From http://www.scienceda...00915100935.htm :
Fountain of Youth in Bile? Longevity Molecule Identified
ScienceDaily (Sep. 15, 2010) — The human quest for longer life may be one step closer, thanks to research from Concordia University. Published in the journal Aging, a new study is the first to identify the role of a bile acid, called lithocholic acid (LCA), in extending the lifespan of normally aging yeast. The findings may have significant implications for human longevity and health, as yeast share some common elements with people.
"Although we found that LCA greatly extends yeast longevity, yeast do not synthesize this or any other bile acid found in mammals," says senior author Vladimir Titorenko, Concordia University Research Chair in Genomics, Cell Biology and Aging and a professor in the Department of Biology. "It may be that yeast have evolved to sense bile acids as mildly toxic molecules and respond by undergoing life-extending changes. It is conceivable that the life-extending potential of LCA may be relevant to humans as well."
Over 19,000 small molecules screened
Titorenko and colleagues screened more than 19,000 small molecules to test their ability to extend yeast-lifespan. Under both normal and stressed conditions, LCA had a major impact.
"Our findings imply that LCA extends longevity by targeting two different mechanisms," says first author Alexander Goldberg, a Concordia doctoral student. "The first takes place regardless of the number of calories and involves the day-to-day or housekeeping proteins. The second system occurs during calorie-restriction and involves stressor proteins."
"Regardless of their triggers both of these mechanisms work to suppress the pro-aging process," he continues.
Bile acids may be beneficial to health
"Although we have an overall idea how LCA works to extend longevity in yeast, we still need to determine if this is the case for other species," says Titorenko. "We do know from previous studies, however, that bile acids are beneficial to health and longevity. For example, they have shown to accumulate in the serum of long living mice and play a role in improving rodent liver and pancreatic function."
"This leads us to believe that bile acids have potential as pharmaceutical agents for the treatment of diabetes, obesity and various metabolic disorders, all of which are age-related," continues Titorenko. "They may indeed offer hope for a healthy aging life."
This study was funded by the Canadian Institutes of Health Research, the Natural Sciences and Engineering Research Council of Canada, the Canada Foundation for Innovation and the Concordia University Chair Fund.
Interestingly, Wikipedia seems to have very little good to say about lithocholic acid:
Lithocholic acid is a bile acid that acts as a detergent to solubilize fats for absorption. It is made from chenodeoxycholic acid by bacterial action in the colon. It has been implicated in human and experimental animal carcinogenesis.[2] Dietary fiber can bind to lithocholic acid and aid in its excretion in stool[3]; as such, fiber can protect against colon cancer.
References
1. ^ Lithocholic acid at Sigma-Aldrich
2. ^ http://carcin.oxford...t/full/21/5/999
3. ^ http://content.nejm....ull/329/1/21/F2
Also, this from http://www.phaster.c...and_cancer.html :
“Lithocholic acid is highly toxic, and it builds up in a high-fat diet,” Mangelsdorf said. “We don’t know how it causes cancer; but it is known to cause cancer in mice, and people with colon cancer have high concentrations of it.”
Scientists knew that a certain receptor controlled the small amount of lithocholic acid in the liver. Receptors are proteins that bind to certain substances to help the body absorb or get rid of them. The lithocholic acid-controlling receptor also is present in the colon. But there isn’t enough of it to cope with large volumes of lithocholic acid.
Edited by resveratrol, 15 September 2010 - 11:46 PM.
