155 replies to this topic

[medievil]

Update 2010-10-27
--------------------

Problems i'm trying to fix: severe ADHD, OCD and social anxiety:

Currently im taking:

60 mg memantine
8 mg candesartan
3x 600mg of NAC

Still on a break of everything else, soon will readd:
7,5 mg alpha methyl tryptamine
5mg nebivilol (ran out)
3x 5mg dexedrine
Nicotine
Galantamine
Selank
Piracetam
Alcar
Resveratrol
Curcumin

I have a bad cold and wont restart the amt or amp untill i'm fully recovered, stopped taking them last thursday, will probably make this a weekbreak.

Old post:

Problems i'm trying to fix: severe ADHD, OCD and social anxiety:

80mg memantine at this point to see wheter it can actively reverse tolerance while staying at certain substances, also memantine works wonders for my OCD.

AMT: A selective dopamine and serotonine releasing agent, it dramatically improves my condition with far less euphoria of dexedrine (too much euphoria is counterproductive and keeps me inside)/

Dexedrine, because AMT still doesnt fix up mu avoidant behavor, i need a small boost, however dex added to AMT causes way too much euphoria and way too much anxiety.

20 gram piracetam, temporary experiment to see wheter there's some merit to it.
2 gram alcar a day
16mg galantamine a day.
5 mg Nebivolol
8 mg Candesartan

Last 2 i'm trying to counteract the amp anxiety, at this moment AMT and amp are still being inhibited probably because of the memantine adaptation phase, i'm trying to maximize the therapeutic effects and block the euphoria and anxiety.

Being euphoric all day long is fun, but its not the life i want, i want to be free of SA and be outside with my friends all the time, so blocking the counterproductive amp euphoria is a must for me too.

Well see

Edited by medievil, 27 October 2010 - 08:31 PM.

[aLurker]

Cool to see you have a regimen-thread here now. You might want to list what you've already tried and how you responded to it since that should help. I can't help feeling that list might be very long though :p

[medievil]

Cool to see you have a regimen-thread here now. You might want to list what you've already tried and how you responded to it since that should help. I can't help feeling that list might be very long though :p

Yeah i'l come up with a list later, also will explain why i beleive amphetamine or AMT are absolutely essential for my SA and that i'm not trying to chase euphoria.

[medievil]

Do you guys think low dose naltrexone at night has any merrit in improving my condition?

[aLurker]

Do you guys think low dose naltrexone at night has any merrit in improving my condition?

Probably not (unless your social issues are due to autism). Could with help the anxiety though. Beware of the memantine with naltrexone though (as I've mentioned earlier). That much memantine seems kind of excessive considering that the usual dosage is 20 mg per day. MOAR isn't always better, even if you're taking it for tolerance.

Are you exploring any other paths towards easing your condition such as any psychological routes?

[medievil]

My physiological issues are 100% fixed up now, they werent in the past but due to alot of things that happened i have now confidence, social skills etc, i also dont worry about what ppl would think of me or any of that rubbish hence why GHB, benzo's and alcohol dont work for (things that generall add to your "confidence" by making you not care, but i dont care in the first place.

I beleive my SA stems from my severe ADHD.

[aLurker]

Great to hear that you've made progress. No matter what the cause of your SA or ADHD is I still think you could combine your medical regimen with some kind of psychological route, like meditation or CBT for instance. I can see why you would think this is a waste of time right now and I fully sympathize with you since I'm kind of impatient myself yet there is no denying that for example meditation has a lot of scientific support and should eventually lead to sustainable improvements which in the long run. I'm all for medication and I think the combination of medication and something more therapeutic is far better than either one alone.

Edited by aLurker, 14 October 2010 - 08:22 PM.

[medievil]

How can CBT be better then going out with my friends all the time? Making new friends at my work, and other stuff.

Trust me i'm not the kind of guy that sits at home all day waiting for the magic pill that fixes everything up.

[aLurker]

How can CBT be better then going out with my friends all the time? Making new friends at my work, and other stuff.

Trust me i'm not the kind of guy that sits at home all day waiting for the magic pill that fixes everything up.

