3 replies to this topic

[madanthony]

DOes anyone have any information about these types of mutations?
Here is the thing - 5 years ago I had an hcy value of 8, last year 12, this year
after taking this protocol, 6.1: 5g MB12 (Jarrow sublingual -1-2/day), P5P (Country Life), Methylfolate (Solgar, maybe), 2G. TMG (Soloray), B-Right (active B's - 2x/day). P.S. I eat an egg every day of my life, always did, and all my life took a B100 complex. I also take garlic and broccoli pills (sulfur) as of the last year.

The question is -- the way I understand it, CBS mutations should cause LOW homocysteine, how could mine be high? And also, Dr. Yasko seems to think CBS C699T is the autism gene...well, here I am blabbing away, how could I be autistic? I guess I should add a more pertinent question -- any suggestions of what should be done to mitigate such genes? Thanks

[MoodyBlue]

I know nothing about your types of polymorphisms, but the following might bring down your homocysteine levels to normal unless there are other causes of elevated homocysteine levels which I don't know about.The information I'm going to give you is from the book, "Fantastic Voyage, Live Long Enough to Live Forever", by Ray Kurzweil and Terry Grossman, M.D.. It was a gift to me and I believe all Imminst members around 4 or 5 years ago.

If your homocysteine levels are too high it is probably because you have an MTHFR polymorphism. This enzyme is needed to change homocysteine back into methionine. One of the most common polymorphisms (genetic variants) in the human population is a genetic variation of this enzyme -- the so called MTHFR 677→T polymorphism. (This means that the 677th nucleotide in the gene that codes for homocysteine is replaced by thymidine.) The 677 C→T polymorphism is quite common. Up to 44 percent of the Caucasian and Asian populations have at least one copy of this mutated gene. Whereas a single copy of the mutated gene rarely causes elevated homocysteine levels by itself, approximately 12 of Caucasians and Asians are homozygous, meaning they have two copies of the polymorphism. Without aggresive nutritional treatment, these individuals often have elevated homocyseine levels. Luckily, it appears that in most cases the harmful effects of this genetics variant can be corrected by taking adequate amounts of nutritional supplements.

Here is a list of the nutrients needed which are useful in lowering homocysteine:

B12 -- 100-2000 mcg
Folic Acid -- 800-10,000 mcg
Vitamin B2 -- 25-100 mg
Vitamin B6 -- 50-100 mg
Betaine Hcl -- 100-300 mg
Zinc -- 15-50 mg
Magnesium -- 400-800 mg
Betaine Anhydrous -- 50-3000 mg

If you have the MTHFR mutation then taking high amounts of Folic Acid will lead to Folic Acid toxicity because the MTHFR enzyme is needed to convert Folic Acid into its activated form which is Methylfolate. Methylfolate is available as a supplement. I would take RDA or less amounts of Folic Acid with Methylfolate. The Betaine Anhydrous is indispensable because it is an excellent methyl donor and homocysteine is converted back to methionine via the methylation process. A genomics test can identify whether or not you have a MTHFR polymorphism.

[madanthony]

I know nothing about your types of polymorphisms, but the following might bring down your homocysteine levels to normal unless there are other causes of elevated homocysteine levels which I don't know about.The information I'm going to give you is from the book, "Fantastic Voyage, Live Long Enough to Live Forever", by Ray Kurzweil and Terry Grossman, M.D.. It was a gift to me and I believe all Imminst members around 4 or 5 years ago.

If your homocysteine levels are too high it is probably because you have an MTHFR polymorphism. This enzyme is needed to change homocysteine back into methionine. One of the most common polymorphisms (genetic variants) in the human population is a genetic variation of this enzyme -- the so called MTHFR 677→T polymorphism. (This means that the 677th nucleotide in the gene that codes for homocysteine is replaced by thymidine.) The 677 C→T polymorphism is quite common. Up to 44 percent of the Caucasian and Asian populations have at least one copy of this mutated gene. Whereas a single copy of the mutated gene rarely causes elevated homocysteine levels by itself, approximately 12 of Caucasians and Asians are homozygous, meaning they have two copies of the polymorphism. Without aggresive nutritional treatment, these individuals often have elevated homocyseine levels. Luckily, it appears that in most cases the harmful effects of this genetics variant can be corrected by taking adequate amounts of nutritional supplements.

Here is a list of the nutrients needed which are useful in lowering homocysteine:

B12 -- 100-2000 mcg
Folic Acid -- 800-10,000 mcg
Vitamin B2 -- 25-100 mg
Vitamin B6 -- 50-100 mg
Betaine Hcl -- 100-300 mg
Zinc -- 15-50 mg
Magnesium -- 400-800 mg
Betaine Anhydrous -- 50-3000 mg

If you have the MTHFR mutation then taking high amounts of Folic Acid will lead to Folic Acid toxicity because the MTHFR enzyme is needed to convert Folic Acid into its activated form which is Methylfolate. Methylfolate is available as a supplement. I would take RDA or less amounts of Folic Acid with Methylfolate. The Betaine Anhydrous is indispensable because it is an excellent methyl donor and homocysteine is converted back to methionine via the methylation process. A genomics test can identify whether or not you have a MTHFR polymorphism.

Thank you. I do not know why my genetic mutations did not print. I do not have the MTHFR C677T gene, I have the MTHFR 1298 gene, which is used to replenish BH4. I have 18 mutations out of the 30 checked for at the www.heartfixers.com (Dr. Roberts/Yasko site), including CBS +/+, COMT +/+, all VDR +/+, all AHCY, two BHMT, MTR, ACE, MTHFR 1298, -- everyt6hing but SUOX (so I am not allergic to shellfish). Estrogen provides a sneak path around most of these problems - don't know how, but I have no problem except at PMS. I have found that estrogen protects against glutamate toxicity. I have lowered my homocysteine to normal, but it took specialized pills as I stated in my original post. I just wondered if anyone else had tested their genetics and could say anything about CBS and how it could be possible to have high homocysteine when high CBS activity drains it away. Thanks

[MoodyBlue]

Here is a website with some nutritional and supplementation guidelines for various genetic mutations, including many of yours: http://www.heartfixe...ethyl Cycle.htm. There are 3 types of MTHFR 1298 mutations (A1298C, 1298AA, 1298CC,) of which A1298C is the most common. It result ins slowed metabolism of methyfolate (that might be the reason fo higher homocysteine. Here's a website which has some info on that: http://www.detoxpuzzle.com/mthfr.php. I've read that Rhodiola Rosea is excellent for the menstrual cycle in various ways. Research it, and you might try and benefit from it.