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LongeCityAdvocacy & Research for Unlimited Lifespans
AGE Breakers
Started by
nootropi
, Sep 04 2004 05:36 PM
31 replies to this topic
#2
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Posted 04 September 2004 - 06:26 PM
Nootropi,
I've just started thinking about AGE Breakers. If this type compound breaks AGEs, and benfotiamine and pyridoxamine just prevent formation of new AGEs, then how did taking benfotiamine improve my father's diabetic neuropathy? Perhaps the body can slowly remove AGEs but it is normally overwhelmed because so many new ones are forming that it can't keep up. So when you add e.g. benfotiamine which prevents the formation of new ones, breakdown of AGEs can exceed formation of new ones.
I've just started thinking about AGE Breakers. If this type compound breaks AGEs, and benfotiamine and pyridoxamine just prevent formation of new AGEs, then how did taking benfotiamine improve my father's diabetic neuropathy? Perhaps the body can slowly remove AGEs but it is normally overwhelmed because so many new ones are forming that it can't keep up. So when you add e.g. benfotiamine which prevents the formation of new ones, breakdown of AGEs can exceed formation of new ones.
#3
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Posted 04 September 2004 - 07:51 PM
ALT-711 could also renew declining lung elasticity and soften an enlarged and hardened prostate. But it will be at least 10 years until such drugs, currently undergoing clinical trials, are approved for humans.
It's a good thing Rizzer has ALT-711 now.
ScottL, I don't know how many people here that have researched LE supplements extensively. Among them perhaps nootropi, Zencatholic, LifeMirage, or AORSupport could answer your question properly.
That said, I suppose your conjecture is valid. Perhaps if your father is willing you could administer some ALT-711 concurrently with his benfotiamine and monitor the results as best you can. I don't think he'll be able to get ALT-711 from his doctors based on my quote.
#7
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Posted 05 September 2004 - 04:12 AM
Sorry Nootropi, I really need to learn to use the quote feature. No I was replying to Stellar who asked:
"what do you guys think of Metformin?"
I was thinking that it would be a reasonable addition, but certainly not near the top of an anti-aging regimen and wondered if he was taking more basic supps B vitamins, E, C, R-ALA, etc.
"what do you guys think of Metformin?"
I was thinking that it would be a reasonable addition, but certainly not near the top of an anti-aging regimen and wondered if he was taking more basic supps B vitamins, E, C, R-ALA, etc.
#8
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Posted 05 September 2004 - 08:02 AM
As I said before, it would be quite difficult to come up with an ideal anti-aging regiment. Let's take some tips from the articles first and address some issues from there.
"...free-radical oxidation and possibly telomere shortening, also contribute to the body's slow decline...."
Now the previous ("free radical oxidation") has been addressed thoroughly through various supplements, but how many supplements out there can stop telomere shortening?
If we only covered these just 3 bases over the duration of a lifetime I assume we would be much farther along in extending the human life span:
-AGE "Breakers" (and inhibitors)
-Extensive anti-oxidant regiment (rather vague and inclusive)
-Stopping or radically slowing down natural telomere shortening
That said I'd love to see someone's LE regiments if they're willing to post it.
"...free-radical oxidation and possibly telomere shortening, also contribute to the body's slow decline...."
Now the previous ("free radical oxidation") has been addressed thoroughly through various supplements, but how many supplements out there can stop telomere shortening?
If we only covered these just 3 bases over the duration of a lifetime I assume we would be much farther along in extending the human life span:
-AGE "Breakers" (and inhibitors)
-Extensive anti-oxidant regiment (rather vague and inclusive)
-Stopping or radically slowing down natural telomere shortening
That said I'd love to see someone's LE regiments if they're willing to post it.
#9
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Posted 05 September 2004 - 06:06 PM
cosmos,
In regards to telomere shortening, I believe I read an article that states carnosine will allow cells to divide for a longer period of time. Also, increased insulin causes cells to divide more rapidly, so anything that lowers insulin levels should help with telomere shortening, such as R-ALA, Chromium, Bilberry Extract, along with ofcourse the old standby Calorie Restriction.
Also there is a supplement which I started taking called Indium Sulfate which can lengthen the time red blood cells live from 90 to 120 days.
Cheers,
Strongman.
In regards to telomere shortening, I believe I read an article that states carnosine will allow cells to divide for a longer period of time. Also, increased insulin causes cells to divide more rapidly, so anything that lowers insulin levels should help with telomere shortening, such as R-ALA, Chromium, Bilberry Extract, along with ofcourse the old standby Calorie Restriction.
