The Complete List Of Nootropics
LifeMirage 04 Dec 2002
Many Nootropics Americans first heard about (from IAS, LEF, Smart drug books, their doctors, or friends) are finally available in the US OTC (Piracetam, Pyritinol, Picamilon, Idebenone, Vincamine, Vinpocetine) while others; Hydergine, Deprenyl, Vasopressin, Centrophenoxine, Aniracetam, Oxiracetam are still available by prescription only in the US or in Europe. (God I hate the FDA).
But since the early and mid 1990's their have been no updates about new Nootropics either being researched or already approved in another country. until now. This part of the Nootropic forum will interactively provide info on new Nootropics you have never heard of. And will also discuss exactly how to define a Nootropic from a smart drugs with some nootropic effects, or a brain supplement.
LifeMirage 04 Dec 2002
(Nootropics with long-term effects with various actions throughout the brain.)
Piracetam
Pramiracetam
Oxiracetam
Nefiracetam
Aniracetam
DM235 (Sunifiram)
Nebracetam
Vinpocetine
Vincamine
Pyritinol
Idebenone
Hydergine
Smart Drugs with Nootropic effects
(Has Nootropic effects but a very specfic mode of action (1 or 2) and may be more short-term) [I consider these Mild Nootropics, not because of what you feel but because of how they work.]
Rasagiline
Deprenyl
Centrophenoxine
Huperzine A
Nicergoline
Galantamine
Picamilon
CDP-Choline
Alpha-Glycerol-Phoshoryl-Choline (GPC)
Vasopressin
Brain Supplements
(Not Nootropics but some people notice a difference, many people call them weak Nootropics)
ALC
Gingko
DMAE
Choline
PhosphatidylCholine
Carnosine
Bacopa
Note: All drugs that are currently being researched in the US can be found here: http://clinicaltrials.gov/ct/gui
Dutchman 24 Mar 2003
LifeMirage 27 Mar 2003
Cobalamin, Niacinamide, Folic Acid, 2-dimethylaminoethanol, Pyridoxine HCL, Pantothenic Acid (Calcium Pantothenate), Proprietary Cognamine™ Complex (including components of: Phosphatidylserine, Choline Bitartrate, Vinpocetine, Salix Alba, Thioctic Acid, L-Tyrosine, Ciwujia, and other synergistic compounds)
Basically; B-12, B-3, Folic Acid, DMAE, B-6, B-%, and an blend of PS, Choline, Vinpoceitne, Salix, Lipoic Acid, L-Tyrosine, Ciwujia, and other synergistic compounds.
Three Things that are bad about this product:
1 It's mostly vitamins.
2. The doses are unknown.
3. Contains unknown ingredients (other synergistic compounds)
It does have Vinpocetine which is a nootropic, but at an unknown dose.
I cannot recommend this product for those reasons. I do not believe it is comparable to any Nootropics or Nootropic formulas.
kevin 27 Mar 2003
At the website www.aor.ca that you posted some information from, for choline alfoscerate, I also found there a reference to an interesting product called benfotiamin which is a much more bioavailable form of thiamine. It appears to be an anti-glycating agent providing some neuroprotective capabilities. I was wondering what your feelings are on it as well as, in general, what your thoughts on the effectiveness of other anti-glycating/oxidizing agents on aging might be... although this would probably belong in a different thread.
Edited by kperrott, 27 March 2003 - 06:08 PM.
LifeMirage 29 Mar 2003
I'm glad you see you’re interested in this fascinating area of antiaging research. Benfotiamine (a derivative of the fat soluble form of Thiamine) has impressive anti-glycation effects. I am curious to see its effects compared to other Glycation inhibitors, such as, Carnosine, Pyridoxamine, and Aminoguanidine. Unfortunately no comparison studies have been conducted as far as I am aware of.
Based on animal & human studies Carnosine, Pyridoxamine, Benfotiamine are effective for slowing down glycation (while an important factor in aging not a direct cause). I plan to combine them all for maximum antiglycation effects.
ALT-711 is a glycation breaker, which can reverse glycation in the body safely. It is currently being studied for FDA approval and may be approved in a few years (although available now by various suppliers).
NtBHA is a very interesting spinning trap agent which (although needs more studies) may increase lifespan.
SOD or analogs of may increase lifespan (but again needs more studies).
R-Lipoic Acid also looks promising.
Deprenyl I believe everyone knows my opinion.
Edited by LifeMirage, 29 March 2003 - 02:28 AM.
LifeMirage 08 Oct 2003
Ceruletide improves event-related potential indicators of cognitive processing in young but not in elderly humans.
Dodt C, Sarnighausen HE, Pietrowsky R, Fehm HL, Born J. Department of Internal Medicine, Medical University of Lubeck, Germany.
