21 replies to this topic

[FedAce]

Ok i used to take the micronized Resveratrol about 1 year ago but stopped because i thought it was causing my JOINT pains. Not 100% sure but i thought it was due to the drug not excersize i routinely do. I will list Joint pain . this is pretty serious stuff. but I really LOVE the zolt of Energy and stamina i can get from this drug. so I bought some again but this time from GNC,,,,they came out with brand new Chew and swallow grape flavored Resveratrol. Great Taste,,,,so i started taking it again 5 days ago. so far so good. LOVE that zolt of energy right after i take it. BETTER than Coffee.,,,,,,much better. I hope the Joint pain stays away.

Please list all your side effect you have personally experienced. I would be real interested. This is supposed to Cure Alzeimer's , Cancer, and make you younger by 10 years or so. Once it is approved by FDA as prescription,,,,,it will be a HOT drug. ONLY if it doesn't have some real bad side effects that is......................

Edited by FedAce, 01 August 2010 - 02:09 AM.

[2tender]

Insomnia, if taken after 10 am.

[shadowhawk]

none.

[Anthony_Loera]

No joint problems. In the beginning I did stay up at night a few times, but then it appeared to regulate my sleep, and provided deep sleep with vivid dreams.

I started with 2000mg daily, in the evening first using 50% pure resveratrol for 6-8 months, then switched to 2000mg of 98%.
Started on October of 2006.

My first 6 months:
==================================
After 30 days:
Higher aerobic stamina.
Better mental outlook.

After 2 months:
Noticeably less stress.
Better concentration.
Mild loss in weight, but it could have been attributed to me being more active.
People noticed my appearance changed, nail growth, skin change, hair thickness I suppose. But those were comments from folks around me, I didn't really notice these things.

After 6 months:
Definitely not a placebo effect after all this time, as it continued to provide a good mental feeling of well being.
Same as month 2, however I did notice a consistent injury from falling off a bicycle years back, did not bother me anymore.
==================================

In 2008 I had blood tests, and found out it didn't help cholesterol, but the rest of my work up was great.

Now in 2010, I am taking about 500mg or more of micronized resveratrol while I am not cycling with cycloastragenol, and at rare times I take some of my special nano-sized resveratrol we made a while back while investigating nano-res production (which turned out to be quite expensive). I suppose I am one of the few people with access to dry nano-resveratrol, but I mostly use it as as inspiration as it looks quite interesting when you move the jar with the nano particles and it flows around the jar in a liquid like fashion for a little bit, even though it's completely dry powder... kinda looks like I am holding a cloud in a jar when I do it... kind of neat really.


Anyway, at 39 years old I completely recommend it, even though I am a bit biased as we manufacture it ourselves.

Cheers
A

Edited by Anthony_Loera, 18 August 2010 - 01:49 AM.

[2tender]

Im more than glad to hear that you have had results similar to mine. As a young senior citizen that is health conscious, I think that Resveratrol is a great addition to anyones regimen, provided its tolerated and used in the purest, micronized form available. As we age supplements and exercise, can make a major difference in the way we look and feel..

[elphaba]

Joint pain - have reduced my dosage to 500 from 1K (micronized- Revgenetics) and still have joint pain but not so bad - have added more glucosamine, Vitamin D and more recently noni-juice - pain is tolerable but definitely I have more of it when I take resveratrol. I have a diagnosis of osteoarthritis prior to taking reveratrol but the resveratrol seems to exacerbate.

I started giving it to my geriatric Dog who has hip dysplasia but otherwise is in pretty good shape. Hoping to keep him alive as long as possible and at the time, I was doubting the resveratrol was significantly responsible for increasing my joint pain (otherwise I wouldn't have given it to him). After he started taking the resveratrol, the hip dysplasia got much much worse. So had to remove it from his regimen. Once removed, his hip dysplasia is back to where it was previously, bad but tolerable and he is still able to go for walks. When on the resveratrol regimen, we had to suspend his walks it was so bad. Can't be a placebo effect going on there.

(For anyone interested, I was surprised to find out that he really got a nice bounce from the noni-juice - though getting it down him is a real hassle. Have backed off and started giving him the capsules instead of liquid- either the initial bounce has worn off either way or the capsules just aren't as good because he's back to where he was, oh well.)

