3 replies to this topic

[Neuronic]

I can only find studies done on animals and I would like to know what kind of results have come from treating narcoleptics with Orexin supplements.
I want to talk to my Dr about it but I want to be sure it's safe... not develop Alzheimers in the near future.

If anyone is better than me at finding case studies/ trials pertaining to this I would appreciate a link.
Especially concerning it's effects on memory(working,short,long-term) and attention.

[chrono]

I reviewed the abstracts on orexin last week, and just did a focused search on narcolepsy, and didn't see any human trials per se. As you say, there are studies in rats and dogs, and some studies showing that human narcoleptics have an 85%+ loss of function in the orexin system. The possibility of human use seems to be extrapolated from this data. The full texts of some of the newest review articles might have some tidbits, but as far as I can tell, hypocretin replacement therapy isn't available yet as a treatment. Though someone mentioned here recently that they knew someone who was taking it, but details were lacking.

If this is the same doctor who dismissed your use of piracetam and deprenyl as reckless, I don't think there's any realistic possibility that he's going to prescribe you a largely experimental, preclinical therapy. Have you looked into other newer treatments, like histamine agonists?

Edited by chrono, 18 September 2010 - 02:40 AM.

[Ark]

I reviewed the abstracts on orexin last week, and just did a focused search on narcolepsy, and didn't see any human trials per se. As you say, there are studies in rats and dogs, and some studies showing that human narcoleptics have an 85%+ loss of function in the orexin system. The possibility of human use seems to be extrapolated from this data. The full texts of some of the newest review articles might have some tidbits, but as far as I can tell, hypocretin replacement therapy isn't available yet as a treatment. Though someone mentioned here recently that they knew someone who was taking it, but details were lacking.

If this is the same doctor who dismissed your use of piracetam and deprenyl as reckless, I don't think there's any realistic possibility that he's going to prescribe you a largely experimental, preclinical therapy. Have you looked into other newer treatments, like histamine agonists?

Your post inspired me to suggest a new forum : trails and clinical updates !?


I wonder how sleep patterns effect production of orexin after supplementation or the effectiveness of Orexin on healthy subjects.(longtemr)

[NR2(x)]

Unpatentable and performance enhancing therefore will not happen....if it caught on it would become illegal.
Gene therapy and peptides have been big in sports doping for five to ten years now, so imagine that orexins have been trailed, as it would be a good candidate. I would do a short term trial if i had pharmakenetics and product. Long term there is the need to balance out the beta-amyliod enducing effects, GM-CSF is a protien that could achieve this, with other positve side-effects and is approved to in vivo human disease. Also there are drugs(nmda antagonist) that increase "Long term depression", which would decrease the formation of beta-amyliod