3 replies to this topic

[kingjames24]

Okay First of all Hi! Im new here and I was just wondering if there's any supplements I could take that might help allow me to enter hyperfocus. For those who dont know what hyperfocus is its that feeling you get when time has passed really fast. Ex) When I was younger my father would take me to get a videogame and I'd return home look at the clock it would be 12:00 start playing the game look back at the clock it would be 9:00 already. However for some reason this doesnt happen to me at all anymore no matter how intresting the thing is im working on even a videogame! I've been researching nueroscience pretty heavily lately and it doesn't make sense.

I'm pretty sure I'm Schizopherenic and one of the believed causes of that is too much dopamine in the frontal lobes or limbic system. I was on concerta for awhile and it definitly brought back my hyperfocus however I started overdosing on it and eventually was taken off it. I believe my overdosing has caused me to become schiz. I hear audio hallucinations. Now I'm definitly more in tuned to what goes on in my head and my suroundings but cant focus on whats in front of me sometimes. I just want to be able to hyperfocus again or focus in general i guess. I'm looking probably to go on a antidepressant, anti psychotic, and psychostimulant.

However all I really care about is the hyperfocus part. Please tell me anything you guys know about hyperfocus brain chemistry wise supplements that may help enter the state. Should i be looking to lower my dopamine levels instead of increasing them>? According to some info I've read hyperfocus is actually brought on by lower levels of dopamine in the frontal lobes. Any Supplements?

[kingjames24]

Okay First of all Hi! Im new here and I was just wondering if there's any supplements I could take that might help allow me to enter hyperfocus. For those who dont know what hyperfocus is its that feeling you get when time has passed really fast. Ex) When I was younger my father would take me to get a videogame and I'd return home look at the clock it would be 12:00 start playing the game look back at the clock it would be 9:00 already. However for some reason this doesnt happen to me at all anymore no matter how intresting the thing is im working on even a videogame! I've been researching nueroscience pretty heavily lately and it doesn't make sense.

I'm pretty sure I'm Schizopherenic and one of the believed causes of that is too much dopamine in the frontal lobes or limbic system. I was on concerta for awhile and it definitly brought back my hyperfocus however I started overdosing on it and eventually was taken off it. I believe my overdosing has caused me to become schiz. I hear audio hallucinations. Now I'm definitly more in tuned to what goes on in my head and my suroundings but cant focus on whats in front of me sometimes. I just want to be able to hyperfocus again or focus in general i guess. I'm looking probably to go on a antidepressant, anti psychotic, and psychostimulant.

However all I really care about is the hyperfocus part. Please tell me anything you guys know about hyperfocus brain chemistry wise supplements that may help enter the state. Should i be looking to lower my dopamine levels instead of increasing them>? According to some info I've read hyperfocus is actually brought on by lower levels of dopamine in the frontal lobes. Any Supplements?

[Lufega]

How about citicoline?? It antagonizes dopamine so it will help you focus and possible control the schizo. some. Right now I'm using 100 mg thiamin a few times a day and this has been surprisingly helpfull with memory and focus as of late. Also, quercetin, about 1 gram single dose, gives me a solid focus.

First administration of cytidine diphosphocholine and galantamine in schizophrenia: a sustained alpha7 nicotinic agonist strategy.
Deutsch SI, Schwartz BL, Schooler NR, Rosse RB, Mastropaolo J, Gaskins B.

Mental Health Service Line, Department of Veterans Affairs Medical Center, Washington DC 20422, USA. Stephen.Deutsch@med.va.gov

Abstract
Converging lines of evidence suggest pathophysiology of alpha7 nicotinic acetylcholine receptors (alpha7 nAChRs) in schizophrenia. This pilot study was designed to test the tolerability, safety, and preliminary efficacy of chronic administration of an alpha7 nAChR agonist strategy involving combination treatment of cytidine diphosphocholine (CDP-choline; 2 g/d), a dietary source of the alpha7 nAChR agonist choline, and galantamine (24 mg/d), a positive allosteric modulator of nAChRs that was prescribed to prevent choline from becoming a functional antagonist and improve the efficiency of coupling the binding of choline to channel opening. The combination of CDP-choline and galantamine was administered to 6 schizophrenic patients with residual symptoms in a 12-week, open-label trial. Patients were maintained on stable dose regimens of antipsychotic medications for 4 weeks before study entry and for the trial duration. All reached target doses of both agents and completed the trial. Transient side effects resolved without slowing of dose titration. Gastrointestinal adverse effects were most common. Of the 6 patients, 5 showed reduction in Clinical Global Impressions severity scores and Positive and Negative Syndrome Scale total scores. Three patients requested continuation of the adjunctive combination at the end of the trial. These results suggest further investigation of the combination of CDP-choline and galantamine as an alpha7 nAChR agonist intervention.

Edited by Lufega, 30 May 2010 - 12:29 AM.

[chrono]

Have you seen a doctor about the auditory hallucinations? If you possibly have a schizo disorder or some kind of sub-threshold psychosis, playing around with your neurotransmitters could be a very, very bad thing.

The time compression you've described is a possible correlate of hyperfocus, but in my experience it isn't central. I get hyperfocus to some extent every time I take adderall (esp. with repeated dosing), but only experience significant time distortion when I'm engaged very deeply (and emotionally) in a single thing for a long time (like your video game example).

I think one reason this state is hard to replicate is the changes in cognition as we age. We're able to more effectively manage complex inputs and thoughts after adolescence, and are increasingly self-aware. I think there's a definite downside to this, as we lose some of the perspective we have as our minds are developing.

So neurologically, ritalin inhibits reuptake of DA and NE. Adderall does this, and additionally increases their release. I'd also be very interested to know what mechanism is responsible for the hyperfocus effect, but it would require more experimentation with selective dopaminergics. I have a feeling that cholinergics might be able to influence attention along this spectrum as well, though I haven't heard of any which operate at the same magnitude as psychostimulants.

For focus/attention in general, there are many topics here. Personally I'd recommend piracetam + ALCAR. But again, I hope you're consulting a doctor—I generally have an anti-clinical bias, but this is one area where I feel such expertise and care is essential.

Edited by chrono, 31 May 2010 - 09:05 PM.