On the good side, resveratrol has reduced some benign cysts I had on my scalp from large marble size to almost nothing. And virtually eliminated the gingivitus(sp?) I had that I was having trouble keeping at bay. Also, has helped ease some low-grade chronic depression for me.

[maxwatt]

(see above)

How much vitamin D are you taking? Is it D3? Dry or oil-flled cap? Do you know your 25-hydroxy D serum level? Have you had it tested? Vitamin D did not help when I developed joint pain, until I increased my dose sufficiently to raise m blood serum levels to around 40; anything less than 30 is considered a clinical deficiency.

[bixbyte]

I have taken RESVERATROL for about 6 years.
But the original available Res was 20% pure and sold by Paradise Herbs.
So, I might be able to state that I have supplemented on the better Q Res maybe for 3 years plus or minus a couple months.
My wife decided to take Res after she read my blood tests results were generally improving slowly and my weight dropped very slowly.
Lost weight very slowly from near 200 to about 166 pounds
dose 1.5 grams per day of 98 and 99% Res

Side Effects: I take a small dose of lipitor 5 mg day
I think Res might modulate this medication

My brother passed away from a heart attack 4 years in Jan
Maybe Res could have helped him?

[elphaba]

(see above)

How much vitamin D are you taking? Is it D3? Dry or oil-flled cap? Do you know your 25-hydroxy D serum level? Have you had it tested? Vitamin D did not help when I developed joint pain, until I increased my dose sufficiently to raise m blood serum levels to around 40; anything less than 30 is considered a clinical deficiency.

I'm taking 1000 iu D3 gel caps - two per day - my blood serum is above 30, 32 if I remember correctly but not yet 40. Thanks for the info. I will increase my supplementation and hope to keep improving the blood serum level because the joint pain is quite uncomfortable - would be nice to know what life would be like with less of it - if there is a chance more D3 will do that, I'm in.

[maxwatt]

(see above)

How much vitamin D are you taking? Is it D3? Dry or oil-flled cap? Do you know your 25-hydroxy D serum level? Have you had it tested? Vitamin D did not help when I developed joint pain, until I increased my dose sufficiently to raise my blood serum levels to around 40; anything less than 30 is considered a clinical deficiency.

I'm taking 1000 iu D3 gel caps - two per day - my blood serum is above 30, 32 if I remember correctly but not yet 40. Thanks for the info. I will increase my supplementation and hope to keep improving the blood serum level because the joint pain is quite uncomfortable - would be nice to know what life would be like with less of it - if there is a chance more D3 will do that, I'm in.

Do you know what your blood level was before you began supplementing? If so it should be possible to calculate how much you need to get it above 40. Around 50 is the target I'd aim for. I'd get the level tested periodically. Even if you hit your target, your levels may continue to rise, and over 70 may be counter productive.

I hope this helps. Do let us know how it works out.

[Anthony_Loera]

One last thing...In my personal opinion..

When I first took it, it appeared like I was handling my baby boy's midnight crying a bit (when he was 1-2).
Tonight I took two grams about 2 hours ago, and I get the feeling it is helping me with other some other person's whining and crying in the middle of the night...


Do you guys find it relieves stress like I do? Of course, it could be all in my mind.

A

[2tender]

I have found that higher doses may have that effect. Thats primarily why I keep doses under 1 grm, preferably in the 250-500 mgs range. If I feel any build up I stop for a day or two. I much prefer the energizing, stamina enhancing effects that come about from regular, low to medium doses. One capsule of the pre-emulsified version alternated with the 500 mg, micronized powder, seems to be sufficient, anything over that does seem to have sedative properties, for me anyway. I wouldnt say its tranquilizing, but it does seem to inhibit any over reaction to stressful situations. I definately notice a difference if I havent used it for 3 or more days. Purely subjective, anecdotal and perhaps placebo, but still in my regimen for those reasons.

[geo12the]

I

Side Effects: I take a small dose of lipitor 5 mg day
I think Res might modulate this medication

Maybe Res could have helped him?

I have been curious about the interaction of resveratrol and drugs like Lipitor. Could you elaborate on what you mean by modulating this medication?

[FedAce]

I

Side Effects: I take a small dose of lipitor 5 mg day
I think Res might modulate this medication

Maybe Res could have helped him?

I have been curious about the interaction of resveratrol and drugs like Lipitor. Could you elaborate on what you mean by modulating this medication?