Good to hear. Although I was rather thinking along the lines of meditation to alleviate some of your ADHD-symptoms since you thought ADHD was implicated in your SA as well.

Btw you probably know this better than I do; is there anything to support that 80 mg/day of memantine is safe or what are some of the higher doses used in clinical trials? How is 80 mg treating you so far?

Edited by aLurker, 15 October 2010 - 08:04 PM.

[medievil]

80 mg was just to test wheter memantine is capabale of REVERSING tolerance, i'm still in the adaptation phase and i will know the results after the experiments, so far it makes me dizzy, and give me a double vision.

After i have my results i will return to 40mg a day wich works perfectly at slowing tolerance.

[medievil]

AMT works like a charm for my ADHD, i dont need an extra push for that, it also works like a charm for anhedonia and it lacks the amp buzz, so i actively go out to do stuff rather then enjoying my amp buzz and listen music all day.

I just need an extra push for my social anxiety, if something other then amphetamine can do it, then perfect.

[medievil]

Here a few situations where my SA is completely fixed:

- MDMA comedown, initially this produced an afterglow but after a few months i felt like shit afterwards (the opposite of a high lets say) yet my SA is 100% gone.

- On MDMA itself after massive abuse, it only induced dysphoria, paranoia, and other unpleasant side effects, yet my social anxiety was gone for 100%

- Comedown of amphetamine (recreational dose) feel absolutely horrible, depression, extreme paranoia, yet social anxiety is 100% fixed

- AMT reduces my anxiety significantly, also produces some euphoria (nowhere near the amp buzz) with selank the euphoria is abolished yet the anxiolytic effect is still there/

- On a recreational dose of MDMA and amphetamine, it can be suggested that its the euphoria that fixes my anxiety however above and under examples clearly indicate its not.

- GHB despite making me pretty euphoric reduces my SA with 0%

- Alcohol despite making me not care doesnt reduce my SA one bit.

- Opiates and benzo's same story.


What i want to hear are some possible explanations (animal is welcome too if it isnt a post about me abusing amp )

[medievil]

I was thinking about taking a recreational dose of amphetamine and then blocking the euphoria with naltrexone to see wheter i'm still free of SA.

My suspicion is that dopamine allevates my SA in a brainarea unrelated to hedonism and also a area where dopamine receptors dont downregulate as quick as in the other area's (eg crash is explained by reduction of half life + big time receptor downregulated, even tough there's still enough amp in the blood to be active.

[medievil]

I posted this a few times before too, anyway i will be sticking with AMT because it significantly helps with SA, OCD and ADD, it does give some euphoria but thats nothing like the amp like and buzz and definatly counterproductive.

Anyway guys, i beleive in serotonine releasers as the future antidepressants, 2 study's by nichols et al showed that they are superior to sertraline (1) and have a more rapid effect then standard antidepresants (2). SSRI's work by elevating serotonine however the serotonine autoreceptors lower serotonine again untill they downregulate and serotonine is elevated high enough for the patient to notice a antidepressant effect, however many patients are treatment resistant, activity of the 5HT1A autoreceptors has been associated with that atleast according to a study in mice (3).
Serotonine releasers effectively bypass the autoreceptors by forcing serotonine release resulting in a more robust response.

Some selective serotonine releasers are available as research chemicals however they dont have any research behind them in humans and could carry risk, an exception of this is AMT or alpha methyl tryptamine, it has been in clinical use for 20 years in the sovjet union, besides serotonine release its also a dopamine releaser wich further potentiates the antidepressant effects.

It is true that combined serotonine and dopamine release leads to neurotoxiticy, as seen with MDMA, however with MDMA there are 3 major factors contributing, first oxidative stress caused by massive monoamine release, AMT in low daily doses doesnt cause a massive elevation and oxidative stress will be minimal, hyperthermia if hyperthermia is abolished MDMA's neurotoxiticy is gone too, AMT in low doses doesnt cause any hyperthermia and last the toxic metabolites, wheter AMT has those is unclear (or i'm just not aware of that).

