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[treonsverdery]

at a different item here I wrote about how many phramaceutical molecules that are halogenated have hundreds of times greater physiological activity; the claassic being a comparison of cortisone with fluorocortisones which are 700 times more active per milligram Iwrote to sirtris about chlororesveratrol http://www.imminst.o...mp;#entry341659 but they did not reply; it is a public domain idea

It occurs to me that any of the plant derived supplements might be very much stronger if the plants growth medium were loaded with prechemicals; anything from tryptophan to chlorosucrates

there might even be a technique where you put a branch of leaves at a water container full of likely prechemicals like chlorosucrose or various amino acids then let the leaves dry as herbs once they have absorbed the chemical plus made pharmaceutically valuable metabolites with it

I know thats like cyborgherbalisn yet it might be considered an authentic plant product that way

[niner]

That's actually an interesting idea; that you might be able to get a plant, microbe, or whatever to synthesize a halogenated compound by supplying it with the right halogenated precursor. You would need to know a lot about the pathways involved, and you would probably have a tough time with anything other than fluorine for steric reasons, but "it might just be crazy enough to work!" If you check the literature, it may have already been done.

Oh, and regarding the idea you sent to Sirtris, a pharmaceutical company will never respond to a suggestion from outside, because if they end up using the idea, or more likely if they have already had the same idea and are going forward with it, they fear that the helpful citizen will then ask for money. They would never get it, but it would be an annoying legal distraction. Medicinal chemists are extremely familiar with all manner of molecular modification, and it's really unlikely that someone from outside the industry would have an idea that they hadn't already considered. It's typical for them to make hundreds to thousands of analogs in a single program.

Edited by niner, 21 May 2010 - 04:18 AM.