First of all, I'm "biased" towards evidence based medicine.
Over/Undermethylation and the like seem to be mostly speculations from alternative medicine enthusiasts, with no clinical trials to back it up. Most of the time not even their theories make sense.
But fwiw; http://en.wikipedia....atry#Histadelia
Megadoses of methionine and vitamin b6, if you really want to go that way.
Also, eliminating/restricting folate, cobalamin or any other nutrient intake below the rda would be a very bad idea.
Edit: This topic has been discussed several times already, but I believe I saw your name already in those threads. For a more enlightened post, read here: http://www.imminst.o...ndpost&p=402438
Although I appreciate your input maybe your not the person I need information from?
First and foremost I don't know for sure I have high levels of histamine. This is something I am going to be tested for soon. The idea of this thread is sheerly hypothetical. If I discover I have this condition then having answers on what I can do to lower histamine, but at the same time increase methylation, is going to be crucial to improving my life.
You seem very skeptical of histadelia, which is your right. Personally I don't see how having too much histamine (well, anything out of normal range) would be the sort of thing an individual wouldn't notice. It's like having too much estrogeon or testosterone - there are going to be implications for that and I certainly beleive that an individual would tend to notice negative traits (so lets say I have ridiculously high testosterone - you can bet your sweet ass I may suffer from the odd moment of aggression or irritability).
So yeah I do believe that people who have elevated levels of histamine are going to suffer from common traits. Even the medical profession would be savvy to this. Infact I have spoken to my own doctor (about 7yrs ago) about getting tested for this after we had exhausted most options for trying to treat my persistant depression. So how you claim this is pure specualtion from alternative medical enthusiasts is a bit of a patronising point of view. Just because you don't beleive it, it doesn't mean its wrong.
Also, no offence but I don't think you understood what I was actually asking. I'm not interested in how methylation works. I know how it works. I'm not asking a basic question.
Just suggesting mega doses of methionine and b6 is a bit basic in itself. I could add calcium, magnesium, vitamin C and TMG to that list - there are other things too that have been talked about with regards to lowering levels of elevated histamine.
OK so what I'm after here (sorry if I wasn't clear in my original post).... I have read that folic acid is essential for healthy methylation. I have also read that people with elevated levels of histamine would do well to avoid folic acid/b12. Not avoid them totally because that would be purely unhealthy (I don't have any intention of doing this and never implied in my original post that I was going to cut them out).
Here's where the contradiction comes (hence the title - it was a big clue about the point I was trying to make).....
How do I ensure healthy methylation (which as I've said I know all about , so please no lectures on how it works) which needs folic acid/b12 (both crucial components).....
But also I want to lower histamine..... therefore.......Do I limit folic acid intake within a certain range?
How can I achieve both???? I'd love my methylation to be amazing but by limiting folic acid/b12 it seems I'm pretty handicapped if I want to lower histamine.
Oh and finally - another point. I've never posted on any methylation threads (apart from one SAM-e thread where I commented on an experiment with a 1600mg dose) so where you got that idea is beyond me.
Anyway I'm not having a rant I'm just trying to make this concise and clear, I don't want this thread moving in pointless directions (because as you say there are already enough methylation threads - and yes I have read them - many times over)
