25 replies to this topic

[Shulginstestsubject]

People seem to report that resveratrol has a stimulating effect. Is this true? I'm thinking about starting a resveratrol regimen. I want to know if you can feel it sort of "kick in" and if it will keep you awake and alert. Since it is said that resveratrol mimics the physiological effects of calorie restriction, I am wondering if it exhibits these effects by means of orexin/hypocretin release. This is the same mechanism as Modafinil. Could one use resveratrol as an alternative to modafinil? If resveratrol does have a stimulant effect, to what extent does it exhibit these effects? Is there appetite suppression (indicating a positive effect on dopamine), increased locomotor activity, better focus, reversal of depression, talkativeness, insomnia, subjective grandiosity etc. Could you use it as a study aid? Are the effects moreso physiological than psychoactive? Do you feel more motivated? Thank you

[amark]

I feel stronger. It is not like caffeine or modafinal at all. It hits after about 30 minutes. It has zero affects on wakefulness or attention.

People seem to report that resveratrol has a stimulating effect. Is this true? I'm thinking about starting a resveratrol regimen. I want to know if you can feel it sort of "kick in" and if it will keep you awake and alert. Since it is said that resveratrol mimics the physiological effects of calorie restriction, I am wondering if it exhibits these effects by means of orexin/hypocretin release. This is the same mechanism as Modafinil. Could one use resveratrol as an alternative to modafinil? If resveratrol does have a stimulant effect, to what extent does it exhibit these effects? Is there appetite suppression (indicating a positive effect on dopamine), increased locomotor activity, better focus, reversal of depression, talkativeness, insomnia, subjective grandiosity etc. Could you use it as a study aid? Are the effects moreso physiological than psychoactive? Do you feel more motivated? Thank you

[maxwatt]

Most people notice no effect with a pure extract; users of 50% extracts or mixtures with grape seed have reported a speedy "buzz". Resveratrol affects the CLK genes, and can upset circadian rhythms if taken at night; this can be counteracted by the use of low-dose melatonin. Some people feel the get greater focus and clarity, but this could likely be a placebo effect. It does seem to at to reduce inflammation via nfKappa-B inibition, rather than as an NSAID does via COX inhibition. Some people report a sense of well-being during the first few weeks of taking the supplement, but again, this could be placebo. Another effect reported is an indifference tocold -- you know it's cold, but it doesn't bother you.

In short, resveratrol acts nothing like a nootropic drug. You will probably notice no major differences in mood or performance. Long term, some people have reported improved aerobic performance in sports. This may have some basis in mitochondrial biogenesis, as reported in mice that were fed high doses.

[Shulginstestsubject]

okay, thank you guys for clearing this up for me. I thought that since it can regulate circadian rhythms, then it would have a wakefulness-promoting effect at first, then it would help you sleep at night.

[2tender]

People seem to report that resveratrol has a stimulating effect. Is this true? I'm thinking about starting a resveratrol regimen. I want to know if you can feel it sort of "kick in" and if it will keep you awake and alert. Since it is said that resveratrol mimics the physiological effects of calorie restriction, I am wondering if it exhibits these effects by means of orexin/hypocretin release. This is the same mechanism as Modafinil. Could one use resveratrol as an alternative to modafinil? If resveratrol does have a stimulant effect, to what extent does it exhibit these effects? Is there appetite suppression (indicating a positive effect on dopamine), increased locomotor activity, better focus, reversal of depression, talkativeness, insomnia, subjective grandiosity etc. Could you use it as a study aid? Are the effects moreso physiological than psychoactive? Do you feel more motivated? Thank you

There is a collective placebo effect of this nature. I wouldnt depend on it as a stimulant, it does potentiate stamina though. Taking it afternoons can make sleep difficult. It demonstrates no psychotropic effects, perhaps some mood elevation, nothing overt, but there is consistency. I find it works better if cycled with regular off periods. Its nothing like trimethoxyphenethylamine.