In conclusion i beleive that switching to a SSRI would decrease all benefits ive got up till now, and i beleive that the best strategy would be augmenting AMT.
AMT also lacks the impotence and other side effects seen with SSRI's, and it by itself fixes me up a great deal, so its definatly going to be a keeper.


1. The Effect of Selective Serotonin Releasing Agents in the Chronic Mild Stress Model of Depression in Rats.". Stress. PMID 9787258.
2. Effects of 5-HT-releasing agents on the extracellullar hippocampal 5-HT of rats. Implications for the development of novel antidepressants with a short onset of action. Unfortunately as a research chemical it's legality is subject to change. PMID 10428424.
3. RGS inhibition at Gαi2 selectively potentiates 5-HT1A–mediated antidepressant effects PNAS 107/24/11086

To replicate the results i get from AMT alone i would need quite a cocktail (and i even doubt it would be possible).

Edited by medievil, 16 October 2010 - 11:06 AM.

[Animal]

I don't believe AMT is a long term solution either, one of the reasons it was withdrawn from clinical use is because of toxicity issues, with many chronic users at the time suffering from symptoms indicating serotonergic neurotoxicity.

It's a common drug of abuse, you only have to browse Erowid to see how commonly it's abused in both small and high doses.

I also think you need to clarify your understanding on the significant clinical/subjective/chronic difference between a neurotransmitter releasing agent and a re-uptake inhibitor. Re-uptake inhibitors are far better therapeutic agents for extended periods of treatment, with much less abuse potential and sustained mechanisms of action. As opposed to the more rapid and transitory effects of releasing agents which generally come with a crash and minor-moderate toxicity issues.

I find it ironic that you seem to believe that drugs of abuse which provide instant gratification are the only substances which can have a therapeutic effect for you. This obviously stems from an addiction to their mood enhancing effects, euphoric or not. If you can't envisage a life without these physiologically/psychologically toxic substances then there really isn't much I can suggest to help you. The majority of pharmaceuticals that would be indicated in potentially treating your issues are contraindicated with potent neurotransmitter releasing agents. I mean you won't even consider some form of therapy, this really doesn't bode well for any kind of future recovery.

You'll inevitably burn out in the not too distant future, I hope you find the willpower to overcome your addictive personality before then.

[medievil]

I introduced AMT to a friend of me with social anxiety, i said it blew amp away for SA, however he said he didnt notice a thing, well he just didnt notice the buzz and wasnt looking for the therapeutic effect.

Point of this story is, your still thinking i only want substances wich provide me with a buzz, well thats not the case, but convincing you seems impossible.

I also think you need to clarify your understanding on the significant clinical/subjective/chronic difference between a neurotransmitter releasing agent and a re-uptake inhibitor. Re-uptake inhibitors are far better therapeutic agents for extended periods of treatment, with much less abuse potential and sustained mechanisms of action. As opposed to the more rapid and transitory effects of releasing agents which generally come with a crash and minor-moderate toxicity issues.

Your forgetting here how many ppl are treatment resistant to SSRI, wich has been associated with the autoreceptors (wich releasing agents bypass).

If i had to choise btw amp and AMT i would pick AMT hands down, it lacks the powerfull amp buzz (altough it causes some euphoria, but its only truly recreational in the psychedelic doses).


Sigh, just PM me your MSN adress, perhaps then you can understand what i want ( i wouldnt mind talking to you as your more pharmacology wise then me ) but you posting all the time how i want a buzz doesnt help anyone here.

Heck, i was even playing with the idea of low dose naltrexone to counteract the euphoria, and i was raving about selank despite it completely blocked AMT euphoria, so dunno convincing you on this board that i dont just want a buzz seems impossible, perhaps msn will do better, or am i a too diluded individual to chat with?

[Animal]

I introduced AMT to a friend of me with social anxiety, i said it blew amp away for SA, however he said he didnt notice a thing, well he just didnt notice the buzz and wasnt looking for the therapeutic effect.

Point of this story is, your still thinking i only want substances wich provide me with a buzz, well thats not the case, but convincing you seems impossible.

