From ScienceDaily.com today:
http://www.scienceda...00426081241.htm
This new study is part of the major Betula Project, which, according to the Swedish Research Council, is one of the ten strongest research settings in Sweden and has the goal of studying how the memory changes during aging. It comprises 427 non-demented individuals between the ages of 41 and 81 years. The scientists studied whether individuals with different forms of apolipoprotein E (APOE) have different telomere lengths in their blood cells and whether variations in telomere length is linked to memory capacity, assessed with the help of memory tests. Previous research has described the connection between the form of APOE 4 and cardiovascular disease and dementia. It has also been shown that this variant increases the risk of a type of memory degradation that is most pronounced in older individuals without dementia. This is a degradation of memory in the so-called episodic memory system, which, in simple terms, has the assignment of remembering episodes in life.
In summary the newly published study shows that individuals with APOE 4 have longer telomeres than those with other APOE variants. It was also found that the difference in telomere length between APOE 4 and other APOE variants increased the younger the individuals compared were. In the group that had the variant APOE 4 the individuals with the longest telomeres performed less well on episodic memory tests but not on other tests.
The longer telomeres support the notion that the cells have undergone a lower number of cell divisions and that the differences in length arose at some time prior to the lower age limit for the study. Such reduced cell division early in life may be an explanation for the worse episodic memory of people with the 4 variant compared with that of individuals with other variants. More studies are needed to confirm these findings and to determine through what mechanisms long telomeres are associated with poorer episodic memory and with any other possible APOE 4-associated processes in the body.
A bit less than an "astounding" breakthrough (as may be suggested by the title) but interesting that Longer telomeres are linked to poor episodic memory but not other forms of memory.
