10 replies to this topic

[stablemind]

Pentoxifylline + piracetam seem to produce much stronger effects than either alone.

Arch Gerontol Geriatr. 1985 Jul;4(2):141-55.
Haemorheological pattern in initial mental deterioration: results of a long-term study using piracetam and pentoxifylline.

Parnetti L, Ciuffetti G, Mercuri M, Senin U.

A group of 80 elderly subjects affected with recent onset (less than 6 mth) slight to moderate mental deterioration was observed before and after oral drug treatment for a period of 28 wk. The study consisted of four randomized groups of subjects homogeneous for age, sex and life habits. The first group received a placebo, the second group received piracetam (1600 mg 3 times a day), the third group received pentoxifylline (400 mg 3 times a day), and the fourth group received a combination of piracetam and pentoxifylline. At the beginning and end of each phase of the study, neuropsychological and haemorheological parameters were evaluated in all subjects. The results show that the most evident improvement in psycho-intellectual performance, associated with an increase of whole blood filtration values, was obtained in the group treated with the two-drug combination.

Any of you guys have a chance to try this out?

[medievil]

Have you seen this thread on mind and muscle?

http://www.mindandmu...showtopic=42435

And the follow up:
http://www.mindandmu...showtopic=42566

Someone managed to abolish severe social anxiety by the use of pento with piracetam and memantine. (with the pento doing most of the work).

Edited by medievil, 27 July 2010 - 07:08 PM.

[FunkOdyssey]

Have you seen this thread on mind and muscle?
http://www.mindandmu...showtopic=42566

Someone managed to abolish severe social anxiety by the use of pento with piracetam and memantine. (with the pento doing most of the work).

You forgot baclofen, and I think baclofen was doing a large part of the work due to his serious concern about becoming tolerant to it.

Edited by FunkOdyssey, 27 July 2010 - 07:01 PM.

[medievil]

The baclofen only caused social reward, the pento completely abolished he's SA however he still was socially anhedonic, wich was fixed with what we think is the dopamine rebound caused by baclofen.

(I have him on MSN )

[FunkOdyssey]

The baclofen only caused social reward, the pento completely abolished he's SA however he still was socially anhedonic, wich was fixed with what we think is the dopamine rebound caused by baclofen.

(I have him on MSN )

Ahh, thanks for clarifying.

[zodiac]

The baclofen only caused social reward, the pento completely abolished he's SA however he still was socially anhedonic, wich was fixed with what we think is the dopamine rebound caused by baclofen.

(I have him on MSN )

hmm, very interesting...

[NG_F]

The baclofen only caused social reward, the pento completely abolished he's SA however he still was socially anhedonic, wich was fixed with what we think is the dopamine rebound caused by baclofen.

(I have him on MSN )

Medieveil can you please ask him when you get a chance as to how he discontinued or is discontinuing his alprazolam dosage.I posted in the forum and Pm'd him but sofar I didn't get a reply.

http://www.mindandmu...showtopic=42435 My handle is Nick430

I'm real interested to find out how quick he went about it because I have tried various med assisted taper's and have been unsuccessful.

Thanks, Much appreciated

[medievil]

He went cold turkey using memantine (wich reversed he's xanax tolerance for a big part) and topiramate:

Hum Psychopharmacol. 2003 Jul;18(5):375-7.
Topiramate in benzodiazepine withdrawal.
Cheseaux M, Monnat M, Zullino DF.

Policlinique Médicale Universitaire, Lausanne, Switzerland.
Abstract
There is an increasing interest in anticonvulsants for the treatment of benzodiazepine withdrawal symptoms. The new anticonvulsant compound topiramate seems to be an especially promising drug for this indication. It acts, among others, as an AMPA antagonist, which may be responsible in part for its anticonvulsant efficacy, but may also modulate the withdrawal-induced activation of noradrenergic neurons in the locus coeruleus, which are related to some behavioural effects of benzodiazepine withdrawal. A case is presented of a rapid benzodiazepine-withdrawal treated successfully with topiramate.

He needed to go up to 40mg of memantine i think before he saw a change in he's xanax tolerance.

Edited by medievil, 25 October 2010 - 03:39 PM.

[NG_F]

He went cold turkey using memantine (wich reversed he's xanax tolerance for a big part) and topiramate:

Hum Psychopharmacol. 2003 Jul;18(5):375-7.
Topiramate in benzodiazepine withdrawal.
Cheseaux M, Monnat M, Zullino DF.

Policlinique Médicale Universitaire, Lausanne, Switzerland.
Abstract
There is an increasing interest in anticonvulsants for the treatment of benzodiazepine withdrawal symptoms. The new anticonvulsant compound topiramate seems to be an especially promising drug for this indication. It acts, among others, as an AMPA antagonist, which may be responsible in part for its anticonvulsant efficacy, but may also modulate the withdrawal-induced activation of noradrenergic neurons in the locus coeruleus, which are related to some behavioural effects of benzodiazepine withdrawal. A case is presented of a rapid benzodiazepine-withdrawal treated successfully with topiramate.

He needed to go up to 40mg of memantine i think before he saw a change in he's xanax tolerance.

Thanks very much for this info and the abstract/citation you posted.Did he titrate the memantine dose to 40mgs first before adding in the topirimate or was it simultaneously done.Also can you find out as to which dosage of topimax(topiramate) he was using and found to alleviate immediate withdrawal and possibly protracted withdrawal symptoms?

It's very intersting and noteworthy that this type of medication(topirimate) would be very efficacious as the dual action of lowering glutumate combined with the memantine and also controlling to a degree the norepinephrine firing in the locus coeruleus which largely contributes to the severe anxiety,tachycardia and BP increases seen in benzodiazepine discontinuation.

Thanks Once again.

[medievil]

He was on memantine a while before that, i'l ask him everything when he shows up online.

[NG_F]

He was on memantine a while before that, i'l ask him everything when he shows up online.

Thanks medievil