The effect of intravenously administered ceruletide, a cholecystokinin (CCK) analogue, on neurophysiologic signs of stimulus processing was tested in 16 young (19-28 years) and 16 aged (70-86 years) healthy subjects. Placebo or 2.5 micrograms ceruletide was infused within 30 minutes according to a double-blind within-subject crossover design. Thereafter, auditory event-related brain potential (AERP) responses to stimuli of an "oddball" task (including the random presentation of frequent standard tones and rare target tones) were recorded. Amplitudes of the P2, P3, and SW components of the AERP were reduced in aged subjects (p < 0.05, p < 0.001, and p < 0.01, respectively), and latencies (from stimulus onset) of the N2 and P3 components were prolonged (p < 0.05 and p < 0.01, respectively). Together, these changes indicate impaired cognitive processing capabilities in aged compared with young subjects. Ceruletide enhanced P3 and also the subsequent slow-wave (SW) component that occurs 500 to 700 ms poststimulus in young subjects (p < 0.05 and p < 0.001, respectively). The peptide did not at all affect AERPs in the elderly subjects. Results demonstrate the capability of ceruletide after systemic administration to enhance central nervous system indicators of cognitive processing such as P3 and SW in young subjects. However, despite the clear effect of the CCK analogue in young subjects, it remained ineffective in the group of aged subjects and, thus, failed to compensate for the decline in AERP signs of working memory functioning in the elderly subjects.
Glycine In Healthy Young Adults
J Clin Psychopharmacol 1999 Dec;19(6):506-12
Beneficial effects of glycine (bioglycin) on memory and attention in young and middle-aged adults.
File SE, Fluck E, Fernandes C. Psychopharmacology Research Unit, United Medical and Dental Schools of Guy's and St Thomas' Hospitals, Guy's Hospital, London, United Kingdom.
The N-methyl D-aspartate receptor complex is involved in the mechanism of long-term potentiation, which is thought to be the biological basis of learning and memory. This complex can be manipulated in a number of ways, one of which is through the strychnine-insensitive glycine receptor coagonist site. The effects of Bioglycin (Konapharma, Pratteln, Switzerland), a biologically active form of the amino acid glycine, were therefore studied in healthy students (mean age, 20.7 years) and middle-aged men (mean age, 58.9 years) with tests that measured attention, memory and mood, using a double-blind, randomized, crossover design. Compared with the young group, the middle-aged group had significantly poorer verbal episodic memory, focused, divided, and sustained attention; they also differed in their subjective responses at the end of testing. Bioglycin significantly improved retrieval from episodic memory in both the young and the middle-aged groups, but it did not affect focused or divided attention. However, the middle-aged men significantly benefited from Bioglycin in the sustained-attention task. The effects of Bioglycin differed from those of other cognitive enhancers in that it was without stimulant properties or significant effects on mood, and it primarily improved memory rather than attention. It is likely to be of benefit in young or older people in situations where high retrieval of information is needed or when performance is impaired by jet lag, shift work, or disrupted sleep. It may also benefit the impaired retrieval shown in patients with schizophrenia, Parkinson's disease, and Huntington's disease.
Vyssh Nerv Deiat Im I P Pavlova 1997 Mar-Apr;47(2):420-30
A nootropic adrenocorticotropin analog 4-10-semax (l5 years experience in its design and study)
Asmarin IP, Nezavibat'ko VN, Miasoedov NF, Kamenskii AA, Grivennikov IA, Ponomareva-Stepnaia MA, Andreeva LA, Kaplan AIa, Koshelev VB, Riasina TV.
Semax is one of the rare analogues of regulatory peptides which underwent all stages from fundamental investigations to practical usage. It has been demonstrated that this peptide is capable to stimulate operative memory and attention, to increase resistance to hypoxia and to improve brain circulation in experimental animals and human beings over prolonged period (20-24 h after intranasal administration in doses 0.015-0.050 mg/kg). Semax significantly improves memory and attention in healthy men under extreme conditions of activities. Moreover at present semax is successfully used in treatment of patients with different diseases of CNS. In the majority of cases the peptide exhibited positive effects and in no case it produced negative side actions or complications connected with its administration. There is good reason to believe that medical potentialities of semax have not been exhausted and in future new possibilities of its usage will be revealed.
Therapie 2002 Mar-Apr;57(2):137-50
New drugs derived from medicinal plants.
Zhang JT. Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, P.R. China.
