• Log in with Facebook Log in with Twitter Log In with Google      Sign In    
  • Create Account
  LongeCity
              Advocacy & Research for Unlimited Lifespans

Photo
* * * * - 2 votes

Resveratrol and Baileys


  • Please log in to reply
29 replies to this topic

#1 Young Paul

  • Guest
  • 55 posts
  • 12
  • Location:spain
  • NO

Posted 30 December 2010 - 03:16 PM


After experimenting with Resveratrol, I mixed it with vodka and used it sublingually and got a good buzz. Then I melted some white chocolate sprinkled in some REs and divided the cooled bar into pieces to be sucked when necesary. But now the best buzz ever for stimulation is mixing 500mg with Baileys, it sems to dissolve in the cream, then the alcohol seems to boost the under tongue absorption and the result is a speedy hyper concentration and alertness.
Posted Image
  • like x 4
  • Dangerous, Irresponsible x 1

#2 2tender

  • Guest
  • 669 posts
  • 34
  • Location:USA

Posted 30 December 2010 - 10:12 PM

Sounding Great!
  • Dangerous, Irresponsible x 1

sponsored ad

  • Advert
Click HERE to rent this advertising spot to support LongeCity (this will replace the google ad above).

#3 malbecman

  • Guest
  • 722 posts
  • 141
  • Location:Sunny CA

Posted 03 January 2011 - 05:37 PM

Irish-Res? :-D

#4 unglued

  • Guest
  • 171 posts
  • 36

Posted 15 January 2011 - 11:34 AM

In my experience, it takes ounces of 80-proof vodka or brandy to dissolve 125mg of pure resveratrol powder and become clear. Anything less, and the resveratrol remains suspended, making a milky-white fluid. Since Bailey's is already milky-white, I don't know how we could tell that the resveratrol is actually dissolved and not just suspended.

#5 maxwatt

  • Member, Moderator LeadNavigator
  • 4,911 posts
  • 1,587
  • Location:New York

Posted 15 January 2011 - 02:04 PM

In my experience, it takes ounces of 80-proof vodka or brandy to dissolve 125mg of pure resveratrol powder and become clear. Anything less, and the resveratrol remains suspended, making a milky-white fluid. Since Bailey's is already milky-white, I don't know how we could tell that the resveratrol is actually dissolved and not just suspended.

The milk proteins also bind to resveratrol, and act as a dispersant. I've no doubt that this method of delivery increases bioavailability. Dispersion alone is enough to increase bioavailability; SRT501 was a dispersion. Even if res is not fully dissolved, it is credible that some is being absorbed faster through the oral mucosa due to the alcohol.

#6 niner

  • Guest
  • 16,276 posts
  • 2,000
  • Location:Philadelphia

Posted 15 January 2011 - 03:22 PM

In my experience, it takes ounces of 80-proof vodka or brandy to dissolve 125mg of pure resveratrol powder and become clear. Anything less, and the resveratrol remains suspended, making a milky-white fluid. Since Bailey's is already milky-white, I don't know how we could tell that the resveratrol is actually dissolved and not just suspended.

The milk proteins also bind to resveratrol, and act as a dispersant. I've no doubt that this method of delivery increases bioavailability. Dispersion alone is enough to increase bioavailability; SRT501 was a dispersion. Even if res is not fully dissolved, it is credible that some is being absorbed faster through the oral mucosa due to the alcohol.

Dispersion is part of it, and micronization is part of it. Between the alcohol, the lipids, and the milk proteins, Baileys would seem to be hitting the trifecta. Plus it tastes good. My only problem with it is the interaction of resveratrol with our biological clock system causing morning to be the best time to use it, so that makes alcohol a little sketchy. Might be fun for an afternoon dose, though.

#7 hamishm00

  • Guest
  • 1,001 posts
  • 84
  • Location:United Arab Emirates

Posted 16 January 2011 - 05:09 AM

I follow up evening doses of res with melatonin, as you suggested, and perhaps counteracting that somewhat.

