15 replies to this topic

[N.T.M.]

In one of the books I read recently there was a quick mention of benfotiamine’s efficacy as an anti-glycator being supported by in vivo testing (apparently unlike most tests which are isolated to test tubes). Later I ran a quick google search and that seems to be accurate. So, my question here is what is the optimal daily dose? I know that, for example, B6 in excess can negatively affect cognition. Right now I’m taking just 100 mg/day. Can I take more?

Thanks in advance.

-Nick

[triplecrown]

In one of the books I read recently there was a quick mention of benfotiamine’s efficacy as an anti-glycator being supported by in vivo testing (apparently unlike most tests which are isolated to test tubes). Later I ran a quick google search and that seems to be accurate. So, my question here is what is the optimal daily dose? I know that, for example, B6 in excess can negatively affect cognition. Right now I’m taking just 100 mg/day. Can I take more?

Thanks in advance.

-Nick

don't use it
http://www.imminst.o...ncer-risk-quit/

Edited by triplecrown, 12 October 2010 - 08:04 AM.

[pycnogenol]

I take benfotiamine daily and am glad I do; I take 250 mg twice per day (500 mg total) for glucose management. Works for me.

Edited by pycnogenol, 12 October 2010 - 03:22 PM.

[KimberCT]

I took 500mg per day for a few months and then reduced to 250mg per day for maintenance.  Using it for neuropathy.

[mikeinnaples]

In one of the books I read recently there was a quick mention of benfotiamine’s efficacy as an anti-glycator being supported by in vivo testing (apparently unlike most tests which are isolated to test tubes). Later I ran a quick google search and that seems to be accurate. So, my question here is what is the optimal daily dose? I know that, for example, B6 in excess can negatively affect cognition. Right now I’m taking just 100 mg/day. Can I take more?

Thanks in advance.

-Nick

don't use it
http://www.imminst.o...ncer-risk-quit/

Yes, read that thread. The conclusion though is hardly 'don't use it'. Make your own decision.

[N.T.M.]

In one of the books I read recently there was a quick mention of benfotiamine’s efficacy as an anti-glycator being supported by in vivo testing (apparently unlike most tests which are isolated to test tubes). Later I ran a quick google search and that seems to be accurate. So, my question here is what is the optimal daily dose? I know that, for example, B6 in excess can negatively affect cognition. Right now I’m taking just 100 mg/day. Can I take more?

Thanks in advance.

-Nick

don't use it
http://www.imminst.o...ncer-risk-quit/

Yes, read that thread. The conclusion though is hardly 'don't use it'. Make your own decision.

Sounds a bit reminiscent of the ever-so-common B9 critique. Since B9 aids in nucleotide synthesis, it helps repair DNA damage. And, of course, it also supports excessive cell proliferation, like in cancer. Still though, that doesn’t sound like a valid reason for not taking it. In fact (from what I’ve read), DNA repair via folic acid actually helps prevent cancer. My point is just that the benfotiamine criticism sounds very similar.

I think I’ll try 500 mg/day.

[mikeinnaples]

At that dose expect your sweat and urine to smell funky. Heh

On a side note, given the half life of Benfotiamine, I was never able to justify taking over 100mg / day.

[pycnogenol]

At that dose expect your sweat and urine to smell funky. Heh

On a side note, given the half life of Benfotiamine, I was never able to justify taking over 100 mg / day.

I've never had the "funky urine/sweat smell" from benfotiamine so I guess I'm real fortunate.

[TheFountain]

I took benfotiamine for a few months last year (300 mgs a day) in conjunction with taurine for glycation inhibition. I am not exactly sure why but I stopped taking it. I guess this happened around the time I began taking L-carnosine. I just slowly stopped the benfotiamine and instinctively favored the L-carnosine. I have been considering re-introducing Benfotiamine back into my regimen, but I am not sure if or when or if there is a point to it when I am already taking L-carnosine and Taurine. It just seems like anti-glycation overkill to take it in addition to the other's.

Edited by TheFountain, 19 December 2010 - 05:23 PM.

[mikeinnaples]

I took benfotiamine for a few months last year (300 mgs a day) in conjunction with taurine for glycation inhibition. I am not exactly sure why but I stopped taking it. I guess this happened around the time I began taking L-carnosine. I just slowly stopped the benfotiamine and instinctively favored the L-carnosine. I have been considering re-introducing Benfotiamine back into my regimen, but I am not sure if or when or if there is a point to it when I am already taking L-carnosine and Taurine. It just seems like anti-glycation overkill to take it in addition to the other's.

Well I am not so sure there is such a thing as overkill with anti-glycation... but yeah, i understand what you mean.

[poolboy]

In this study, the human dose equivalent would be about 2000 mg per day of Benfotiamine for a 70K human.

Higher dose was better protection against Alzheimer's than 1000 mg or 500 mg human equivalent.

I think we are going to find the optimal dose for antiaging purposes is a lot higher than anyone here is taking.