[Shulginstestsubject]

People seem to report that resveratrol has a stimulating effect. Is this true? I'm thinking about starting a resveratrol regimen. I want to know if you can feel it sort of "kick in" and if it will keep you awake and alert. Since it is said that resveratrol mimics the physiological effects of calorie restriction, I am wondering if it exhibits these effects by means of orexin/hypocretin release. This is the same mechanism as Modafinil. Could one use resveratrol as an alternative to modafinil? If resveratrol does have a stimulant effect, to what extent does it exhibit these effects? Is there appetite suppression (indicating a positive effect on dopamine), increased locomotor activity, better focus, reversal of depression, talkativeness, insomnia, subjective grandiosity etc. Could you use it as a study aid? Are the effects moreso physiological than psychoactive? Do you feel more motivated? Thank you

There is a collective placebo effect of this nature. I wouldnt depend on it as a stimulant, it does potentiate stamina though. Taking it afternoons can make sleep difficult. It demonstrates no psychotropic effects, perhaps some mood elevation, nothing overt, but there is consistency. I find it works better if cycled with regular off periods. Its nothing like trimethoxyphenethylamine.

Thanks for clearing that up for me, it sounds pretty accurate from what I can see just from the posts. And isn't trimethoxyphenethylamine just mescaline haha. I guess you're right, resveratrol isn't anything like mescaline. I respect that your intention may have been to compare it to mescaline, but maybe you were mistaking it for AlphaMethylPHenEThylAMINE (amphetamine).

[bixbyte]

In short, resveratrol acts nothing like a nootropic drug. You will probably notice no major differences in mood or performance. Long term, some people have reported improved aerobic performance in sports. This may have some basis in mitochondrial biogenesis, as reported in mice that were fed high doses.

YES my wife does 4 miles a day.
When I lose the res "feel" I add an Ferrous Gluconate - Iron 27 mg tablet.
Have you ever tried adding an iron pick up?

[maxwatt]

In short, resveratrol acts nothing like a nootropic drug. You will probably notice no major differences in mood or performance. Long term, some people have reported improved aerobic performance in sports. This may have some basis in mitochondrial biogenesis, as reported in mice that were fed high doses.

YES my wife does 4 miles a day.
When I lose the res "feel" I add an Ferrous Gluconate - Iron 27 mg tablet.
Have you ever tried adding an iron pick up?

Not without knowing that my iron levels are low. It is not something I would do casually.

[Thorsten3]

People seem to report that resveratrol has a stimulating effect. Is this true? I'm thinking about starting a resveratrol regimen. I want to know if you can feel it sort of "kick in" and if it will keep you awake and alert. Since it is said that resveratrol mimics the physiological effects of calorie restriction, I am wondering if it exhibits these effects by means of orexin/hypocretin release. This is the same mechanism as Modafinil. Could one use resveratrol as an alternative to modafinil? If resveratrol does have a stimulant effect, to what extent does it exhibit these effects? Is there appetite suppression (indicating a positive effect on dopamine), increased locomotor activity, better focus, reversal of depression, talkativeness, insomnia, subjective grandiosity etc. Could you use it as a study aid? Are the effects moreso physiological than psychoactive? Do you feel more motivated? Thank you

It has a weird effect on me. It feels like increased estrogeon, I become more 'nice'. It wasn't something I was overly keen on because I tend to suffer with 'niceity syndrome' as it is. It wasn't something that made me feel any more assertive.
I have stopped taking it as I don't think I need it. I don't eat too many calories per day and there isn't a grain of fat on me so wouldn't need its help in this area. Maybe there are other benefits of it that would justify me to keep taking it? They would have to be pretty concrete for me to make the effort considering the price of it.
I was also interested in curcumin but it gave me horrific heartburn and a weird heavy mental effect (like i'd been punched in the head or something). May experiment again with it but it's not something I'm going to rush back into, it's probably not even neccessary for me.

Edited by Thorsten, 12 November 2010 - 04:51 PM.

