well maybe...
over time modafinil induces the 3a4 enzyme more and more. 3a4 is responsible for the breakdown of most drugs including modafinil. so the more often you take modafinil the quicker it leaves your system. milk thistle is a 3a4 inhibitor which means it will block the breakdown of modafinil and hopefuly nullify the effects modafinil inducing 3a4. well thats the hope atleast what do you guys think?