I also think you need to clarify your understanding on the significant clinical/subjective/chronic difference between a neurotransmitter releasing agent and a re-uptake inhibitor. Re-uptake inhibitors are far better therapeutic agents for extended periods of treatment, with much less abuse potential and sustained mechanisms of action. As opposed to the more rapid and transitory effects of releasing agents which generally come with a crash and minor-moderate toxicity issues.

Your forgetting here how many ppl are treatment resistant to SSRI, wich has been associated with the autoreceptors (wich releasing agents bypass).

If i had to choise btw amp and AMT i would pick AMT hands down, it lacks the powerfull amp buzz (altough it causes some euphoria, but its only truly recreational in the psychedelic doses).


Sigh, just PM me your MSN adress, perhaps then you can understand what i want ( i wouldnt mind talking to you as your more pharmacology wise then me ) but you posting all the time how i want a buzz doesnt help anyone here.

Heck, i was even playing with the idea of low dose naltrexone to counteract the euphoria, and i was raving about selank despite it completely blocked AMT euphoria, so dunno convincing you on this board that i dont just want a buzz seems impossible, perhaps msn will do better, or am i a too diluded individual to chat with?

Releasing agents do not bypass auto-receptors, they simply overwhelm them in the short term, tolerance will develop rapidly. Resistance to SSRI therapy, especially at the beginning of treatment is primarily associated with the broad 5-HT receptor stimulation; many 5-HT receptor subtypes have negative effects on mood and anxiety, it is their down-regulation that allows the therapeutic effects to become prominent. I wasn't specifically referring to SSRI's when I mentioned re-uptake inhibitors, don't assume that, there are a variety of pharmaceuticals with this mechanism of action.

I didn't mention you pursuing a buzz in my last post, I simply stated you seek instant gratification and potent mood enhancement, not necessarily euphoria. These kinds of effects are not conducive towards long term treatment and remission of your problems, and are contraindicated with many of the more sustained therapeutic agents. Rapid onset of enjoyable effects are highly associated with behavioural reinforcement, addiction, habituation, dependence and abuse.

Your refusal to consider life without AMT precludes most treatment options, and like I mentioned it isn't a long term solution to anything especially not considering it's toxicity issues.

Obviously you have an addiction this this kind of instant gratification, regardless of any 'buzz'. Your past history of (and current) drug abuse mean that you will have to forgo this kind of substance if you want to recover and resolve your issues. Since being dependent on such a substance will mean that the cycle of abuse will inevitably continue.

[medievil]

But animal, do you remember me raving about selank? I also mentioned that it completely blocked the amt euphoria, to the point that my mood was "ok" lower then my baseline good mood, but it was ok.

If i also want a mood boost why would i be happy with selank then?

In fact the first few days i was confused wheter i felt happy or down, the feeling of "ok" was new to me.

Releasing agents do not bypass auto-receptors, they simply overwhelm them in the short term, tolerance will develop rapidly. Resistance to SSRI therapy, especially at the beginning of treatment is primarily associated with the broad 5-HT receptor stimulation; many 5-HT receptor subtypes have negative effects on mood and anxiety, it is their down-regulation that allows the therapeutic effects to become prominent. I wasn't specifically referring to SSRI's when I mentioned re-uptake inhibitors, don't assume that, there are a variety of pharmaceuticals with this mechanism of action.

How do you explain then that AMT hasnt got any tolerance issues (atleast in the semi long term run).

especially not considering it's toxicity issues.

Source? Im fairly certain you got that from wikipedia, a good friend of me has put that there, he only assumed it was withdrawn because of toxicology issue, however a moderator on bluelight has checked the toxicology database of russia and didnt find anything regarding such toxic problems with AMT.

But anyway, do you want to help or not? All your posts toward me is about me being addicted and stuff related to that without a singly med solution.

Just drop your line of pharmaceuticals here you think can help in my case because at this point i'm pretty sure i wont get anything more out of you (if your even willing to do that, or is it gonna be another post how bad of an addict i am?)

[aLurker]

I might have misunderstood the situation here somewhat but here is my take on this so far:

The problem isn't you getting a buzz - that's fine.
The problems that Animal, IMHO correctly, points out rather seem to be long-term safety, instant gratification and that you won't even consider therapy.