[aLurker]

People seem to report that resveratrol has a stimulating effect. Is this true? I'm thinking about starting a resveratrol regimen. I want to know if you can feel it sort of "kick in" and if it will keep you awake and alert. Since it is said that resveratrol mimics the physiological effects of calorie restriction, I am wondering if it exhibits these effects by means of orexin/hypocretin release. This is the same mechanism as Modafinil. Could one use resveratrol as an alternative to modafinil? If resveratrol does have a stimulant effect, to what extent does it exhibit these effects? Is there appetite suppression (indicating a positive effect on dopamine), increased locomotor activity, better focus, reversal of depression, talkativeness, insomnia, subjective grandiosity etc. Could you use it as a study aid? Are the effects moreso physiological than psychoactive? Do you feel more motivated? Thank you

It has a weird effect on me. It feels like increased estrogeon, I become more 'nice'. It wasn't something I was overly keen on because I tend to suffer with 'niceity syndrome' as it is. It wasn't something that made me feel any more assertive.
I have stopped taking it as I don't think I need it. I don't eat too many calories per day and there isn't a grain of fat on me so wouldn't need its help in this area. Maybe there are other benefits of it that would justify me to keep taking it? They would have to be pretty concrete for me to make the effort considering the price of it.
I was also interested in curcumin but it gave me horrific heartburn and a weird heavy mental effect (like i'd been punched in the head or something). May experiment again with it but it's not something I'm going to rush back into, it's probably not even neccessary for me.

I hear deprenyl cures 'niceity syndrome', just ask Animal

[Thorsten3]

People seem to report that resveratrol has a stimulating effect. Is this true? I'm thinking about starting a resveratrol regimen. I want to know if you can feel it sort of "kick in" and if it will keep you awake and alert. Since it is said that resveratrol mimics the physiological effects of calorie restriction, I am wondering if it exhibits these effects by means of orexin/hypocretin release. This is the same mechanism as Modafinil. Could one use resveratrol as an alternative to modafinil? If resveratrol does have a stimulant effect, to what extent does it exhibit these effects? Is there appetite suppression (indicating a positive effect on dopamine), increased locomotor activity, better focus, reversal of depression, talkativeness, insomnia, subjective grandiosity etc. Could you use it as a study aid? Are the effects moreso physiological than psychoactive? Do you feel more motivated? Thank you

It has a weird effect on me. It feels like increased estrogeon, I become more 'nice'. It wasn't something I was overly keen on because I tend to suffer with 'niceity syndrome' as it is. It wasn't something that made me feel any more assertive.
I have stopped taking it as I don't think I need it. I don't eat too many calories per day and there isn't a grain of fat on me so wouldn't need its help in this area. Maybe there are other benefits of it that would justify me to keep taking it? They would have to be pretty concrete for me to make the effort considering the price of it.
I was also interested in curcumin but it gave me horrific heartburn and a weird heavy mental effect (like i'd been punched in the head or something). May experiment again with it but it's not something I'm going to rush back into, it's probably not even neccessary for me.

I hear deprenyl cures 'niceity syndrome', just ask Animal

LMAO

[bixbyte]

In short, resveratrol acts nothing like a nootropic drug. You will probably notice no major differences in mood or performance. Long term, some people have reported improved aerobic performance in sports. This may have some basis in mitochondrial biogenesis, as reported in mice that were fed high doses.

YES my wife does 4 miles a day.
When I lose the res "feel" I add an Ferrous Gluconate - Iron 27 mg tablet.
Have you ever tried adding an iron pick up?

Not without knowing that my iron levels are low. It is not something I would do casually.

___________

21 Century - Dietary Supplement
Iron 27 milligram
Ferrous Gluconate
110 tablets
Facts:
Calcium 110 mg 11% Daily Value
Iron 27 mg 100% Daily Value
Directions: Take one (1) tablet daily with any meal for maximum daily results,
or as directed by a medical practitioner.
_______

MAX, I am not allowed to take an IRON pill with RES?

[maxwatt]

In short, resveratrol acts nothing like a nootropic drug. You will probably notice no major differences in mood or performance. Long term, some people have reported improved aerobic performance in sports. This may have some basis in mitochondrial biogenesis, as reported in mice that were fed high doses.

YES my wife does 4 miles a day.
When I lose the res "feel" I add an Ferrous Gluconate - Iron 27 mg tablet.
Have you ever tried adding an iron pick up?