#8 Young Paul

  • Topic Starter
  • Guest
  • 55 posts
  • 12
  • Location:spain
  • NO

Posted 29 January 2011 - 11:39 PM

isn't it possible that somehow the alcohol improves buccal absorption? what I mean is that maybe the alcohol sort of opens the door a bit wider. Then what little RES has been disolved in the cream,lipids, and alcohol would have a better effect.... even opening up a capsule of RES and swishing around my mouth seems to work better, or is this just placebo?

Edited by Young Paul, 29 January 2011 - 11:43 PM.


#9 maxwatt

  • Member, Moderator LeadNavigator
  • 4,911 posts
  • 1,587
  • Location:New York

Posted 30 January 2011 - 05:37 AM

isn't it possible that somehow the alcohol improves buccal absorption? what I mean is that maybe the alcohol sort of opens the door a bit wider. Then what little RES has been disolved in the cream,lipids, and alcohol would have a better effect.... even opening up a capsule of RES and swishing around my mouth seems to work better, or is this just placebo?

I am sure it is not placebo. When taken in a capsule, I believe resveratrol tends to clump in an undissolved bolus that can pass trough you with little absorption. Swishing it around with liquid disperses it, so more is exposed to your intestinal walls and so more is likely to be absorbed. Alcohol can be absorbed sublingually, so that might be felt as an effect. Whether it aids int he transport of resveratol is possible, but questionable.

#10 niteinnyc

  • Guest
  • 57 posts
  • 6

Posted 01 February 2011 - 05:28 AM

What do you guys think about first mixing the res into a small amount of alcohol to dissolve it, and then adding that into a whey protein shake? It seems like this would provide both high dissolution and dispersion at the same time, and without having to consume much alcohol.

#11 Young Paul

  • Topic Starter
  • Guest
  • 55 posts
  • 12
  • Location:spain
  • NO

Posted 01 February 2011 - 07:03 PM

I don't know why anyone would swallow a capsule of Res, when it is almost tasteless. It's so simple to open up the capsule and swish the res around the mouth with or without Baileys. This way we get the benefit of buccal absorption, and slowing down liver-degradation, plus avoiding the problems that capsules have with stomach absorption. I also tried dissolving in white chocolate. Another way is to make a small bag using a coffee filter and leave it under the tongue.

#12 unglued

  • Guest
  • 171 posts
  • 36

Posted 05 February 2011 - 07:10 PM

I don't know why anyone would ever eat white chocolate, since it's almost tasteless.

But seriously: doesn't the heat from molten chocolate degrade the trans-resveratrol? I have tried mixing resveratrol plus brandy or Kahlua with cold chocolate soy milk, though, based on what I've seen on this topic and elsewhere in this forum.

Here's another technique I've tried: Mix several days' servings of resveratrol into a few ounces of vodka in a bottle, enough to saturate it and leave plenty of undissolved resveratrol at the bottom. Store in a cabinet, wrapped in foil to protect from UV. Every day, shake it thoroughly and pour a few drops into white wine (which I prefer to red). The cloud seems to disappear quickly, as though the extra alcohol is enough to dissolve the remaining particles. It's probably a much lower dose than a pill but much higher than unaltered red wine, and I can sip it over the course of half an hour.

#13 okok

  • Guest
  • 340 posts
  • 439

Posted 05 February 2011 - 07:57 PM

I think that t-res is quickly degraded (even upon the second opening a wine bottle) is a refuted myth supp manufacturers tried to purport (to sell their expensive NO sealed capsules). Seen a study with continuous distillation for hours with no noticeable loss.
Anyone have an update on the viability of dmso-solved res? How about liposomes? Quite easy to do on your own with an ultrasonic device.

#14 maxwatt

  • Member, Moderator LeadNavigator
  • 4,911 posts
  • 1,587
  • Location:New York

Posted 05 February 2011 - 09:04 PM

I don't know why anyone would ever eat white chocolate, since it's almost tasteless.

But seriously: doesn't the heat from molten chocolate degrade the trans-resveratrol? I have tried mixing resveratrol plus brandy or Kahlua with cold chocolate soy milk, though, based on what I've seen on this topic and elsewhere in this forum.

