AGE Breakers
scottl 04 Sep 2004
I've just started thinking about AGE Breakers. If this type compound breaks AGEs, and benfotiamine and pyridoxamine just prevent formation of new AGEs, then how did taking benfotiamine improve my father's diabetic neuropathy? Perhaps the body can slowly remove AGEs but it is normally overwhelmed because so many new ones are forming that it can't keep up. So when you add e.g. benfotiamine which prevents the formation of new ones, breakdown of AGEs can exceed formation of new ones.
04 Sep 2004
ALT-711 could also renew declining lung elasticity and soften an enlarged and hardened prostate. But it will be at least 10 years until such drugs, currently undergoing clinical trials, are approved for humans.
It's a good thing Rizzer has ALT-711 now.
ScottL, I don't know how many people here that have researched LE supplements extensively. Among them perhaps nootropi, Zencatholic, LifeMirage, or AORSupport could answer your question properly.
That said, I suppose your conjecture is valid. Perhaps if your father is willing you could administer some ALT-711 concurrently with his benfotiamine and monitor the results as best you can. I don't think he'll be able to get ALT-711 from his doctors based on my quote.
scottl 05 Sep 2004
nootropi 05 Sep 2004
Are we talking a non-diabetic for general anti-aging purposes? If so, what is your present anti-aging regimen?
Are you talking to me?
[:o]
scottl 05 Sep 2004
"what do you guys think of Metformin?"
I was thinking that it would be a reasonable addition, but certainly not near the top of an anti-aging regimen and wondered if he was taking more basic supps B vitamins, E, C, R-ALA, etc.
05 Sep 2004
"...free-radical oxidation and possibly telomere shortening, also contribute to the body's slow decline...."
Now the previous ("free radical oxidation") has been addressed thoroughly through various supplements, but how many supplements out there can stop telomere shortening?
If we only covered these just 3 bases over the duration of a lifetime I assume we would be much farther along in extending the human life span:
-AGE "Breakers" (and inhibitors)
-Extensive anti-oxidant regiment (rather vague and inclusive)
-Stopping or radically slowing down natural telomere shortening
That said I'd love to see someone's LE regiments if they're willing to post it.
strongman 05 Sep 2004
In regards to telomere shortening, I believe I read an article that states carnosine will allow cells to divide for a longer period of time. Also, increased insulin causes cells to divide more rapidly, so anything that lowers insulin levels should help with telomere shortening, such as R-ALA, Chromium, Bilberry Extract, along with ofcourse the old standby Calorie Restriction.
Also there is a supplement which I started taking called Indium Sulfate which can lengthen the time red blood cells live from 90 to 120 days.
Cheers,
Strongman.
scottl 06 Sep 2004
Do you have a reference/link for the indium?
Cosmos,
I'm beginning to realize that my overall view of anti-aging is deficient in certain areas and needs to be re-vamped.
FYI: you probably know that LifeMirage's regimen, or at least part of it as of May 16, 2004
is here:
http://www.imminst.o...t=0
broken down by category e.g. Glycation Breakers, Glycation Inhibitors, Mitochondria Antioxidants, SOD Upregulators, Mitochondria Upregulators, Cellular Membrane Agents...
Paul Wakfer (formerely Tom Matthews) regimen is here in case you aren't aware
http://morelife.org/...is-regimen.html
Mind 06 Sep 2004
I would tend to think longer term side effects could be discoverd in a couple of years. I mean...our diagnostic tools are getting very good. We can detect even the beginnings of detrimental side effects and determine if worse is to come.
Has anyone heard of this compound or its derivatives and are there any known side effects?
scottl 06 Sep 2004
Checkout morelife.com and Paul Wakfer's regimen which includes several interesting compounds. ALT-711 info is here:
http://morelife.org/...ms/ALT-711.html
"why does the article state that it will be 10 years before ALT-711 could be approved through the regulatory process."
Do you know anything about the FDA and the drug approval process? I've given presentations for them when I worked for a drug company in one of my previous lives. Suffice it to say the new drug approval process is messy. The fact that this is a new category of drug makes it even more messy
07 Sep 2004
I believe that people over the age of 40 should have their own extensive LE regiment. In fact I would start using them in my late 20's, before then a healthy diet and exercise combined with the antioxidants available in foods should suffice. That's why my focus remains nootropics over life extension at the moment, and it always be that way even when I start a more extensive life extension regiment eventually.
scottl 07 Sep 2004
Good point.
Personally I'm currently looking into the area of things that increase catalase/SOD. I'll start a new thread in a day or three on this.
rahein 07 Sep 2004
strongman 07 Sep 2004
In regards to the Indium I've found two places that sell it
http://www.eastparkr...c.html?src=g002
and here
http://www.lifestar....s/ProdForm.html
The second one is cheaper, and I have only ever ordered from there. Not sure if there is a difference in the products.
Cheers,
Strongman.
shiver 14 Sep 2004
-Stopping or radically slowing down natural telomere shortening
How about "MitoQ"?
http://www.blackwell...03.00040.x/abs/
http://internaf.org/ataxia/MitoQ.html
shiver 15 Sep 2004
ryan1113 15 Sep 2004
I have heard, but have no link handy, that large doeses C has a has a small effect on slowing the shorting of telomeres. C is cheap and has so many other benifits that I take 3-5g a day.
This may be because it spares glutathione.
Glutathione has recently been shown to regulate telomerase activity. See: PMID: 15184392
So, one may wish to take substances which upregulate glutathione levels (NAC, R(+)ALA, etc.) and also take things which help to deal with H2O2 (thiodipropionic acid, dilauryl thiodipropionate, quercetin, etc -- in theory these would be much more effective than vitamin c in sparing glutathione.
goku 23 Oct 2006
goku 24 Oct 2006
But does ANYONE know where to get this? It would likely be the best thing out there, period. Anyone selling???
curious_sle 25 Oct 2006
Um, maybe a small batch? :-) anyone?
opales 26 Oct 2006
zoolander 26 Oct 2006
https://www.lenutri.com/order/
opales 26 Oct 2006
It looks as though they are selling the product under the name PhenCarLE. They are selling it as a research product and you will have to agree that you are buying it for research purposes
https://www.lenutri.com/order/
I am not sure if it is a good decision to put ALCAR in the same package. ALCAR has IMO question marks attached to it i.e. slightly increased mortality in the LEF lifespan study, and it appears to be of help mostly to the old animals with more damaged mitochondria. Subjectively, alcar appears to make me somewhat anxious.
ALT-711s AGE breaking mechanism OTOH would suggest that benefits are derived regardless of age.
doug123 26 Oct 2006
See here to see a little bit about what makes a drug safe.
Yes, it may be ironic to hear that from me considering my encounter with the government; however, to be honest, the laws surrounding sales of many of the compounds I was selling were (and still are!) grey area for FDA and are implemented differently state to state. I know at least one other business who had his company shut down and had his nootropics confiscated by the FDA. And this other company did not get their inventory back in this case. I guess that's because the FDA is a federal agency and I had encounter with a state organization.
I also like to know that the chain of custody involves FDA registered bottling and encapsulation routines. I have submitted copies of my bottling and encapsulation invoices from FDA registered facilities to either prometheus, jaydfox, and/or BruceKlein to back my claim that I use(d) such facilities. I don't want to expose my bottler to any drama, so I submit my invoices to these individuals because they are trusted in this community.