Not without knowing that my iron levels are low. It is not something I would do casually.

___________

21 Century - Dietary Supplement
Iron 27 milligram
Ferrous Gluconate
110 tablets
Facts:
Calcium 110 mg 11% Daily Value
Iron 27 mg 100% Daily Value
Directions: Take one (1) tablet daily with any meal for maximum daily results,
or as directed by a medical practitioner.
_______

MAX, I am not allowed to take an IRON pill with RES?

Most men do not need supplementary iron, nor women past menarche. Excess iron can be damaging. Optimum iron levels are on the low side of what is considered normal.

[david ellis]

21 Century - Dietary Supplement
Iron 27 milligram
Ferrous Gluconate
110 tablets
Facts:
Calcium 110 mg 11% Daily Value
Iron 27 mg 100% Daily Value
Directions: Take one (1) tablet daily with any meal for maximum daily results,
or as directed by a medical practitioner.
_______

MAX, I am not allowed to take an IRON pill with RES?

Most men do not need supplementary iron, nor women past menarche. Excess iron can be damaging. Optimum iron levels are on the low side of what is considered normal.

A big problem with iron is its ability to oxidize and cause damage. The iron that is not being used is stored in ferritin. Excess (say over 100
ng/mL) is dangerous because of the oxidative damage when a cardiac event or accident happens and the ferritin releases its iron. Reference levels of ferritin are 22-322 ng/mL(LabCorp). 50-100 ng/mL are sufficient reserves in case you have an emergency or two and need more iron. Most men have high levels of ferritin because of our evolutionary history. Iron was scarce and frequently needed to replace blood loss from parasites and wounds. I donate blood to keep my ferritin low.

[longevitynow]

Various doses of various resveratrols, haven't noticed a thing. On the other hand my blood sugar levels are great and I have very little body fat. Generally limit my sugar consumption except for low amounts as a treat. If someone had sugar/insulin issues I'd recommend it in a minute.

[maxwatt]

Various doses of various resveratrols, haven't noticed a thing. On the other hand my blood sugar levels are great and I have very little body fat. Generally limit my sugar consumption except for low amounts as a treat. If someone had sugar/insulin issues I'd recommend it in a minute.

Why? There are no human trials where resveratrol alone has reduced blood sugar.
The results in combination with metformin weren't impressive, either.

[longevitynow]

Various doses of various resveratrols, haven't noticed a thing. On the other hand my blood sugar levels are great and I have very little body fat. Generally limit my sugar consumption except for low amounts as a treat. If someone had sugar/insulin issues I'd recommend it in a minute.

Why? There are no human trials where resveratrol alone has reduced blood sugar.
The results in combination with metformin weren't impressive, either.

I will stand semi-corrected. I have read online in numerous places that Resveratrol was good for balancing blood sugar and/or diabetes. But I punched it into wikipedia for a quick if incomplete peek, and they said there was one study but it looks like it was basically a study done for a company to promote their Resveratrol product. I imagine some other companies decided to pick up on this and started claiming the same. A good reminder for all of us to check the real research on products as opposed to all of the internet hype! I take a resveratrol/grape seed extract combo and even recommended it to my aunt with very high blood sugar. I think it is still good for her but the ALA and chromium I also suggested are better validated at this time.

[MacGregor]

Various doses of various resveratrols, haven't noticed a thing. On the other hand my blood sugar levels are great and I have very little body fat. Generally limit my sugar consumption except for low amounts as a treat. If someone had sugar/insulin issues I'd recommend it in a minute.

Why? There are no human trials where resveratrol alone has reduced blood sugar.
The results in combination with metformin weren't impressive, either.

In human clinical trials, resveratrol has lowered blood sugar levels in both Phase Ib and Phase IIa, conducted by Sirtris Pharmaceuticals, Inc.

Am I missing something?

[MacGregor]

Various doses of various resveratrols, haven't noticed a thing. On the other hand my blood sugar levels are great and I have very little body fat. Generally limit my sugar consumption except for low amounts as a treat. If someone had sugar/insulin issues I'd recommend it in a minute.