Here's another technique I've tried: Mix several days' servings of resveratrol into a few ounces of vodka in a bottle, enough to saturate it and leave plenty of undissolved resveratrol at the bottom. Store in a cabinet, wrapped in foil to protect from UV. Every day, shake it thoroughly and pour a few drops into white wine (which I prefer to red). The cloud seems to disappear quickly, as though the extra alcohol is enough to dissolve the remaining particles. It's probably a much lower dose than a pill but much higher than unaltered red wine, and I can sip it over the course of half an hour.


Chocolate cannot be heated over about 110 degrees F, or it is ruined. It has to be cooled quicly on acool stone surface to be tempered. Thee are about 6 crystalline forms it takes, and there is an art to getting the right one so it melts at body temperature, in your mouth, without being grainy. But resveratrol is stable at teh temperatures involved.

A study baking resveratrol in blueberry muffins at 350 Fahrenheit, found that resveratrol degraded at this temperature, but 60% remained unchanged. So there is some latitude in cooking it. I have made chocolates with resveratrol, about 8% by volume. I can't say it's any better absorbed than some of the other methods we use, but it tastes good.

#15 Young Paul

  • Topic Starter
  • Guest
  • 55 posts
  • 12
  • Location:spain
  • NO

Posted 06 February 2011 - 01:42 AM

Anyone know if Resveratrol would dissolve in coconut oil, because I think it's an excellent carrier for skin absorption, maybe it could make a great suntan lotion
and made into a patch for slow absorption.?

#16 niner

  • Guest
  • 16,276 posts
  • 2,000
  • Location:Philadelphia

Posted 06 February 2011 - 04:53 AM

Anyone know if Resveratrol would dissolve in coconut oil, because I think it's an excellent carrier for skin absorption, maybe it could make a great suntan lotion
and made into a patch for slow absorption.?

I don't know the exact solubility of resveratrol in coconut oil, but based on my attempt to dissolve it in olive oil, I'd say that it's probably not very high. Resveratrol would prefer a solvent that was a bit more polar, like ethanol. Given its two aromatic groups, a solvent that had aromatic character, along with a polar component would be good, if you could find one that was nontoxic. More importantly though, is the issue of transdermal absorption. The ability of resveratrol to cross the skin barrier was measured by a Chinese group using a variety of solvent systems. The best system they found had such a low transmission flux that transdermal dosing appears to be unable to provide anywhere near the dose you would need systemically. It might have some value as a skin treatment, though. For systemic use, I would stick with oral or buccal dosing for resveratrol.

#17 Young Paul

  • Topic Starter
  • Guest
  • 55 posts
  • 12
  • Location:spain
  • NO

Posted 07 February 2011 - 11:52 AM

I believe that it's very easy to dissolve resveratrol in coconut oil, see:
solubility of resvaratrol in coconut

and I'm told that coconut oil easily penetrates the skin. But my question is, would the dissolved RES also pass through.
I belive that RES has a saturation level, and a slower more consistent rate would be better than a fast spike for longevity, although the stimulating buzz of resveratrol + alcohol swished around the mouth is exceadingly pleasurable.

Another idea I have is to dissolve the Res in coconut oil,with a splash of rum, then mix with melted chocolate and finely chopped raisons, and place in the freezer, to make tiny suckable candies that would melt under the tongue.

#18 maxwatt

  • Member, Moderator LeadNavigator
  • 4,911 posts
  • 1,587
  • Location:New York

Posted 07 February 2011 - 12:09 PM

I believe that it's very easy to dissolve resveratrol in coconut oil, see:
solubility of resvaratrol in coconut

and I'm told that coconut oil easily penetrates the skin. But my question is, would the dissolved RES also pass through.
I belive that RES has a saturation level, and a slower more consistent rate would be better than a fast spike for longevity, although the stimulating buzz of resveratrol + alcohol swished around the mouth is exceadingly pleasurable.

Another idea I have is to dissolve the Res in coconut oil,with a splash of rum, then mix with melted chocolate and finely chopped raisons, and place in the freezer, to make tiny suckable candies that would melt under the tongue.