Also there is a supplement which I started taking called Indium Sulfate which can lengthen the time red blood cells live from 90 to 120 days.
Cheers,
Strongman.
#10
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Posted 06 September 2004 - 12:58 AM
Strongman,
Do you have a reference/link for the indium?
Cosmos,
I'm beginning to realize that my overall view of anti-aging is deficient in certain areas and needs to be re-vamped.
FYI: you probably know that LifeMirage's regimen, or at least part of it as of May 16, 2004
is here:
http://www.imminst.o...t=0
broken down by category e.g. Glycation Breakers, Glycation Inhibitors, Mitochondria Antioxidants, SOD Upregulators, Mitochondria Upregulators, Cellular Membrane Agents...
Paul Wakfer (formerely Tom Matthews) regimen is here in case you aren't aware
http://morelife.org/...is-regimen.html
Do you have a reference/link for the indium?
Cosmos,
I'm beginning to realize that my overall view of anti-aging is deficient in certain areas and needs to be re-vamped.
FYI: you probably know that LifeMirage's regimen, or at least part of it as of May 16, 2004
is here:
http://www.imminst.o...t=0
broken down by category e.g. Glycation Breakers, Glycation Inhibitors, Mitochondria Antioxidants, SOD Upregulators, Mitochondria Upregulators, Cellular Membrane Agents...
Paul Wakfer (formerely Tom Matthews) regimen is here in case you aren't aware
http://morelife.org/...is-regimen.html
#11
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Posted 06 September 2004 - 10:32 PM
This all sounds great, but if animal trials have already been done, why does the article state that it will be 10 years before ALT-711 could be approved through the regulatory process. Holy cow, that is a long time for such a promising supplement.
I would tend to think longer term side effects could be discoverd in a couple of years. I mean...our diagnostic tools are getting very good. We can detect even the beginnings of detrimental side effects and determine if worse is to come.
Has anyone heard of this compound or its derivatives and are there any known side effects?
I would tend to think longer term side effects could be discoverd in a couple of years. I mean...our diagnostic tools are getting very good. We can detect even the beginnings of detrimental side effects and determine if worse is to come.
Has anyone heard of this compound or its derivatives and are there any known side effects?
#12
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Posted 06 September 2004 - 10:45 PM
Hi Mind,
Checkout morelife.com and Paul Wakfer's regimen which includes several interesting compounds. ALT-711 info is here:
http://morelife.org/...ms/ALT-711.html
"why does the article state that it will be 10 years before ALT-711 could be approved through the regulatory process."
Do you know anything about the FDA and the drug approval process? I've given presentations for them when I worked for a drug company in one of my previous lives. Suffice it to say the new drug approval process is messy. The fact that this is a new category of drug makes it even more messy
Checkout morelife.com and Paul Wakfer's regimen which includes several interesting compounds. ALT-711 info is here:
http://morelife.org/...ms/ALT-711.html
"why does the article state that it will be 10 years before ALT-711 could be approved through the regulatory process."
Do you know anything about the FDA and the drug approval process? I've given presentations for them when I worked for a drug company in one of my previous lives. Suffice it to say the new drug approval process is messy. The fact that this is a new category of drug makes it even more messy
#13
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Posted 07 September 2004 - 02:40 AM
Scott, I would look at LifeMirage's LE regiment over the one you linked to earlier. He's broken down the supplements into their intended uses and I would say that his knowledge and experience in this area is superior to that of some of the more avid LE regiment users. His regiment is not complete though, and I'm sure even now we could add on some supplements that he has missed but it's a good place to start.
I believe that people over the age of 40 should have their own extensive LE regiment. In fact I would start using them in my late 20's, before then a healthy diet and exercise combined with the antioxidants available in foods should suffice. That's why my focus remains nootropics over life extension at the moment, and it always be that way even when I start a more extensive life extension regiment eventually.
I believe that people over the age of 40 should have their own extensive LE regiment. In fact I would start using them in my late 20's, before then a healthy diet and exercise combined with the antioxidants available in foods should suffice. That's why my focus remains nootropics over life extension at the moment, and it always be that way even when I start a more extensive life extension regiment eventually.
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Posted 07 September 2004 - 10:17 PM
scottl,
In regards to the Indium I've found two places that sell it
http://www.eastparkr...c.html?src=g002
and here
http://www.lifestar....s/ProdForm.html
The second one is cheaper, and I have only ever ordered from there. Not sure if there is a difference in the products.
Cheers,
Strongman.
In regards to the Indium I've found two places that sell it
http://www.eastparkr...c.html?src=g002
and here
http://www.lifestar....s/ProdForm.html
The second one is cheaper, and I have only ever ordered from there. Not sure if there is a difference in the products.