Usually this mean taht Lipitor will affect the metabolism of the RES. What Lipitor does with many other drugs like Cyclosporin is that it will inhibit Metabolism of the drug by the Liver so that you will have Higher level of the drug in your system.

[niner]

Side Effects: I take a small dose of lipitor 5 mg day
I think Res might modulate this medication

Maybe Res could have helped him?

I have been curious about the interaction of resveratrol and drugs like Lipitor. Could you elaborate on what you mean by modulating this medication?

Usually this mean taht Lipitor will affect the metabolism of the RES. What Lipitor does with many other drugs like Cyclosporin is that it will inhibit Metabolism of the drug by the Liver so that you will have Higher level of the drug in your system.

Lipitor (atorvastatin) is metabolized by CYP3A4, and resveratrol is a (not extremely potent) inhibitor of 3A4, so resveratrol might be expected to raise Lipitor levels, though not by a large amount. Relative to more potent 3A4 inhibitors like clarithromycin, azole antifungals, or some AIDS drugs, I don't think resveratrol is anything to write home about.

[FedAce]

Side Effects: I take a small dose of lipitor 5 mg day
I think Res might modulate this medication

Maybe Res could have helped him?

I have been curious about the interaction of resveratrol and drugs like Lipitor. Could you elaborate on what you mean by modulating this medication?

Usually this mean taht Lipitor will affect the metabolism of the RES. What Lipitor does with many other drugs like Cyclosporin is that it will inhibit Metabolism of the drug by the Liver so that you will have Higher level of the drug in your system.

Lipitor (atorvastatin) is metabolized by CYP3A4, and resveratrol is a (not extremely potent) inhibitor of 3A4, so resveratrol might be expected to raise Lipitor levels, though not by a large amount. Relative to more potent 3A4 inhibitors like clarithromycin, azole antifungals, or some AIDS drugs, I don't think resveratrol is anything to write home about.

Liitor itself is what we call Liver Enzyme Inducer. so lipitor also speeds up metabolism of other drugs

[niner]

Liitor itself is what we call Liver Enzyme Inducer. so lipitor also speeds up metabolism of other drugs

Generally speaking, any compound will induce the enzyme that metabolizes it, if you take enough of the compound. This is one of the ways that the body maintains homeostasis in all things. However, the degree of induction varies, and there really aren't that many compounds where it's high enough to be a problem. Also, There are on the order of a hundred different enzymes that participate in drug metabolism, and typically only one to four of them will be involved with any given compound. So even if there is induction, it will only affect the metabolism of drugs that are also metabolized by the same enzyme. From a quick search, I didn't see any evidence that Lipitor, at least in the doses normally used, is a significant inducer of anything, although you can find a lot of warnings about taking it with other drugs that are 3A4 inducers.

[farang]

Liitor itself is what we call Liver Enzyme Inducer. so lipitor also speeds up metabolism of other drugs

Generally speaking, any compound will induce the enzyme that metabolizes it, if you take enough of the compound. This is one of the ways that the body maintains homeostasis in all things. However, the degree of induction varies, and there really aren't that many compounds where it's high enough to be a problem. Also, There are on the order of a hundred different enzymes that participate in drug metabolism, and typically only one to four of them will be involved with any given compound. So even if there is induction, it will only affect the metabolism of drugs that are also metabolized by the same enzyme. From a quick search, I didn't see any evidence that Lipitor, at least in the doses normally used, is a significant inducer of anything, although you can find a lot of warnings about taking it with other drugs that are 3A4 inducers.

Lipitor is maybe good and useful for some individuals with high cholesterol. Personally though, I suffered severe side effects from Crestor which is somewhat similar to Lipitor. I developed peripheral neuropathy which I never experienced before, and I have not completely recovered after one year, though I feel better. Thus, I advise people to be careful with statins in case they develop side effects.

[FedAce]

Liitor itself is what we call Liver Enzyme Inducer. so lipitor also speeds up metabolism of other drugs

Generally speaking, any compound will induce the enzyme that metabolizes it, if you take enough of the compound. This is one of the ways that the body maintains homeostasis in all things. However, the degree of induction varies, and there really aren't that many compounds where it's high enough to be a problem. Also, There are on the order of a hundred different enzymes that participate in drug metabolism, and typically only one to four of them will be involved with any given compound. So even if there is induction, it will only affect the metabolism of drugs that are also metabolized by the same enzyme. From a quick search, I didn't see any evidence that Lipitor, at least in the doses normally used, is a significant inducer of anything, although you can find a lot of warnings about taking it with other drugs that are 3A4 inducers.

