3 replies to this topic

[freyley]

Hi,

I've been waking up tired and with a headache (after anywhere from 8-11 hours of sleep) for years now, and seeing the discussion of piracetam and brainfog/headaches reduced by choline, I was curious whether that might help me too. I get something I'd call brain fog in the mid afternoon after working/thinking a lot, and I've noticed that eggs help it. I also have restless legs syndrome, which isn't unpleasant or particularly worth treating (especially when compared to the treatments), but seems to be neurological, so relevant. I do take magnesium and sometimes calcium and it helps a little.

Some years ago I took DLPA and Tyrosine capsules on different days (several day separation). DLPA made me alert, happier, energetic...and also hyper, and super twitchy. L-tyrosine made me super twitchy and gave me cramps, but may also have reduced my fatigue.

Yesterday I took my first choline supplement, a 250mg choline bitartrate, 250mg inositol combo pill. I started getting cramps but took a couple of calcium/magnesium pills and that seemed to help. Today I jumped out of bed with lots of energy and no headache after 6 hours of sleep, but oh my god I've been hyper and manic all day.

Anyone have any suggestions or thoughts? I've got DMAE and acetyl-l-carnitine to try as alternatives to the choline pill. I would really appreciate the energy, but the twitchy is not fun at all.

Edited by freyley, 03 November 2010 - 10:05 PM.

[NR2(x)]

The fatigue and RLS/twitchness sounds like mainly a "dopamine" problem. Therefore you may only stragiht tradeoff between the two. Have you found coping stratergies to deminish RLS?
Add the ALCAR to the choline. Idebenone could be interesting. I dont have any real specific ideas. Seleniomethionine from yeast has dramatically increased my exercise energy and causes a wooping reduction in cancer mortaility, pubmed it.

[jadamgo]

The fatigue and RLS/twitchness sounds like mainly a "dopamine" problem. Therefore you may only stragiht tradeoff between the two. Have you found coping stratergies to deminish RLS?
Add the ALCAR to the choline. Idebenone could be interesting. I dont have any real specific ideas. Seleniomethionine from yeast has dramatically increased my exercise energy and causes a wooping reduction in cancer mortaility, pubmed it.

Adding picamilon, or a cup of strong chamomile tea every few hours (2-3 teabags per cup), should help significantly with the excessive activation. Chamomile is overlooked by many, but in high doses it's a very effective anxiolytic. That's why it's the main ingredient in Celestial Seasoning's famous sleepytime tea. Though you would need about 2-4 teabags for significant help in falling asleep. (Unless the placebo effect from one teabag is good enough to do the job.)

IIRC, RLS is usually associated with lack of dopamine, not excessive dopamine. That's why it's sometimes treated with amantadine, or selegiline. So you could reasonably expect improvement in RLS by taking tyrosine, or perhaps DLPA. Iron is also helpful.

I second the recommendation to add ALCAR.

[freyley]

Adding picamilon, or a cup of strong chamomile tea every few hours (2-3 teabags per cup), should help significantly with the excessive activation. Chamomile is overlooked by many, but in high doses it's a very effective anxiolytic. That's why it's the main ingredient in Celestial Seasoning's famous sleepytime tea. Though you would need about 2-4 teabags for significant help in falling asleep. (Unless the placebo effect from one teabag is good enough to do the job.)

IIRC, RLS is usually associated with lack of dopamine, not excessive dopamine. That's why it's sometimes treated with amantadine, or selegiline. So you could reasonably expect improvement in RLS by taking tyrosine, or perhaps DLPA. Iron is also helpful.

I second the recommendation to add ALCAR.

I'm beginning to suspect that along with not having a single source, RLS doesn't have a single metabolic cause. Also please do not ever recommend taking iron without a ferritin level again. It can be extremely dangerous. I am replying solely so that people don't come across this post and decide to take iron supplements because they have RLS.