Long-term safety:
AMT works great right now but has obvious risks that you probably know about yourself. Also it might stop you from finding a better long-term solution since it's contradicted by potential alternatives.

Instant gratification:
You seem to want instant results and you don't seem to have the patience to give things a proper change. Many prescription medications that might be useful in the long-run here require an extended adaption period to get results (and might also be contradicted by AMT and amp). What drugs without an instant onset have you given a proper chance (>1 month or so)? Memantine sure, yet that's partly to maintain or increase the instant gratification you get from the AMT and amp.

If a safe medication had a 15% chance of helping you but would require you not to combine it with any potent releasing agents (amp/AMT/MDMA and so on) and you wouldn't know the result for at least two months - would you try it for the full two months?

Edit: heh I wrote this post when you were only up to post 17, you guys write fast :p

Edited by aLurker, 17 October 2010 - 04:34 PM.

[medievil]

I might have misunderstood the situation here somewhat but here is my take on this so far:

The problem isn't you getting a buzz - that's fine.
The problems that Animal, IMHO correctly, points out rather seem to be long-term safety, instant gratification and that you won't even consider therapy.
I have been in contact with the person that saw all the safety data on AMT, and for me thats convincing, it has been in clinical use for 20 years. I dont care if i have to wait a while to see effects and as last i have the impression therapy is something to make the transision to real life exposure easysier and thus i think that when you have an active social life therapy cant do much, correct me when wrong.

Long-term safety:
AMT works great right now but has obvious risks that you probably know about yourself. Also it might stop you from finding a better long-term solution since it's contradicted by potential alternatives.
It wont stop me from anything at all, in fact one thing i find really important is being able to return to my baseline state without any withdrawals or anything else, this gives me also the opppertunity to try new things.

Instant gratification:
You seem to want instant results and you don't seem to have the patience to give things a proper change. Many prescription medications that might be useful in the long-run here require an extended adaption period to get results (and might also be contradicted by AMT and amp). What drugs without an instant onset have you given a proper chance (>1 month or so)? Memantine sure, yet that's partly to maintain or increase the instant gratification you get from the AMT and amp.

I was desperately trying to get MAOI's in the past, as i'm convinced of their effectiveness in SA but i couldnt get them, so your are completely wrong that i would never try a med that takes a long time to start working, heck i tried afobazole, wich takes at least 6 weeks to start working

If a safe medication had a 15% chance of helping you but would require you not to combine it with any potent releasing agents (amp/AMT/MDMA and so on) and you wouldn't know the result for at least two months - would you try it for the full two months?

No, 15% chance is pathetic, the 2 month thing isnt a problem tough.

Edit: heh I wrote this post when you were only up to post 17, you guys write fast :p

Answered in bold

[Animal]

Instant gratification:
You seem to want instant results and you don't seem to have the patience to give things a proper change. Many prescription medications that might be useful in the long-run here require an extended adaption period to get results (and might also be contradicted by AMT and amp). What drugs without an instant onset have you given a proper chance (>1 month or so)? Memantine sure, yet that's partly to maintain or increase the instant gratification you get from the AMT and amp.

If a safe medication had a 15% chance of helping you but would require you not to combine it with any potent releasing agents (amp/AMT/MDMA and so on) and you wouldn't know the result for at least two months - would you try it for the full two months?

This is the pertinent question...

[medievil]

Those questions have been answered in above post.

[medievil]

Anyone remember my lisuride thread? How i was raving about it? Kinda strange as that one would definatly have a long severe adaptation period before it works, maybe i was just confused and tought it would work right away .

I declined that med because of the costs tough, but i do have a shitload of ropinirole, willing to give it a try and willing to with the adaptation period, i took it for a couple of days but quit when i found out nmda antagonism also upregulates autoreceptors, so i wasnt able to adapt to it while on memantine.

Now that i think of this, its all a bit strange if i only want things that work instantly right?


Seems like i can get more suggestions out of the random idiot pdoc number 1 then this site

[aLurker]

My comments in bold italic.

