13 replies to this topic

[j03]

I'm reading a lot of conflicting reports online about taking these two together. Some say it's good, others say it's dangerous.

I was going to take lithium Orotate, Inositol, and Omega 3 for a mood boost and to counter stress induced brain damage, etc.

Can anyone comment on this?

Edit: I had methionine in there but removed it after reading about methionine and methylation in a previous thread. I might replace it with choline.

Edited by k4t, 07 April 2010 - 10:58 PM.

[aaron_e]

I'm reading a lot of conflicting reports online about taking these two together. Some say it's good, others say it's dangerous.

I was going to take lithium Orotate, Inositol, and Omega 3 for a mood boost and to counter stress induced brain damage, etc.

Can anyone comment on this?

Edit: I had methionine in there but removed it after reading about methionine and methylation in a previous thread. I might replace it with choline.

if you start feeling like you aren't getting deep sleep or having time compression episodes then you probably should cut back, but other than that i wouldn't worry. i've only got serotonin excess from mixing prozac with 5htp.

[j03]

Anyone else experience that?

[TigerMask]

I'm reading a lot of conflicting reports online about taking these two together. Some say it's good, others say it's dangerous.

I was going to take lithium Orotate, Inositol, and Omega 3 for a mood boost and to counter stress induced brain damage, etc.

Can anyone comment on this?

Edit: I had methionine in there but removed it after reading about methionine and methylation in a previous thread. I might replace it with choline.

if you start feeling like you aren't getting deep sleep or having time compression episodes then you probably should cut back, but other than that i wouldn't worry. i've only got serotonin excess from mixing prozac with 5htp.

Why would K4T get time compression episodes from this combination? I don't understand.

Is there any reason why lithium and inositol wouldn't be safe together? I may be taking these both soon. I'm fairly sure that lithium depletes inositol, so I thought it may actually be useful.

Also, what exactly are time compression episodes?

Edited by TigerMask, 17 June 2010 - 01:11 PM.

[Lufega]

I would take the lithium and inositol at different times. Or even wait a while before you take inositol to judge better the effects of lithium. Depleting inositol might be one of the ways lithiums benefits come to be. I'm just guessing though.

[Sillewater]

http
://www.imminst.org/forum/index.php?s=&...t&p=411374

That's what the paper I posted in the post above said.

[hippocampus]

I'm still confused: is it ok to take inositol and lithium together or not?

[dear mrclock]

Lithium treatment has been found to inhibit the enzyme Inositol monophosphatase, leading to higher levels of inositol triphosphate.This effect was enhanced further with an inositol triphosphate reuptake inhibitor. Inositol disruptions have been linked to memory impairment and depression.

does this mean lithium cause inositol disurptions long term and hence become problematic, but it solves them by inhibiting inositol short term ? im confused on this.

Edited by dear mrclock, 25 September 2012 - 07:15 AM.

[Raza]

It means lithium increases inositol triphosphate availability on its own, by inhibiting its breakdown. Taking more inositol with that will cause a multiplying effect. So, start out with just lithium, and if you feel like adding inositol after that settles, add it in more gradually than you would otherwise.

Inositol 'disruption' may be linked to depression, but that's surely when inositol gets too low. Considering the gargantuan dosages of inositol that've been found helpful for anxiolysis and depression, multiplying the usual 500-1000mg for sleep may not be such an issue.

That is, insofar as 'inositol triphosphate' is the active form of supplemented inositol and responsible for its effects. If its just a metabolic state somewhere it could have all sorts of random consequences to combine the two. Judging from the wikipedia article it is definitely a active form, though.

Edited by Raza, 25 September 2012 - 08:40 AM.

[dear mrclock]

yeh but it seems to me once you discontinue you will experience inositol levels lowered than normal effect. i guess thats just like anything else on this forum, supplements that you have to take continuesly and not quit, capitalist's dream.

[Raza]

For a short while, probably, if the enzyme upregulated to adjust for its inhibition. That'd normalize shortly, though, and in the meantime could likely be addressed through ordinary inositol supplementation if the difference were perceivable at all.

Altogether, that's not an angle I'd expect trouble from.

[hani]

So lithium prevents the breakdown of inositol, similar to the way SSRIs prevent the reuptake for serotonin? Doesn't that mean that supplementing inositol with lithium multiplies the effect of the latter?

[Jackhill41]

Bump. Thinking of adding a very small dose of lithium orotate (500 mcgs) to my stack which includes about 4 grams inositol.

[niner]

500 mics isn't going to do anything to your inositol level. People using lithium for bipolar disorder take 500-1000 times that amount.