Cheers,
Strongman.
#17
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Posted 14 September 2004 - 07:55 PM
-Stopping or radically slowing down natural telomere shortening
How about "MitoQ"?
http://www.blackwell...03.00040.x/abs/
http://internaf.org/ataxia/MitoQ.html
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Posted 15 September 2004 - 10:16 PM
I have heard, but have no link handy, that large doeses C has a has a small effect on slowing the shorting of telomeres. C is cheap and has so many other benifits that I take 3-5g a day.
This may be because it spares glutathione.
Glutathione has recently been shown to regulate telomerase activity. See: PMID: 15184392
So, one may wish to take substances which upregulate glutathione levels (NAC, R(+)ALA, etc.) and also take things which help to deal with H2O2 (thiodipropionic acid, dilauryl thiodipropionate, quercetin, etc -- in theory these would be much more effective than vitamin c in sparing glutathione.
#26
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Posted 25 October 2006 - 04:22 PM
um, i'd like some too but then again i'm too young to mess arround with it yet and since my bloodpreasure is fairly ok (65~70/110) i don't really need it yet. Plus i use asthaxantin and ellagitanin to keep atherosklerosis at bay (besides several antiinflamatory supplements) thus, i guess i'm well off without it.
Um, maybe a small batch? :-) anyone?
Um, maybe a small batch? :-) anyone?
#28
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Posted 26 October 2006 - 08:08 AM
It looks as though they are selling the product under the name PhenCarLE. They are selling it as a research product and you will have to agree that you are buying it for research purposes
https://www.lenutri.com/order/
https://www.lenutri.com/order/
#29
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Posted 26 October 2006 - 11:01 AM
It looks as though they are selling the product under the name PhenCarLE. They are selling it as a research product and you will have to agree that you are buying it for research purposes
https://www.lenutri.com/order/
I am not sure if it is a good decision to put ALCAR in the same package. ALCAR has IMO question marks attached to it i.e. slightly increased mortality in the LEF lifespan study, and it appears to be of help mostly to the old animals with more damaged mitochondria. Subjectively, alcar appears to make me somewhat anxious.
ALT-711s AGE breaking mechanism OTOH would suggest that benefits are derived regardless of age.
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Posted 26 October 2006 - 06:11 PM
I wouldn't touch "research chemicals" like ALT-711 myself at this time with a ten foot pole unless I was 100% sure they were made as a pharmaceutical drug and were independently tested and proven free of trace heavy metals, microbiological contamination, and purity quantified by HPLC or mass spec analysis in the range of 99%. I'd like to see a copy of an independent assay before even thinking about purchasing considering ALL the ALT-711 on the market (except for Alteon's) is made in Chinese "chemical factories"...and look at all the contamination in unregualted supplements (check consumerlab.com). I would expect the likelihood of contamination and low quality to be even more prevalent in brands not tested by consumerlab.com -- these companies are always on their toes at least...
See here to see a little bit about what makes a drug safe.
Yes, it may be ironic to hear that from me considering my encounter with the government; however, to be honest, the laws surrounding sales of many of the compounds I was selling were (and still are!) grey area for FDA and are implemented differently state to state. I know at least one other business who had his company shut down and had his nootropics confiscated by the FDA. And this other company did not get their inventory back in this case. I guess that's because the FDA is a federal agency and I had encounter with a state organization.
I also like to know that the chain of custody involves FDA registered bottling and encapsulation routines. I have submitted copies of my bottling and encapsulation invoices from FDA registered facilities to either prometheus, jaydfox, and/or BruceKlein to back my claim that I use(d) such facilities. I don't want to expose my bottler to any drama, so I submit my invoices to these individuals because they are trusted in this community.
See here to see a little bit about what makes a drug safe.
Yes, it may be ironic to hear that from me considering my encounter with the government; however, to be honest, the laws surrounding sales of many of the compounds I was selling were (and still are!) grey area for FDA and are implemented differently state to state. I know at least one other business who had his company shut down and had his nootropics confiscated by the FDA. And this other company did not get their inventory back in this case. I guess that's because the FDA is a federal agency and I had encounter with a state organization.
I also like to know that the chain of custody involves FDA registered bottling and encapsulation routines. I have submitted copies of my bottling and encapsulation invoices from FDA registered facilities to either prometheus, jaydfox, and/or BruceKlein to back my claim that I use(d) such facilities. I don't want to expose my bottler to any drama, so I submit my invoices to these individuals because they are trusted in this community.
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