I might have misunderstood the situation here somewhat but here is my take on this so far:

The problem isn't you getting a buzz - that's fine.
The problems that Animal, IMHO correctly, points out rather seem to be long-term safety, instant gratification and that you won't even consider therapy.
I have been in contact with the person that saw all the safety data on AMT, and for me thats convincing, it has been in clinical use for 20 years. I dont care if i have to wait a while to see effects and as last i have the impression therapy is something to make the transision to real life exposure easysier and thus i think that when you have an active social life therapy cant do much, correct me when wrong.

Therapy isn't just to make the transition easier. I'd say therapy is to change the underlying thought patterns that are connected to the problem. Medication is just a band-aid in comparison to actually realizing how you can solve your problems on your own. You seem to suffer from the limiting belief that only medication can help you reduce your anxiety. Sure medication help, but it isn't the only thing that might help you. Thoughts can change your neurochemistry too.

Long-term safety:
AMT works great right now but has obvious risks that you probably know about yourself. Also it might stop you from finding a better long-term solution since it's contradicted by potential alternatives.
It wont stop me from anything at all, in fact one thing i find really important is being able to return to my baseline state without any withdrawals or anything else, this gives me also the opppertunity to try new things.

Instant gratification:
You seem to want instant results and you don't seem to have the patience to give things a proper change. Many prescription medications that might be useful in the long-run here require an extended adaption period to get results (and might also be contradicted by AMT and amp). What drugs without an instant onset have you given a proper chance (>1 month or so)? Memantine sure, yet that's partly to maintain or increase the instant gratification you get from the AMT and amp.

I was desperately trying to get MAOI's in the past, as i'm convinced of their effectiveness in SA but i couldnt get them, so your are completely wrong that i would never try a med that takes a long time to start working, heck i tried afobazole, wich takes at least 6 weeks to start working
Why haven't you tried MAOIs yet if you are convinced of their effectiveness?

If a safe medication had a 15% chance of helping you but would require you not to combine it with any potent releasing agents (amp/AMT/MDMA and so on) and you wouldn't know the result for at least two months - would you try it for the full two months?

No, 15% chance is pathetic, the 2 month thing isnt a problem tough.
This worries me slightly since there might be several meds with those kinds of odds. If you would consider trying a few of them the odds of eventually finding a working solution would be quite high.

Edit: heh I wrote this post when you were only up to post 17, you guys write fast :p

Answered in bold

Now that i think of this, its all a bit strange if i only want things that work instantly right?

Glad you realize this.

Seems like i can get more suggestions out of the random idiot pdoc number 1 then this site

Perhaps.

[medievil]

Therapy isn't just to make the transition easier. I'd say therapy is to change the underlying thought patterns that are connected to the problem. Medication is just a band-aid in comparison to actually realizing how you can solve your problems on your own. You seem to suffer from the limiting belief that only medication can help you reduce your anxiety. Sure medication help, but it isn't the only thing that might help you. Thoughts can change your neurochemistry too.

Interesting, i'm thinking your referring to CBT? I'l take a look into that.

Why haven't you tried MAOIs yet if you are convinced of their effectiveness?

Because i now discovered AMT wich i beleive is more effecitve then a MAOI (or about the same) however without all the side effects (and i trust the russian documents on amts safety).

This worries me slightly since there might be several meds with those kinds of odds. If you would consider trying a few of them the odds of eventually finding a working solution would be quite high.

I would keep them for the last, as you could easily waste a few years when trying out such meds (kick in period, wash out period, repeat etc)


Were going round in circles here, i'm willing to wait 2 months to work no problem and also it doesnt have to provide an instant mood boost or cause some euphoria.

[medievil]

Well since the suggestions here arent coming, i personally was thinking off:

- Agomelatine
- Low dose naltrexone at night (to boost endorphine's during the day)
- Semax (seems to have potential for ADHD)
- High dose tandospirone wich seemed to produce excellent results in one clinical trial

Things i'm currently taking or stopped:

- Nevibilol a beta blocker wich increases testosterone i feel it helps because it blocks the nerveusness in certain situations, it also helps a TON with amp anxiety, but that could also be the cardesertan
- Cardesertan AT1 blockers showed promise for anxiety in rodents, so i'm also trialling that.
- Selank, temporary on hold as it changes the experience of other stuff, so wont to test those on their own first.

