2 replies to this topic

[sigma.z.1980]

hi, can DMAE replace CDP as choline source?

Here it says that DMAE is a precursor to choline, but can it be a replacement to choline drugs such as CDP?

[LabRat84]

hi, can DMAE replace CDP as choline source?

Here it says that DMAE is a precursor to choline, but can it be a replacement to choline drugs such as CDP?

Yep, but I don't think it's as well-absorbed, so you need a higher dose for the same effects. Centrophenoxine delivers DMAE across the blood-brain barrier more effectively, though it is more expensive.

CDP-Choline has other benefits. Do a search to find out more about them.

[chrono]

DMAE has a bad rep to some extent. I chose to splash out on Alpha GPC, based on this (among other discussions):

DMAE Profile

Numerous side effects from DMAE treatment have been reported in the literature. These include gastrointestinal disturbances, bad body odor, drowsiness, sedation, retardation, confusion, increased blood pressure, depression, and hypomania; some of these are causes of frequent withdrawal [20, 31-33]. Airborne DMAE is associated with a variety of adverse events (some of which have been reported in humans exposed to high concentrations in a label printing plant), primarily visual disturbances (blurry, halo, and blue-grey vision, corneal opacity, and decrements in visual acuity and contrast sensitivity) and skin irritation [34-36]. However, it is doubtful that oral supplementation will lead to these effects. DMAE also has potential teratogenic effects due to the fact that it inhibits choline uptake [10]. In one study, rat pups fed a choline-deficient diet containing DMAE died within 36 hours of birth, supporting the notion that DMAE does not function as an effective choline precursor [37]. In another experimental study, the presence of choline or acetylcholine offset developmental toxicity due to DMAE [38].

Don't know which of these are of realistic concern, but given the availability of better options and no compelling reason...