Quick Intro,
So, as I started to mention in a post before, for most of my life I've dealt with various neurological symptoms, including depresion, social anxiety and an essential tremor. Around age 20 I began to develop paranoid schizoprenia. Being a biochemistry student, I've ordered many tests myself and recently uncovered something that may really be of interest to others here.
Last week I had a Lyme Disease - Western Blot drawn, which showed positive for the IgG P41 band. P41 is a flagellin antibody, the tail like structure that all spirochetes have. If you google it, apparently alot of doctors dismiss this antigen as seperate from lyme, even though some think it is a conclusive diagnosis of long-standing lyme (if you dont have syphillis, aids, or periodontal disease, which I already tested negative for).
P41 antibody is the the only known activator of Toll-like receptor 5 (TLR5), which is strongly expressed in the gut endothelial lining, and likely has a role in food allergies associated with mental conditions. It also stimulates Tumour Necrosis Factor, which by itself has alot of implications with mental health.
Here is the signification part...I've yet to get my TNF drawn, but my b12 status tested low, which has alot to do with neurological function. Its also becoming a huge treatment for multiple sclerosis because of its participation in myelination, and people with MS are testing low in B12. So do alot of schizophrenics, which is where P41 connects the dots.
http://www.ncbi.nlm....cles/PMC149400/
Geographical and seasonal correlation of multiple sclerosis to sporadic schizophrenia
Background
Clusters by season and locality reveal a striking epidemiological overlap between sporadic schizophrenia and multiple sclerosis (MS). As the birth excesses of those individuals who later in life develop schizophrenia mirror the seasonal distribution of Ixodid ticks, a meta analysis has been performed between all neuropsychiatric birth excesses including MS and the epidemiology of spirochaetal infectious diseases.
Results
The prevalence of MS and schizophrenic birth excesses entirely spares the tropical belt where human treponematoses are endemic, whereas in more temperate climates infection rates of Borrelia garinii in ticks collected from seabirds match the global geographic distribution of MS. If the seasonal fluctuations of Lyme borreliosis in Europe are taken into account, the birth excesses of MS and those of schizophrenia are nine months apart, reflecting the activity of Ixodes ricinus at the time of embryonic implantation and birth. In America, this nine months' shift between MS and schizophrenic births is also reflected by the periodicity of Borrelia burgdorferi transmitting Ixodes pacificus ticks along the West Coast and the periodicity of Ixodes scapularis along the East Coast. With respect to Ixodid tick activity, amongst the neuropsychiatric birth excesses only amyotrophic lateral sclerosis (ALS) shows a similar seasonal trend.
Conclusion
It cannot be excluded at present that maternal infection by Borrelia burgdorferi poses a risk to the unborn. The seasonal and geographical overlap between schizophrenia, MS and neuroborreliosis rather emphasises a causal relation that derives from exposure to a flagellar virulence factor at conception and delivery. It is hoped that the pathogenic correlation of spirochaetal virulence to temperature and heat shock proteins (HSP) might encourage a new direction of research in molecular epidemiology.
The emphasis I'm trying to make is that this might be more evidence that alot of conditions otherwise blamed on faulty genetics, may be due to chronic infection, which has been suggested by some doctors but dismissed by the majority.
