"The metabolic enhancer piracetam ameliorates the impairment of mitochondrial function and neurite outgrowth induced by ss-amyloid peptide"
AND
Epigallocatechin-3-gallate(GREEN TEA EXTRACT) and curcumin(TUMERIC) suppress amyloid beta-induced beta-site APP cleaving enzyme-1 upregulation.
Shimmyo Y, Kihara T, Akaike A, Niidome T, Sugimoto H.
Department of Neuroscience for Drug Discovery, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan. hsugimot@pharm.kyoto-u.ac.jp
Abstract
Beta-site APP cleaving enzyme-1 (BACE-1), is a rate-limiting enzyme for beta amyloid production. Beta amyloid induces the production of radical oxygen species and neuronal injury. Oxidative stress plays a key role in various neurological diseases such as ischemia and Alzheimer's disease. Recent studies suggest that oxidative stress induces BACE-1 protein upregulation in neuronal cells. Here, we demonstrate that naturally occurring compounds (-)-epigallocatechin-3-gallate and curcumin suppress beta amyloid-induced BACE-1 upregulation. Exposure of beta amyloid 1-42 to neuronal culture increased BACE-1 protein levels. (-)-Epigallocatechin-3-gallate or curcumin significantly attenuated beta amyloid-induced radical oxygen species production and beta-sheet structure formation. These two compounds have novel pharmacological effects that may be beneficial for Alzheimer's disease treatment.(PUREBULK IS GOOD SOURCE)
Curcumin has also been shown to destroy beta amyloid, which no drug on the market can claim to do to my knowledge. Search for how people are getting it absorbed.
Lipoic acid and acetylcarntine could be good , although acetyl carntine does have strong prooxidant effects(couldnt find data) matching its antioxidant effect, be real careful dose at 200mg 2-3 times a day is necessary in older people and check contraindications.
I would get heavy metal test conducted with a challenge, doc's have an aversion to this but its a leading cause of disease in the western world.
I would also get hormone levels looked at by an endocrinologist, money permiting, look at pregnenlonone sulfate and pregnanlonone sulfate
Also exercise 3 times a week is really important, get her to really push her limits, the effects on the brain are immense
Vitamin D supplement, fish oil, magnesium
Edited by haha, 26 April 2010 - 04:54 AM.