatonin and circadian rhythms: building a bridge between aging and cancer.
Jung-Hynes B, Reiter RJ, Ahmad N.
Department of Dermatology, University of Wisconsin, Madison, WI 53706, USA.
Histone deacetylases (HDAC) have been under intense scientific investigation for a number of years. However, only recently the unique class III HDAC, sirtuins, have gained increasing investigational momentum. Originally linked to longevity in yeast, sirtuins and more specifically, SIRT1 have been implicated in numerous biological processes having both protective and/or detrimental effects. SIRT1 appears to play a critical role in the process of carcinogenesis, especially in age-related neoplasms. Similarly, alterations in circadian rhythms as well as production of the pineal hormone melatonin have been linked to aging and cancer risk. Melatonin has been found act as a differentiating agent in some cancer cells and to lower their invasive and metastatic status. In addition, melatonin synthesis and release occurs in a circadian rhythm fashion and it has been linked to the core circadian machinery genes (Clock, Bmal1, Periods, and Cryptochromes). Melatonin has also been associated with chronotherapy, the timely administration of chemotherapy agents to optimize trends in biological cycles. Interestingly, a recent set of studies have linked SIRT1 to the circadian rhythm machinery through direct deacetylation activity as well as through the nicotinamide adenine dinucleotide (NAD(+)) salvage pathway. In this review, we provide evidence for a possible connection between sirtuins, melatonin, and the circadian rhythm circuitry and their implications in aging, chronomodulation, and cancer.
PMID: 20025641
Nat Rev Cancer. 2009 Dec;9(12):886-96.
Metabolism and cancer: the circadian clock connection.
Sahar S, Sassone-Corsi P.
Department of Pharmacology, School of Medicine, University of California, Irvine, Irvine, California 92697, USA.
Circadian rhythms govern a remarkable variety of metabolic and physiological functions. Accumulating epidemiological and genetic evidence indicates that the disruption of circadian rhythms might be directly linked to cancer. Intriguingly, several molecular gears constituting the clock machinery have been found to establish functional interplays with regulators of the cell cycle, and alterations in clock function could lead to aberrant cellular proliferation. In addition, connections between the circadian clock and cellular metabolism have been identified that are regulated by chromatin remodelling. This suggests that abnormal metabolism in cancer could also be a consequence of a disrupted circadian clock. Therefore, a comprehensive understanding of the molecular links that connect the circadian clock to the cell cycle and metabolism could provide therapeutic benefit against certain human neoplasias.
PMID: 19935677
Edited by maxwatt, 10 March 2010 - 01:24 AM.