Lipitor is maybe good and useful for some individuals with high cholesterol. Personally though, I suffered severe side effects from Crestor which is somewhat similar to Lipitor. I developed peripheral neuropathy which I never experienced before, and I have not completely recovered after one year, though I feel better. Thus, I advise people to be careful with statins in case they develop side effects.

Interesting. because Crestor is the drug that was used in Landmark study called Jupiter study. Cretor lowered Mortality in patients with high LDL and showed tremendous benefit. Peripheral neuropathy is actually rare side effect. Myopathy and liver dysfuction is more common with statins. I am a pharmaceutical research scientist so i know.

[bixbyte]

Interesting. because Crestor is the drug that was used in Landmark study called Jupiter study. Cretor lowered Mortality in patients with high LDL and showed tremendous benefit. Peripheral neuropathy is actually rare side effect. Myopathy and liver dysfuction is more common with statins. I am a pharmaceutical research scientist so i know.

Crestor a drug in the statin family lowered mortality by decreasing C-reactive protein. Laymans terms, Statins have the ability to lower pain in your blood vessels.
In addition statins lower cholesterol.


Peripheral Neuropathy is a side effect noted by patients dosing on Lipitor and I believe the FDA boiler plated this warning to all statin medications.

I am not an expert just an observer of many people with heart disease.

[FedAce]

Interesting. because Crestor is the drug that was used in Landmark study called Jupiter study. Cretor lowered Mortality in patients with high LDL and showed tremendous benefit. Peripheral neuropathy is actually rare side effect. Myopathy and liver dysfuction is more common with statins. I am a pharmaceutical research scientist so i know.

Crestor a drug in the statin family lowered mortality by decreasing C-reactive protein. Laymans terms, Statins have the ability to lower pain in your blood vessels.
In addition statins lower cholesterol.


Peripheral Neuropathy is a side effect noted by patients dosing on Lipitor and I believe the FDA boiler plated this warning to all statin medications.

I am not an expert just an observer of many people with heart disease.

C-reactive protein is a MARKER that the Jupiter study used to separate out patients and use as the Inclusion criteria. Patients with high C-reactive protein has higher risk of experiencing MI or heart attack. and ??????Lower Pain in blood vessels,,,wow,,,that is not a Layman's term,,,that is PURE ingnorance. Heart attack happens from plaques forming in the vital arteries and causing blockage and these plaques can break open and release clotting factors which adds to the damage. and YES, periphral neuropathy is a side effect and it is RARE. Foundation and Goal of preventing heart attack by using statins like Crestors is to lower LDL and serum Cholesterol. and hopefully raise HDL in the process.

[munkeegutz]

Interesting. because Crestor is the drug that was used in Landmark study called Jupiter study. Cretor lowered Mortality in patients with high LDL and showed tremendous benefit. Peripheral neuropathy is actually rare side effect. Myopathy and liver dysfuction is more common with statins. I am a pharmaceutical research scientist so i know.

Crestor a drug in the statin family lowered mortality by decreasing C-reactive protein. Laymans terms, Statins have the ability to lower pain in your blood vessels.
In addition statins lower cholesterol.


Peripheral Neuropathy is a side effect noted by patients dosing on Lipitor and I believe the FDA boiler plated this warning to all statin medications.

I am not an expert just an observer of many people with heart disease.

C-reactive protein is a MARKER that the Jupiter study used to separate out patients and use as the Inclusion criteria. Patients with high C-reactive protein has higher risk of experiencing MI or heart attack. and ??????Lower Pain in blood vessels,,,wow,,,that is not a Layman's term,,,that is PURE ingnorance. Heart attack happens from plaques forming in the vital arteries and causing blockage and these plaques can break open and release clotting factors which adds to the damage. and YES, periphral neuropathy is a side effect and it is RARE. Foundation and Goal of preventing heart attack by using statins like Crestors is to lower LDL and serum Cholesterol. and hopefully raise HDL in the process.

My father is an Anesthesiologist at a major hospital in Florida: while he is not personally an expert in this particular field, he has several cardiologist friends who are. An overwhelming number of them take statins, as does my father, and so will I once I turn about 30-33.