Depth Charge: Dive into Your OceanThe radical hypothesis is about depth, sleep and awakeness.
Sleep is the regen cycle for brain and body. Sleepiness is the sign that the brain needs regen.
How much regen it needs depends on lots of things, and how well sleep works to regen depends too on a lot of things.
The idea is that for those who get sleepy, piracetam is doing a perfect job. The racetams cause the brain to
deepen itself. The enhanced sharpness of vision, colour saturation, higher functioning in both daytime and sleep. All these things are end results of a process of deepening.
When I say deepening I mean something very different from what stimulants do, which is overcrank the speed machinery to yield temporary gains at the expense of lots of things over time, including depth. Depth is the magic, the density of neurofunctionality, which shows up in complex thought, memory, visualization, and all those other deep things that people who want to be smart desire.
There's an inherent polarity between depth and speed. They're exchangeable, with the sum total or multiplicative total of both being the innate total capacity of an individual person. The racetams do a nice trick by making the brain open into new depth, but for those who have compromised speed, they will notice a temporary or even permanent decrease in wakefulness.
The crash and tiredness after stimulants, and ultimately the need for more sleep - which itself is less productive due to wearout of metabolic and other machinery.
By forcing the brain to increase its depth due to increased receptor availability and saturation, the racetams create an enhanced requirement - not just for choline and oxygen, but for something else crucial to the functioning of all that shiny new complexity and depth - sleep! Better sleep and more REM are needed, and most subjects experience these on piracetam. That's because the
racetams are both the cause and the cure, all wrapped into one molecule. But even that has its limits.
Sleep is the maintenance cycle of depth. Depth is burned during the day even under normal conditions. Very powerful stimulants like amphetamines are so effective at depth-burning that they can create total psychosis with high doses or prolonged use. Insanity is the ultimate reaction to completely unnatural depth->speed/wakefulness exchange.
It's all really about fundamental priorities that evolution wired into the organism since very long ago. It had to choose between two conflicting things, speed/wake and depth maintenance. With a combined limit, an optimal balance would have to be found. Today, how each individual decides the balance is both predetermined by genetics and consciously decided by habits of living. The soft limit is conscious choice and the hard limit is genetics.
When I haven't had enough sleep, my vision shifts back toward lower colour saturation, less sharpness, and lower brightness dynamic range. Thoughts too come not only slower, but are more trivial. Higher level function is degraded, until more sleep is obtained.
Now to address those who get tired from piracetam or another racetam. The racetams create a
demand for sleep because they activate depth. Depth has a high price upfront, and a long but slow payoff that is greater than the sum of its contributions over time

Almost the opposite of stimulants, which have a low price upfront and a long but slow degradation that is greater than the sum of its withdrawals over time

Stimulants burn depth to yield temporary wakefulness and speed. Long-term use causes a loss in not only depth but ability to regen during sleep, both by direct disruption of the sleep cycle, and deprivation of supporting factors which allow recovery to proceed.
Genetics plays a large role too.
If the brain has a permanent depth limit either due to genetics, chronic lack of sleep, or degradation of supporting systems (adrenals, etc.), then piracetam will create
unfulfillable demand for regen, which will result in regen spillover into waking hours (sleepiness!). If piracetam doesn't reach an individual's saturation limit - the most their brain system can deepen, then another racetam might get closer or even go beyond either their temporarily regenerable limit (adaptability priority exchange limit) or their genetic total limit. In both cases daytime sleepiness is the result, but in the first case it can be overcome with time, while in the second it can never be overcome

I want to pursue my saturation limit until I cannot go any further and become sleepy or unawake during the day, and it doesn't remedy in at least a month. That's the timelimit I figure, for the adaptive regen limit.
When I say unfulfillable, I don't necessarily mean permanently unfulfillable. The brain+support system can 'catch up'. That takes time, and depends on the ability of primary and secondary systems to restructure and provide the needed factors.
To offer a bit of evidence for catch-up, I have a PM record with another forum user who also experienced sleepiness. After I encouraged him to continue (dose moderation helps close the unfulfillability gap by lowering the daily restructuration demand gap) - after several weeks his sleepiness ended

None of these ideas predicts how any one individual responds, but it could be useful.
For example, in my case aniracetam - which is more powerful than piracetam - stimulates the intensification of depth via physical restructuring that requires even more sleep than I currently get.
So if I take it, I feel not quite but almost sleepy. So it will take time, and careful sleep hours, and after that my brain will have finished its new works, and I'll return to regular sleep and bright, shiny wakefulness.
This idea also explains why, after taking those stronger racetams, I felt in the days afterwards like I was floating up from the depths, with deeper thoughts and greater awareness. It was waking up to something more than before.
Admittedly, I took large doses of aniracetam, pramiracetam, and oxiracetam. I did so on this hunch, that they would produce maximal depth with a large debt which would be payable in sleepiness to start with. And it worked out exactly like that.
Edited by Isochroma, 29 November 2009 - 10:27 PM.