Cognitive functions of the brain decline with age. One of the protective cell types in the brain are called microglia cells. However, these microglia cells also loose function with age.
Our aim is to replace non-functional microglia with new and young microglia cells derived from adult stem cells.
We will inject these young microglia cells into 'Alzheimer mice'- a model for Alzheimers disease.
After giving the cells some time to work, we will sacrifice the mice and measure microglia activity, neurogenesis, proliferation of neuroprogenitors and plaque density in the brain.
A reduction in plaque density of Alzheimer mice would be a first proof that the transplanted microglia are performing their expected function.
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Scientific research is the only way to conquer the blight of involuntary death. The ImmInst.org community is not rich, so we pick our priorities quite carefully.
The Microglia Stem Cell was of interest for the following reasons:
- it investigates a crucial age related pathology in the brain
- it aims to develop a practical therapeutic solution in the not too distant future
- it is small enough that your donation, every cent of which will be matched by ImmInst, *will* make a real difference
- it is led by a reputable scientist who will respond to community questions and update us periodically on the progress of the research
Any donation, of any amount is appreciated. We need at least $16.000 to get going, with the matched funding in place that means at least $8000 from donors like you. Any surplus would go into the next scientific research initiative that is already in the pipeline.
How to Donate?
If you would like to donate to the ImmInst science funding drive, just follow these simple steps.
1.) http://www.imminst.org/forum/index.php?app=donate'>Go to the main donate page located here
2.) Next select or enter the amount you wish to donate, remember if you are entering an amount, follow the standard 2 decimal place system. http://www.imminst.org/forum/index.php?app=donate'> src="http://www.imminst.org/forum/public/style_images/donation_tracker/verified/paypal_verified_seal_60x60.gif" align="right" hspace=5 vspace=5>
Example: If you want to donate 15 dollars, then enter 15.00
3.) Now select the currency you wish to donate in, then click the donate button.
4.) You'll now see a new page, if you would like to remain anonymous, then check the appropriate box.
The automated payment system is set up to use PAYPAL. If you are unable to use paypal, your donation can also be made by via Google Checkout (scroll down on that page) . |
cheque
Please note:Every cent you donate will go directly to this cause. There are no admin costs or hidden charges - BUT we have to pay a fee for payment transfer services like paypal. Therefore, if you are thinking of making a larger donation ($400+), please consider sending it by cheque to
Imminst,
1022 Stark Street
Wausau, WI 54403, USA
Please include a note indicating your user/display name in the forums in the note section of the check, unless you wish to remain anonymous.
http://www.imminst.org/ScienceFunding