Stopped:

- Ritalin: personality chance
- Cymbalta: induced hypomania and killed my apetite so i didnt continue
- Amisulpiride: EXCELLENT for motivation and anhedonia, unfortionally it pooped out and never worked again.
- High dose buspar, on another forum we were playing with the idea that buspar was being underdosed leading to not enough postsynaptic activation, i aborted the experiment as the side effects where just horrible tough.
- St johns worth: zero effect
- Pentoxyfiline (bad spelling) didnt do anything
- Benzo's all of them, ativan, xanax, klonopin, valium and many more, they only give me double vision without anything else, not anxiolytic at all, a can of a energy drink is a far superior anxiolytic.

Probably forgot a few things, il keep updating this list.

Also remember guys my ADHD is very severe and the only thing that really seems to fix it is AMT, amphetamine does nothing for my ADHD, it actually demotivates me, modafinil was kinda neutral, didnt work, wellbutrin only tried once but gave me horrible anxiety. Ritalin seemed to change my personality and desoxypipradol doesnt work for my ADHD either, only 2 substances where able to motivate me and that were AMT and amisulpiride (with amt being far better) but i get permanently tolerant to ami.

Edited by medievil, 17 October 2010 - 07:06 PM.

[aLurker]

Well since the suggestions here arent coming, i personally was thinking off:

- Agomelatine
- Low dose naltrexone at night (to boost endorphine's during the day)
- Semax (seems to have potential for ADHD)
- High dose tandospirone wich seemed to produce excellent results in one clinical trial

Things i'm currently taking or stopped:

- Nevibilol a beta blocker wich increases testosterone i feel it helps because it blocks the nerveusness in certain situations, it also helps a TON with amp anxiety, but that could also be the cardesertan
- Cardesertan AT1 blockers showed promise for anxiety in rodents, so i'm also trialling that.
- Selank, temporary on hold as it changes the experience of other stuff, so wont to test those on their own first.

Stopped:

- Ritalin: personality chance
- Cymbalta: induced hypomania and killed my apetite so i didnt continue
- Amisulpiride: EXCELLENT for motivation and anhedonia, unfortionally it pooped out and never worked again.
- High dose buspar, on another forum we were playing with the idea that buspar was being underdosed leading to not enough postsynaptic activation, i aborted the experiment as the side effects where just horrible tough.
- St johns worth: zero effect
- Pentoxyfiline (bad spelling) didnt do anything
- Benzo's all of them, ativan, xanax, klonopin, valium and many more, they only give me double vision without anything else, not anxiolytic at all, a can of a energy drink is a far superior anxiolytic.

Probably forgot a few things, il keep updating this list.

Also remember guys my ADHD is very severe and the only thing that really seems to fix it is AMT, amphetamine does nothing for my ADHD, it actually demotivates me, modafinil was kinda neutral, didnt work, wellbutrin only tried once but gave me horrible anxiety. Ritalin seemed to change my personality and desoxypipradol doesnt work for my ADHD either, only 2 substances where able to motivate me and that were AMT and amisulpiride (with amt being far better) but i get permanently tolerant to ami.

I didn't know that Semax had such potential for ADHD, thanks for bringing that to my attention and let me know if you know of a good source. Agomelatine also seems interesting from a personal stand-point since it could help with both my ADD issues and delayed sleep phase.

Have you considered guanfacine for your ADHD? Just a thought since it might help with anxiety too.

Both Semax and guanfacine seem to suffer from two iffy problems though: they are both relatively new and very hard to get.

[medievil]

Yes ive been looking into guanfacine and will probably give it a try.

Only that damn horrible semax price sucks!

[aLurker]

Yes ive been looking into guanfacine and will probably give it a try.

Only that damn horrible semax price sucks!

What price? sauce??!??! The pharmacy1010 site is deader than disco!

[medievil]

Yes ive been looking into guanfacine and will probably give it a try.

Only that damn horrible semax price sucks!

What price? sauce??!??! The pharmacy1010 site is deader than disco!

I dont remember it in my head, but the 1% solution was pretty damn horribly expensive.