You don't need the coconut oil, though it would act as an extender so you'd need less chocolate, if it didn't interfere with chocolates hardening properties on cooling. I know from experience that resveratrol dissolves quite well in melted chocolate. If you buy tempered chocolate, and carefully melt in a double-boiler so as not to exceed about 110 Fahrenheit, which would ruin the chocolate, you can mix in about 10% resveratrol by weight and pour into a suitable mold, or over frozen bananas, or nuts and raisins.

#19 Young Paul

  • Topic Starter
  • Guest
  • 55 posts
  • 12
  • Location:spain
  • NO

Posted 07 February 2011 - 12:45 PM

What about my new recipe. (Irish Res Coffee)

1. Dissolve resveratrol in rum, Baileys, or whisky,
2. Add to coffee with cream, and sip slowly while letting the flavours excite your sublingual absorbers.
3. For an extra buzz, you could also dissolve some resveratrol in some melted chocolate, then place in the freezer, then sprinkle some choc chips onto the creamy coffee.

For those who don't take coffee could be done with healthy Chicory, and this way one could drink the stuff all day long.

#20 niner

  • Guest
  • 16,276 posts
  • 2,000
  • Location:Philadelphia

Posted 08 February 2011 - 12:34 AM

I believe that it's very easy to dissolve resveratrol in coconut oil, see:
solubility of resvaratrol in coconut

and I'm told that coconut oil easily penetrates the skin. But my question is, would the dissolved RES also pass through.

In that paper, they were using an emulsion where coconut oil was one of many components. That's a different situation than resveratrol going into solution in coconut oil. Even if it did dissolve, (and I still think that's a big if, though I haven't run the experiment) the penetration of resveratrol into systemic circulation would be low, based on the published report.

#21 2tender

  • Guest
  • 669 posts
  • 34
  • Location:USA

Posted 08 February 2011 - 04:08 PM

While it wouldnt be viable for systemic absorbtion, it would be enough to absorb into epidermis. There is a carrier available that would help with systemic absobtion, but its an involved process to mix. Other topical Resveratrol products are available as well as some facial skin products that contain Resveratrol. Oral use on a regular basis, alone, should help with skin add some tocotrienols and RLA ie mito-gold for synergy. JMO

#22 maxwatt

  • Member, Moderator LeadNavigator
  • 4,911 posts
  • 1,587
  • Location:New York

Posted 08 February 2011 - 05:27 PM

Emu oil is said to be one such carrier, by sites selling emu oil.

#23 sagecucumber

  • Guest
  • 32 posts
  • -1

Posted 28 March 2011 - 06:00 PM

Paul Young = aspiring resveratrol pastry chef

#24 unglued

  • Guest
  • 171 posts
  • 36

Posted 08 May 2011 - 08:44 PM

What about my new recipe. (Irish Res Coffee)

1. Dissolve resveratrol in rum, Baileys, or whisky,
2. Add to coffee with cream, and sip slowly while letting the flavours excite your sublingual absorbers.
3. For an extra buzz, you could also dissolve some resveratrol in some melted chocolate
...


Is it known by now whether trans-resveratrol degrades at high temperatures or not?

#25 maxwatt

  • Member, Moderator LeadNavigator
  • 4,911 posts
  • 1,587
  • Location:New York

Posted 09 May 2011 - 12:40 AM

There was a paper describing baking Blueberry Resveratrol muffins for 30 minutes at 300 degrees for 30 minutes. 70 % of the Resveratrol was not degraded.

Edited by maxwatt, 09 May 2011 - 03:18 AM.


#26 bosozok

  • Guest
  • 25 posts
  • 1

Posted 09 May 2011 - 02:55 AM

There was a paper describing baking Blueberry Resveratrol muffins for 30 minutes at 300 degrees for 30 minutes. 70 % of the Resveratrol was not degraded.

I think ya' all should get together and publish the ImmInst.org Long Life Cookery Book. :-D

Edited by maxwatt, 09 May 2011 - 03:18 AM.


#27 Young Paul

  • Topic Starter
  • Guest
  • 55 posts
  • 12
  • Location:spain
  • NO

Posted 18 January 2018 - 02:00 PM

I just read an abstract that says that resveratrol binds to milk proteins making it hard to absorb ... any truth in that?
Anyone know what top temperature will degrade resveratrol (I want to dissolve it in coffee with milk or cacao? I think that luke warm should be ok.