Why? There are no human trials where resveratrol alone has reduced blood sugar.
The results in combination with metformin weren't impressive, either.

I will stand semi-corrected. I have read online in numerous places that Resveratrol was good for balancing blood sugar and/or diabetes. But I punched it into wikipedia for a quick if incomplete peek, and they said there was one study but it looks like it was basically a study done for a company to promote their Resveratrol product. I imagine some other companies decided to pick up on this and started claiming the same. A good reminder for all of us to check the real research on products as opposed to all of the internet hype! I take a resveratrol/grape seed extract combo and even recommended it to my aunt with very high blood sugar. I think it is still good for her but the ALA and chromium I also suggested are better validated at this time.

Would that company be the one I mentioned earlier, Sirtis?

Just because they make the product doesn't mean the study is complete B.S.

And its not like they are the first pharma co to rig studies, if thats truly the case.

[maxwatt]

Various doses of various resveratrols, haven't noticed a thing. On the other hand my blood sugar levels are great and I have very little body fat. Generally limit my sugar consumption except for low amounts as a treat. If someone had sugar/insulin issues I'd recommend it in a minute.

Why? There are no human trials where resveratrol alone has reduced blood sugar.
The results in combination with metformin weren't impressive, either.

In human clinical trials, resveratrol has lowered blood sugar levels in both Phase Ib and Phase IIa, conducted by Sirtris Pharmaceuticals, Inc.

Am I missing something?

My recollection is they used resveratrol in conjunction with metformin. Metformin does lower blood sugar, I don't recall if there was an additive effect, but I have the impression it was magina at best. I should review the studies. I've yet to see a study where resveratrol alone has lowered human serum glucose. I would love to.

Edited by maxwatt, 29 November 2010 - 11:49 AM.

[MacGregor]

It is nice to know everything a supplement is capable of doing, but it cracks me up that every supplement (lately) has to be the savior of mankind.

[tommix]

I can bet NON of you will look younger, or get significant difference in BIOage test then those who's not taking it. I think all those supplements don't work, i think need to get better purity and higher doses.
And better of all - STOP EATING SO MUCH! 5times more then chinese! 3x more then europe.. Shame. Most people in easter europe eats 2300 kcal per day, americans get this in one meal :D

Edited by tommix, 01 December 2010 - 03:22 PM.

[2tender]

Agreed, regarding supplement hoopla and hype, calorie intake, etc. But, its obvious that some people dont get beneficial results from Resveratrol. I think it may have something to do with age, and in some cases, the presence of a health related ailment. Then again, perhaps placebo.

[SpawnMoreOverlords]

I definately get non-placebo effect from resveratrol. I start my morning with brushing my teeth then lodging about half a gram of M98 micronized between my gums and cheeks. Half an hour later I take a large soft toothbrush and brush my entire mouth with remaining resveratrol for several minutes. Unlike many other supplements, where I will feel definite change in perception after taking it only for the first time or after a very long break(piracetam, citicholine, others), which is likely placebo, this one works solid for 2 weeks straight now, and effect is identical in nature every day. Kinda of a gentle rushing feeling to the head, wakefulness, slight stimulation and best of all complete removal of tiredness/sluggishness ; its much more pronounced when I have an over-exerting day prior, and even after 8 hours of sleep I wake completely drained. The effect is just as clear as drinking the cup of black tea, there can be no mistake that it's a placebo. Biggest measurable factor Is that my endurance goes up x1.5-2 everytime as opposed when I don't - it shows on the distance I can jog in the morning before I resort to walking to catch my breath. It seems like I'm one of the minorities here that experience such an effect, I would to figure out why.

Edited by SpawnMoreOverlords, 28 February 2013 - 03:33 PM.

[Steve Zissou]

it definitly has an extremely potent effect on me. It gives me a similar feeling in my brain to when I am fasting. A kind of buzzing/tingleing feeling in my brain. It's a shame about the joint issues otherwise i would take a gram a day of this stuff.

[Mind]

I only have used it sparingly over the past few years. I never really "felt" any effect.