How to Potentiate Modafinil
pheonickx
20 Jul 2010
Caffeine and piracetam seemed to have done the trick in the past but not too sure now.
please shoot your ideas on how to get about this .......thankyou so much!!
Animal
20 Jul 2010
chrono
20 Jul 2010
I'm curious, are there any potential consequences to taking DPR with modafinil (acute or chronically), or is this a generally safe combination? (I haven't looked into modafinil's MOA that thoroughly yet).Deprenyl will potentiate it, but it takes a couple of weeks to reach full effect.
Animal
20 Jul 2010
I'm curious, are there any potential consequences to taking DPR with modafinil (acute or chronically), or is this a generally safe combination? (I haven't looked into modafinil's MOA that thoroughly yet).Deprenyl will potentiate it, but it takes a couple of weeks to reach full effect.
I would assume it's safe since modafinil is only mildly dopaminergic through a secondary mechanism, so I doubt there will be any neurotoxicity due to excess dopaminergic oxidative stress. I have consumed this combination many times and I must say it doesn't feel toxic (obviously not a conclusive indicator) in that the potentiation is only in duration and not intensity of effect.
Of course I could be wrong, but good luck finding a study on this.
Personally I would never take deprenyl solely for the purpose of potentiating modafinil, it has too many side-effects, but I take the deprenyl for other reasons.
NR2(x)
21 Jul 2010
You spot on about deprenyl, the casacades come together, Im interested how you knew?
Modafinil shows some really interesting changes in some specific protien buts its MOA is through amine bonding, similar to amphetamine.
My concern with using caffeine is that it enhances narrow task positive functions while deminishing fluency and the holistic mind, so maybe for some task but not for others, and as a final year med student i imagine your really starting to have to use higher end function.
Exercise?
Memantine could be interesting in a low dose but both can show NMDA antagonistic effects
pheonickx
21 Jul 2010
piracetm
centrophenoxine
vinpocetine
pyritinol
im really hoping synergy gets about by itself own self LOL
Deprenyl and Memantine have been suggested so far but dont seem to have much feasibility cred.
If anyone else has any ideas or experiments they ran .......please toss them about
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aLurker
21 Jul 2010
NR2(x)
21 Jul 2010
Pyritinol,speculatively could have some dangers in higher dose through pathway Pyridoxine toxicity, requires high as dose
Heisenberg
21 Jul 2010
pheonickx
22 Jul 2010
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Wylie
22 Jul 2010
im starting to get a feeling that there's no substance out there that enhances the effects of modafinil ......no bonnine for my clyde :( .... i was assuming thered be smthg like DMAE for Piracetam type for syngery for modafinil too :(
Nicotine gum. Cigs even more so, but obviously an even worse idea.
Seriously, no nootropic will even come close in enhancing modafinil like Nicotine. I can not only personally attest to this, but it makes perfect sense; the mild dopamine release of modafinil with the reuptake effects of the nicotine...
Gum by itself will never be as addictive as cigs but this is still something to be careful with. I've not been a regular smoker for years, but with those, the addict will crave a smoke and at least know their mood is effected and why. With the gum, I find that I never crave it; as a result I'll start to become moody and won't realize it.
So, there's your answer. :D The best potentiator you could ask for, but it's a really bad idea.... just order more. :D
kbal
22 Jul 2010
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Nasal cancer? Can't find much evidence, but not a lot of people use snuff, hopefully my nose won't fall off :(
But you do look like an junkie- snuffing brown powder. If somebody asks me what is that I'm doing, I just reply that I'm snuffing brown cocaine
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pheonickx
23 Jul 2010
but where is my magic syngergy!!!! no thelma to my louise?
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pheonickx
23 Jul 2010
dilenja
23 Jul 2010
Animal
23 Jul 2010
and since this keeps coming up over and over and over again : NO I CANNOT BUY MORE IM FLAT EFFIN BROKE!
Then how do you expect to buy a potentiator? Most of the substances mentioned in this thread are fairly expensive.
zeropoint
23 Jul 2010
NR2(x)
25 Jul 2010
I would not use more 1.5mg donepezil in any 24hour period, 5mg ed will make you depressed and sick.
The Article on Sciencedirect; Botox for the brain: enhancement of cognition.
2. Cognitive enhancement
2.1. Currently available enhancers
2.1.1. Donepezil
2.1.2. Modafinil
2.1.3. Dopamine agonists: d-amphetamine, bromocriptine and pergolide
2.1.4. Guanfacine
2.1.5. Methylphenidate
(I believe this maybe a ranked list)
5. General principles of enhancement
5.1. The inverted U-shape
5.1.1. Non-linear dose response curves
5.1.2. Baseline dependency
5.2. Trade-offs
5.2.1. Long-term memory versus working memory
5.2.2. Stability versus flexibility of long-term memory
5.2.3. Stability versus flexibility of working memory
5.2.4. Cognition versus mood
5.3. Summary
waldemar
25 Jul 2010
pheonickx
26 Jul 2010
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OMG!! this be hella exciting! :D ........okay pple gear up ..my posting my results soon!
![:|o](http://www.imminst.org/forum/public/style_emoticons/default/ohmy.gif)
pheonickx
26 Jul 2010
i might ace the USMLE after all
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chilp
26 Jul 2010
http://www.drugs.com...um-oxybate.html
Sodium oxybate is a central nervous system depressant. It is used to treat cataplexy (sudden loss of muscle strength) and reduce daytime sleepiness in patients with narcolepsy.
A recent study, but no abstract :-(
http://www.ncbi.nlm....pubmed/20643579
Animal
26 Jul 2010
forgot to mention the red pill is donezepil and modafinil taken together
i might ace the USMLE after all
Why do you think an acetylcholinesterase inhibitor is going to potentiate modafinil? Besides there are more effective and cheaper ACE inhibitors available.
Imagination
26 Jul 2010
Animal
26 Jul 2010
What nootropic effects do you actually get from it though? I have only tried it the once and felt awake but nothing really in the nootropic sense, a 30 minute nap in the afternoon seems to works the same way. I may try it again but have not really had a chance, don't really like experimenting on work days encase I react badly!
Personally I think it only exhibits significantly noticeable effects on those who suffer from fatigue. If you are healthy in this regard it won't feel like more then a cup of coffee since it promotes wakefulness rather then stimulates. Some people have a completely unrealistic expectation of modafinil, as if it'll affect them like amphetamine or something.
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pheonickx
27 Jul 2010
plus the concept of -
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NR2(x)
28 Jul 2010
Modafinil has shown a strong ability to enhance intelligence in people with an IQ below 140. The improvements are chiefly in working memory and tend not to be noticed by the individual. The enhancement is chiefly through dopamine like effects. source;american air force studies
Edited by NR2(x), 28 July 2010 - 05:19 AM.
Animal
28 Jul 2010
Then again if you have an IQ over 140 you can't really complain too much.
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