  • Needs references x 1

#28 Oakman

  • Member
  • 520 posts
  • 259
  • Location:CO

Posted 18 January 2018 - 04:17 PM

I've done a bit of experimenting along these lines. For instance, R dissolves nicely in Everclear (90%). But if you begin adding water back in, then the R begins to come out of solution as the ethanol content decreases. Unfortunately, Everclear is not drinkable by itself, so mixing with something is essential. So for inspiration, I combined suggestions here (below) given when taking their micronized R, with other info I have read.

 

"Estimated to be up to *220% or more effective than regular resveratrol when taken dry. Estimated to be up to *300% or more effective when mixed into a liquid, tonic or emulsifier! Typical liquids and emulsifiers for tonics include: Lecithins, palm oils, rapeseed oils, soy bean oils, sunflower oils. Some folks use chocolate, HPMC, and chemists use tween 80 which tastes pretty bad but has good results.

 

We also recommend mixing the micronized powder in a whey protein isolate shake, as it binds to the Beta-lactoglobulin protein in whey and this increases it's solubility. You can add your own fruits, powder supplements or veggies to make your ultimate dietary supplement drink."

 

So my 'solution' for their R is to mix, 1) 250mg R with 2.5 grams R-Ribose, 2) 10 grams whey protein concentrate, 3) a few mL of liquid soy lecithin, 4) a tsp of "Brain Octane Oil (C8 MCTs), 5) in 1/3 cup OJ. Then power blend for a bit and finally stir in 1 tsp Liposomal R+C for a nice tonic. I use this as part of my 48hr R+C 'overdose' protocol.

 

I suppose I should use the whey isolate, but... (link to R+milk protein study) There are many out there, but this has no paywall.


Edited by Oakman, 18 January 2018 - 04:18 PM.

  • like x 1

#29 to age or not to age

  • Guest
  • 144 posts
  • 86
  • Location:NY

Posted 18 January 2018 - 04:59 PM

We have been mixing it with Bailey's for years. Just let it dissolve in its own time, then wisk it.


Edited by to age or not to age, 18 January 2018 - 05:00 PM.

  • like x 1

sponsored ad

  • Advert
Click HERE to rent this advertising spot to support LongeCity (this will replace the google ad above).

#30 Nate-2004

  • Member
  • 1,989 posts
  • 239
  • Location:Philadelphia
  • NO

Posted 19 January 2018 - 07:33 PM

 

In my experience, it takes ounces of 80-proof vodka or brandy to dissolve 125mg of pure resveratrol powder and become clear. Anything less, and the resveratrol remains suspended, making a milky-white fluid. Since Bailey's is already milky-white, I don't know how we could tell that the resveratrol is actually dissolved and not just suspended.

The milk proteins also bind to resveratrol, and act as a dispersant. I've no doubt that this method of delivery increases bioavailability. Dispersion alone is enough to increase bioavailability; SRT501 was a dispersion. Even if res is not fully dissolved, it is credible that some is being absorbed faster through the oral mucosa due to the alcohol.

 

 

The reported solubility of R in ethanol is ~50mg/ml. You can get up to 600mg to dissolve in 12ml of ethanol. Try everclear 180 proof, dissolve it into 40ml then add 30ml of cream. Take 2 ml per hour for the day. Don't do this every day. Oakman's post has a similarly good recommendation.

 

Option 2: Add 20ml more ethanol and 1200mg quercetin and 500mg curcumin with piperine to the mix. Do 4 ml per hour in this case. Also drink coffee during the first part of the day and chamomile tea during the latter half of the day. See references in the other threads on this. The chamazulene, caffeine, curcumin and quercetin will help bioavailability by competing with relevant enzymes. Also, try adding a big parsley and celery smoothie, mix in whatever fruits you want to make it taste good. Lots of parsley, like 100g or more.


Edited by Nate-2004, 19 January 2018 - 07:38 PM.

  • Informative x 1
  • like x 1




0 user(s) are reading this topic

0 members, 0 guests, 0 anonymous users