Chemical Compound Effective in Destroying Antibiotic-Resistant Biofilms<h1 id="headline" class="story"></h1> ScienceDaily (Apr. 11, 2010) — Researchers at North Carolina State University have found a chemical compound that, when used in conjunction with conventional antibiotics, is effective in destroying biofilms produced by antibiotic-resistant strains of bacteria such as the Staphylococcus strain MRSA and Acinetobacter. The compound also re-sentsitizes those bacteria to antibiotics.
http://www.scienceda...00408160907.htm
http://www.ncbi.nlm....pubmed/20211901Synergistic Effects Between Conventional Antibiotics and 2-Aminoimidazole-Derived Antibiofilm Agents.Rogers SA, Huigens RW 3rd, Cavanagh J, Melander C.
Abstract2-Aminoimidazoles are an emerging class of small molecules that possess the ability to inhibit and disperse biofilms across bacterial order, class and phylum. Herein, we report the synergistic effect between a 2-aminoimidazole/triazole conjugate and antibiotics toward dispersing pre-established biofilms, cumulating with a three orders of magnitude increase of biofilm dispersion towards Staphylococcus aureus biofilms. Furthermore, we document that the 2-aminoimidazole/triazole conjugate will also re-sensitize multi-drug resistant strains of bacteria to the effects of conventional antibiotics, including MRSA and multi-drug resistant Acinetobacter baumannii.
PMID: 20211901 [PubMed - as supplied by publisher]
A 2-aminobenzimidazole that inhibits and disperses gram-positive biofilms through a zinc-dependent mechanism.
Rogers SA, Huigens RW 3rd, Melander C.
AbstractA number of 2-aminobenzimidazole derivatives were synthesized and screened for their ability to inhibit and disperse bacterial biofilms. From these compounds, a lead 2-aminobenzimidazole was identified that both inhibited and dispersed MRSA, vancomycin-resistant Enterococcus faecium, and Staphylococcus epidermidis biofilms. Mechanistic studies showed that the activity is Zn(II)-dependent, potentially via a direct zinc-chelating mechanism.
http://www.ncbi.nlm....pubmed/19621946