In China, increasing emphasis has been laid in recent years on research on natural products. About 140 new drugs have been developed from Chinese medicinal plants. For example, anisodamine possesses good effects in the treatment of septic shock and morphine addiction; 3-n-butylphthalide isolated from seeds of celery was shown to be a new cerebral anti-ischemic agent; indirubin was identified as an anti-leukemic drug with no inhibition of bone marrow; huperzine is a potent and reversible inhibitor of acetylcholinesterase (AChE) and its selective action is superior to that of donepezil; clausenamide was shown to be a potassium channel blocker, its nootropic effect was 50-100 times more potent than that of piracetam; bicyclol was synthesized from schizandrin C isolated from Fructus schizandrae. It has remarkable hepatoprotective and certain anti-hepatitis virus actions; salvianolic acid B is a very strong antioxidant agent with potential anti-dementia effects; yingzhaosu A and artemisinin are anti-malaria drugs containing a peroxide ring which is very rarely seen in natural substances.
Medline studies
Edited by LifeMirage, 05 April 2005 - 06:28 PM.
0824 08 Oct 2003
I have a question for the discussion group. What is the best nootropic for the treatment of anxiety disorder / tourettes syndrome? [?]
I am taking choline/vitamin C powder. Right now it is not really working to well. Any info will be welcomed. Thanks, HigherMinds
LifeMirage 08 Oct 2003
Deprenyl... Promising results could be observed in one study of Tourette's syndrome using an average dosis of 8.1 mg/ day.
0824 12 Oct 2003
It is me again, with a question on tourettes and how nootropics can help. Is s DL-Phenylalanine a dopamine agonists. My reason for asking is that dopamine agonists seem to increase the tics both vocal and non vocal in tourette syndorme paients. I thought about taking it but if this is the case I may need to leave it on the shelf. Also thanks for the info on Theanine, I will give it a try. What is the best brand to take: and also do they have it in the powdered form or just pill form. I will most likely take 200 mg since that seems what most people find the most benifts. I will keep the board updated. Thanks again, HigherMind 0824
noos 13 Oct 2003
Greetsing for HigherMinds.
It is me again, with a question on tourettes and how nootropics can help. Is s DL-Phenylalanine a dopamine agonists. My reason for asking is that dopamine agonists seem to increase the tics both vocal and non vocal in tourette syndorme paients. I thought about taking it but if this is the case I may need to leave it on the shelf. Also thanks for the info on Theanine, I will give it a try. What is the best brand to take: and also do they have it in the powdered form or just pill form. I will most likely take 200 mg since that seems what most people find the most benifts. I will keep the board updated. Thanks again, HigherMind 0824
theanine? isn´t that it increases dopamine too? just what you don´t want...
LifeMirage 14 Oct 2003
L-Phenylalanine is a precursor to Dopamine, the D- form is a precursor to PEA (Phenylethylamine), which can effect Dopamine release.
What is the best brand to take: and also do they have it in the powdered form or just pill form. I will most likely take 200 mg since that seems what most people find the most benefits. I will keep the board updated.
Theanine is sold in tablets (source naturals) and powder form (beyond a century).
I have used up to 1,000 mg with no side effects. I would recommend start off around 400-600 mg for a therapeutic indication.
theanine? isn´t that it increases dopamine too? just what you don´t want...
Theanine (Gamma EthylAmine Glutamic acid) is a unique precursor for GABA (probably the strongest next to GHB). It does appear to have the ability to release Dopamine as well, but not to a strong degree.
0824 21 Oct 2003
Thanks HigherMinds of the Triangle
bradcure 14 Dec 2003
staz 16 Dec 2003
Edited by staz, 27 December 2003 - 10:43 AM.
zoolander 20 May 2006
Elusive 20 May 2006
Brainbox 20 May 2006
Lets see if LifeMirages recommendations were scientifically backed or whether they were driven by the marketing dollar
If these kind of issues were that kind of simple.... )
Peak Noots 17 Feb 2013
Thanks,
PeakNootropics.com
chung_pao 17 Feb 2013
Here you go: http://en.wikipedia.org/wiki/Nootropic
Nearly a complete list.
Stock up on products of mainly two categories: the New and exciting, and the Old and reliably effective.
Ex. I love my piracetam and have great belief in its usefulness.
However, I'd like to try what's new to keep this hobby interesting. I'm referring to what's talked about on the boards: phenylpiracetam, armodafinil (for example).
Sell what's getting most attention in the media, and what the experienced recommends.
Also, try to keep information about each product SHORT and RELIABLE.
Summarize the benefits of each product briefly and back it up with references.
Just giving you my opinion as a consumer. Honestly, most of us don't care which brand is on the product. Nearly everyone has the same Chinese suppliers anyway.
As long as we get the products without hassle, for a good price and no funny business (diluted or wrong product).
If you could sell Phenylpiracetam, Piracetam, the usual cholines, Noopept and the eugeroics, for a better price than Cerebralhealth and Smartpowders, I'd choose you before the other suppliers any day.