' class='bbc_url' title='External link' rel='nofollow external'>http://brain.oxfordjournals.org/content/133/5/1342.full.pdf'] Powerful beneficial effects of benfotiamine on cognitive impairment and b-amyloid deposition in amyloid precursor protein/presenilin-1 transgenic mice
"These results suggest that, unlike many other thiamine-related drugs, benfotiamine may be beneficial for clinical Alzheimer’s disease treatment."

→ source (external link)

Edited by poolboy, 24 April 2012 - 11:45 PM.

[APBT]

In this study, the human dose equivalent would be about 2000 mg per day of Benfotiamine for a 70K human.

Higher dose was better protection against Alzheimer's than 1000 mg or 500 mg human equivalent.

I think we are going to find the optimal dose for antiaging purposes is a lot higher than anyone here is taking.

' class='bbc_url' title='External link' rel='nofollow external'>http://brain.oxfordjournals.org/content/133/5/1342.full.pdf'] Powerful beneficial effects of benfotiamine on cognitive impairment and b-amyloid deposition in amyloid precursor protein/presenilin-1 transgenic mice
"These results suggest that, unlike many other thiamine-related drugs, benfotiamine may be beneficial for clinical Alzheimer’s disease treatment."

→ source (external link)

There is this study that seems contradict, or call into question those results.

Conclusion

Our results show that, though benfotiamine strongly increases thiamine levels in blood and liver, it has no significant effect in the brain. This would explain why beneficial effects of benfotiamine have only been observed in peripheral tissues, while sulbutiamine, a lipid-soluble thiamine disulfide derivative, that increases thiamine derivatives in the brain as well as in cultured cells, acts as a central nervous system drug. We propose that benfotiamine only penetrates the cells after dephosphorylation by intestinal alkaline phosphatases. It then enters the bloodstream as S-benzoylthiamine that is converted to thiamine in erythrocytes and in the liver. Benfotiamine, an S-acyl derivative practically insoluble in organic solvents, should therefore be differentiated from truly lipid-soluble thiamine disulfide derivatives (allithiamine and the synthetic sulbutiamine and fursultiamine) with a different mechanism of absorption and different pharmacological properties.
http://www.biomedcen.../1471-2210/8/10

[poolboy]

In this study, the human dose equivalent would be about 2000 mg per day of Benfotiamine for a 70K human.

Higher dose was better protection against Alzheimer's than 1000 mg or 500 mg human equivalent.

I think we are going to find the optimal dose for antiaging purposes is a lot higher than anyone here is taking.

' class='bbc_url' title='External link' rel='nofollow external'>http://brain.oxfordjournals.org/content/133/5/1342.full.pdf'] Powerful beneficial effects of benfotiamine on cognitive impairment and b-amyloid deposition in amyloid precursor protein/presenilin-1 transgenic mice
"These results suggest that, unlike many other thiamine-related drugs, benfotiamine may be beneficial for clinical Alzheimer’s disease treatment."

→ source (external link)

There is this study that seems contradict, or call into question those results.

Conclusion

Our results show that, though benfotiamine strongly increases thiamine levels in blood and liver, it has no significant effect in the brain. This would explain why beneficial effects of benfotiamine have only been observed in peripheral tissues, while sulbutiamine, a lipid-soluble thiamine disulfide derivative, that increases thiamine derivatives in the brain as well as in cultured cells, acts as a central nervous system drug. We propose that benfotiamine only penetrates the cells after dephosphorylation by intestinal alkaline phosphatases. It then enters the bloodstream as S-benzoylthiamine that is converted to thiamine in erythrocytes and in the liver. Benfotiamine, an S-acyl derivative practically insoluble in organic solvents, should therefore be differentiated from truly lipid-soluble thiamine disulfide derivatives (allithiamine and the synthetic sulbutiamine and fursultiamine) with a different mechanism of absorption and different pharmacological properties.
http://www.biomedcen.../1471-2210/8/10

The study I quoted was a much longer study -- 8 weeks.. Look at the charts -- it clearly changed the amount of plaque in the brain and increased the spacial memory of the mice in a water maze. Not sure what happened in the study you quote, but clearly benfotiamine changes brain metabolism.

[mikeinnaples]

Interesting.

Edited by mikeinnaples, 25 April 2012 - 12:25 PM.

[APBT]

The study I quoted was a much longer study -- 8 weeks.. Look at the charts -- it clearly changed the amount of plaque in the brain and increased the spacial memory of the mice in a water maze. Not sure what happened in the study you quote, but clearly benfotiamine changes brain metabolism.

Yeah, I don't know why, but there appears to be conflicting results between these two studies.
Do you currently use benfotiamine? If so, what is your dosing amount and schedule? Do you have a preferred source of benfotiamine?

[ta5]

Life Extension is now recommending up to 1000mg/day of Benfotiamine.

Benfotiamine And Glycation - Life Extension

Protect Your Cells from Sugar Damage - Life Extension

 

Based on this study that used 1050mg/day for 3 days.

Stirban A, Negrean M, Stratmann B, et al. Benfotiamine prevents macro- and microvascular endothelial dysfunction and oxidative stress following a meal rich in advanced glycation end products in individuals with type 2 diabetes. Diabetes Care. 2006 Sep;29(9):2064-71.

 

3 days doesn't seem like very long. Does anyone else here have experience with doses that high?